Theta–gamma coupling and ordering information: a stable brain–behavior relationship across cognitive tasks and clinical conditions

Abstract

3,5 and on behalf of the PACt-MD Study Group Ordering of information is a critical component that underlies several cognitive functions. Prefrontal theta-gamma coupling (TGC) is a neurophysiologic measure associated with ordering of information during the performance of a working memory task (N-back).Little is known about the relationship between TGC and ordering during other cognitive tasks or whether the relationship between TGC and ordering of information is independent of clinical condition. This study aimed to determine whether the relationship between TGC and ordering of information exists independent of a task and its timing, and whether this relationship is the same in different clinical conditions. A total of 311 participants were assessed using a neuropsychological battery that included the N-back during which TGC was measured; two other tasks that also require ordering; and three tests that do not require ordering. All non-Nback tasks were completed several days separate from the N-back by a mean interval (SD) of 5.14 (8.03). Our three hypotheses were that TGC during the N-back task would be associated with performance on N-Back and other cognitive tasks that also require ordering, but not with performance on cognitive tasks that do not require ordering; and that these relationships will be independent of clinical diagnosis. Multivariate linear regression results show that TGC was associated with performance on the ordering tasks but not the non-ordering tasks. In addition, there was no interaction between TGC and diagnosis. Our study is the first to demonstrate that TGC is a neurophysiologic measure of ordering information across several cognitive tasks that require ordering, and this TGC-ordering relationship is stable over time even when several days separate the measurement of TGC and the performance of the ordering tasks. Our results also show that this relationship is independent of clinical diagnosis, supporting the brain-behavior nature of this relationship. These results highlight the importance of TGC in ordering-based cognition, and suggest that TGC could be a valid target for interventions that aim to enhance this function across cognitive tasks and clinical conditions.

Backpropagation-Based Recollection of Memories: Biological Plausibility and Computational Efficiency

“…5 where we reconstruct an image in a backward-propagation fashion from a small set of neural activations. Finally, theta oscillations and theta-gamma coupling in particular are believed to additionally (ii) structure memory retrieval of events in the correct order [156, 155, 162], an aspect that we leave for future work (cf. discussion).…”

Theta-gamma phase-amplitude coupling: physiological basics, analysis methods, and perspectives of translation into clinical practice

“…в лонгитюдном исследовании продемонстрирована стабильность выявляемой ассоциации между РП и ТГС у здоровых пожилого возраста и пациентов с рекуррентной депрессией без когнитивного дефицита [70]. Примечательно, что по данным более раннего исследования этой группы ТГС ассоциировано только с выполнением когнитивных тестов, требующих упорядочения информации, и не зависит от диагноза (исследовались пациенты с рекуррентной депрессией, умеренными когнитивными расстройствами и здоровые добровольцы) [39]. Таким образом, взаимосвязь между ТГС и упорядочением информации не зависит не только от конкретной задачи, но и от клинического состояния и, вероятно, отражает специфическую нейрофизиологическую основу указанных процессов [1].…”

“…В соответствии с результатами экспериментов была сформулирована гипотеза нейронного «тета-гамма-кода», согласно которой при передаче сложных сигналов, содержащих несколько объектов, взаимодействие между отдельными популяциями нейронов обеспечивается сопряжением их тета-ритмов, в то время как гамма-осцилляции определяют отдельные объекты в структуре передаваемого сообщения [4]. Предполагается, что ТГС отражает процесс упорядочения воспринимаемой информации во времени: отдельные гамма-циклы соответствуют восприятию единиц информации, а тета/альфа-активность обеспечивает субстрат для кодирования временнóго интервала репрезентации этих единиц [37][38][39][40][41][42][43]. F. Roux и соавт.…”

Event-Related Phase-Amplitude Coupling During Working Memory of Musical Chords

“…The couplings of theta-alpha [24], [36], delta-beta [14], [16], [37], deltagamma [5], [19], [34], [44], alpha-beta [18], [34], and alpha-gamma [14], [20], [28], [32], [46] have been proposed in previous studies involving memory tasks. Additionally, in the past few years, PAC has also been associated with clinical conditions and diseases related to cognitive impairment [49]- [55].…”