Thesaurus for histopathological findings in publically available reports of repeated-dose oral toxicity studies in rats for 156 chemicals

Abstract

INTRODUCTIONStandardization of nomenclature and the construction of a thesaurus for histopathological findings are important for the proper comparative evaluation of the histopathological data from different repeated-dose toxicity studies (RTS). There are a number of endpoints for hazard identification in RTS such as body weight change, organ weights, and hematological and blood biochemical examinations. Among them, histopathological findings can be unique indicators because a number of findings are qualitatively diagnosed by toxicologic pathologists, and these qualitative assessments are often conclusive or sensitive indicators of toxicities induced by chemicals. However, the descriptive terminology for histopathological findings, especially non-neoplastic lesions, has not yet been stand- ABSTRACT -Because histopathological findings are often conclusive indicators of the toxicities of chemicals, standardization of nomenclature and construction of a thesaurus for histopathological findings are important for the comparative evaluation of histopathological data from repeated-dose toxicity studies (RTS). However, terms for histopathological findings have not been standardized and different technical terms are used to indicate almost the same thing in RTS. The present study was conducted to construct an easy-to-use thesaurus for histopathological findings in order to facilitate hazard assessments of untested chemicals by the category approach using knowledge of the toxicity of analogue chemicals. We used reports of 28-day RTS, conducted on rats by gavage, which were posted on the websites of the National Institute of Health Sciences (NIHS) and the National Institute of Technology and Evaluation (NITE). The histopathological data were from 156 reports on RTS conducted by 13 institutions in Japan. As a result of this study, major parts of the thesaurus were devoted to the findings in the liver, kidney, stomach, adrenal, thyroid and testis; the first three organs are known to be the main targets of chemicals. We also decided that findings such as swelling and enlargement of hepatocytes should be categorized as synonyms for terms meaning hypertrophy. Our thesaurus will be helpful in assessing or screening new untested chemicals by the category approach using knowledge of the toxicities of analogues of the new chemical. The RTS database with this thesaurus will be made publically available in 2012.

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