Theta and alpha oscillations in human hippocampus and medial parietal cortex support the formation of location‐based representations

Abstract

Our ability to navigate in a new environment depends on learning new locations. Mental representations of locations are quickly accessible during navigation and allow us to know where we are regardless of our current viewpoint. Recent functional magnetic resonance imaging (fMRI) research using pattern classification has shown that these location‐based representations emerge in the retrosplenial cortex and parahippocampal gyrus, regions theorized to be critically involved in spatial navigation. However, little is currently known about the oscillatory dynamics that support the formation of location‐based representations. We used magnetoencephalogram (MEG) recordings to investigate region‐specific oscillatory activity in a task where participants could form location‐based representations. Participants viewed videos showing that two perceptually distinct scenes (180° apart) belonged to the same location. This “overlap” video allowed participants to bind the two distinct scenes together into a more coherent location‐based representation. Participants also viewed control “non‐overlap” videos where two distinct scenes from two different locations were shown, where no location‐based representation could be formed. In a post‐video behavioral task, participants successfully matched the two viewpoints shown in the overlap videos, but not the non‐overlap videos, indicating they successfully learned the locations in the overlap condition. Comparing oscillatory activity between the overlap and non‐overlap videos, we found greater theta and alpha/beta power during the overlap relative to non‐overlap videos, specifically at time‐points when we expected scene integration to occur. These oscillations localized to regions in the medial parietal cortex (precuneus and retrosplenial cortex) and the medial temporal lobe, including the hippocampus. Therefore, we find that theta and alpha/beta oscillations in the hippocampus and medial parietal cortex are likely involved in the formation of location‐based representations.

Multimodal MEG and microstructure-MRI investigations of the human hippocampal scene network

“…It should be noted that an increase in theta power, in conjunction with spatial processing behaviours, has also been reported (e.g., Backus et al, 2016;Osipova et al, 2006;Pu et al, 2017). Recently, Satish et al, (2024) found that hippocampal and posteromedial cortical theta was enhanced when participants watched videos showing that previously viewed scenes were from the same location (rather than two different locations). They concluded that such theta power increases supported the formation of 'location-based representations'.…”