Theta-band phase locking during encoding leads to coordinated entorhinal-hippocampal replay

Santos-Pata, Diogo; Barry, Caswell; Ólafsdóttir, H. Freyja

doi:10.1016/j.cub.2023.09.011

Cited by 4 publications

(3 citation statements)

References 48 publications

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“…The foregoing results corroborate the critical role of MEC L5a neurons receiving V2 projections during navigation. However, since MEC L5a also receives inputs from other brain areas, the above observations may be attributed to alternative mechanisms, such as learning-related increase in coordination between the deep MEC and the hippocampus 45 . Thus, we would like to investigate features of V2→MEC L5a projections during navigation tasks directly.…”

Section: Resultsmentioning

confidence: 99%

A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation

Shao,

Chen,

et al. 2024

Nat Commun

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Visual information is important for accurate spatial coding and memory-guided navigation. As a crucial area for spatial cognition, the medial entorhinal cortex (MEC) harbors diverse spatially tuned cells and functions as the major gateway relaying sensory inputs to the hippocampus containing place cells. However, how visual information enters the MEC has not been fully understood. Here, we identify a pathway originating in the secondary visual cortex (V2) and directly targeting MEC layer 5a (L5a). L5a neurons served as a network hub for visual processing in the MEC by routing visual inputs from multiple V2 areas to other local neurons and hippocampal CA1. Interrupting this pathway severely impaired visual stimulus-evoked neural activity in the MEC and performance of mice in navigation tasks. These observations reveal a visual cortical-entorhinal pathway highlighting the role of MEC L5a in sensory information transmission, a function typically attributed to MEC superficial layers before.

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Section: Resultsmentioning

confidence: 99%

A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation

Shao,

Chen,

et al. 2024

Nat Commun

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“…Theta-phase locking contrasts with other theta phase-dependent phenomena such as theta-phase precession where single neurons activate at successively earlier theta phases over time ( 13 , 37 – 41 ). In rodents, theta-phase locking has been described in a variety of neurons including spatially-modulated neurons representing locations and directions ( 31 , 37 , 42 – 45 ). Due to its high prevalence both within and across brain regions, theta-phase locking has been suggested to organize the activity of single neurons into neuronal assemblies ( 22 , 30 , 36 ), to enable interregional communication between neurons ( 32 , 33 , 36 , 46 ), and to trigger which neurons become linked during encoding to participate in the same replay events during consolidation ( 42 ).…”

Section: Introductionmentioning

confidence: 99%

“…In rodents, theta-phase locking has been described in a variety of neurons including spatially-modulated neurons representing locations and directions ( 31 , 37 , 42 – 45 ). Due to its high prevalence both within and across brain regions, theta-phase locking has been suggested to organize the activity of single neurons into neuronal assemblies ( 22 , 30 , 36 ), to enable interregional communication between neurons ( 32 , 33 , 36 , 46 ), and to trigger which neurons become linked during encoding to participate in the same replay events during consolidation ( 42 ). Phase locking of neuronal assemblies at distinct theta phases may furthermore help separate different mnemonic processes such as encoding and retrieval ( 45 , 47 , 48 ).…”

Section: Introductionmentioning

confidence: 99%

Theta-phase locking of single neurons during human spatial memory

Guth,

Brandt,

Reinacher

et al. 2024

Preprint

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The precise timing of single-neuron activity in relation to local field potentials may support various cognitive functions. Extensive research in rodents, along with some evidence in humans, suggests that single-neuron activity at specific phases of theta oscillations plays a crucial role in memory processes. Our fundamental understanding of such theta-phase locking in humans and its dependency on basic electrophysiological properties of the local field potential is still limited, however. Here, using single-neuron recordings in epilepsy patients performing a spatial memory task, we thus aimed at improving our understanding of factors modulating theta-phase locking in the human brain. Combining a generalized-phase approach for frequency-adaptive theta-phase estimation with time-resolved spectral parameterization, our results show that theta-phase locking is a strong and prevalent phenomenon across human medial temporal lobe regions, both during spatial memory encoding and retrieval. Neuronal theta-phase locking increased during periods of elevated theta power, when clear theta oscillations were present, and when aperiodic activity exhibited steeper slopes. Theta-phase locking was similarly strong during successful and unsuccessful memory, and most neurons activated at similar theta phases between encoding and retrieval. Some neurons changed their preferred theta phases between encoding and retrieval, in line with the idea that different memory processes are separated within the theta cycle. Together, these results help disentangle how different properties of local field potentials and memory states influence theta-phase locking of human single neurons. This contributes to a better understanding of how interactions between single neurons and local field potentials may support human spatial memory.

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Memory consolidation: Building influence over the entorhinal cortex

Nolan

2023

Current Biology

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Theta-band phase locking during encoding leads to coordinated entorhinal-hippocampal replay

Cited by 4 publications

References 48 publications

A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation

A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation

Theta-phase locking of single neurons during human spatial memory

Memory consolidation: Building influence over the entorhinal cortex

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