Thêta-Cream® versus Bepanthol® Lotion in Breast Cancer Patients under Radiotherapy

Abstract

In direct comparison with dexpanthenol-containing lotion, no advantage for Thêta-Cream was found. Higher costs and problems with skin marks prevent a general recommendation.

RTOG criteria to evaluate acute skin reaction and its risk factors in patients with breast cancer submitted to radiotherapy

“…When the breast region and the degree of skin reaction are evaluated, 100% of degree 3 reactions were in the inframammary region. Such results are found in several studies, which show the predominance of degree 3 reactions in this region because of the constant friction and higher humidity in this area (3,10) .…”

“…The influence of tamoxifen on the incidence of pulmonary fibrosis has been showed, but its effect on skin has not been reported (10) .…”

“…There are several models of breast measure to relate with skin reaction. The bra size, maximum breast diameter (10) and volume in centimeters 3 were considered (14) . The breast curve any healing process (6) .…”

Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

“…Skin reactions were often assessed by one evaluator, which was commonly a radiation oncologist, dermatologist, research nurse, research assistant, radiation therapist, principal investigator, or other medical professional 3,17,20,21,24,26,27,32,33,35,39,44,46,50 . A few studies incorporated an inter-rater reliability measure by having more than one evaluator assess the skin reactions 23,34,36,45,49,51 ; the remaining studies did not describe who assessed the radiated area or areas 2,16,19,25,28,30,31,38,[41][42][43]47,48 .…”

“…Röper et al 34 alternatively assigned patients to use Thêta-Cream (TheraCosm, Dellstedt, Germany) or Bepanthol lotion (Bayer Schering Pharma, Wilmington, DE, U.S.A.) and reported no significant differences between the groups.…”