Theta-Gamma Coupling and Working Memory in Alzheimer’s Dementia and Mild Cognitive Impairment

Goodman, Michelle; Kumar, Sanjeev; Zomorrodi, Reza; Ghazala, Zaid; Cheam, Amay; Barr, Mera S.; Daskalakis, Zafiris J.; Blumberger, Daniel M.; Fischer, Corinne E.; Flint, Alastair J.; Mah, Linda; Herrmann, Nathan; Bowie, Christopher R.; Mulsant, Benoit H.; Rajji, Tarek K.

doi:10.3389/fnagi.2018.00101

Cited by 131 publications

(134 citation statements)

References 52 publications

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“…Herein we examine the effect of VFX on this endpoint. In addition, since increased gamma power has been linked to enhanced working memory (Alekseichuk et al, 2016;Goodman et al, 2018;Martorell et al, 2019, Iaccarino et al, 2016, we also examine the effect of CORT and VFX on spontaneous alternations in the T maze, which has been shown to measure spatial working memory in mice (Shoji et al, 2012).…”

Section: Increased Anxiety and Reduced Working Memory In Cort-treatedmentioning

confidence: 99%

Venlafaxine stimulates an MMP-9-dependent increase in excitatory/inhibitory balance in a stress model of depression

Alaiyed

McCann

Mahajan

et al. 2019

Preprint

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AbstractEmerging evidence suggests that there is a reduction in overall cortical excitatory to inhibitory balance in major depressive disorder (MDD), which afflicts approximately 14-20% of individuals. Reduced pyramidal cell arborization occurs with stress and MDD, and may diminish excitatory neurotransmission. Enhanced deposition of perineuronal net (PNN) components also occurs with stress. Since parvalbumin-expressing interneurons are the predominant cell population that is enveloped by PNNs, which enhance their ability to release GABA, excess PNN deposition likely increases pyramidal cell inhibition. In the present study we investigate the potential for matrix metalloprotease-9 (MMP-9), an endopeptidase secreted in response to neuronal activity, to contribute to the antidepressant efficacy of venlafaxine, a serotonin/norepinephrine reuptake inhibitor. Chronic venlafaxine increases MMP-9 levels in murine cortex, and increases both pyramidal cell arborization and PSD-95 expression in the cortex of wild-type but not MMP-9 null mice. We have previously shown that venlafaxine reduces PNN deposition and increases the power of ex vivo gamma oscillations in conventionally-housed mice. Gamma power is increased with pyramidal cell disinhibition and with remission from MDD. Herein we observe that PNN expression is increased in a corticosterone-induced stress model of disease and reduced by venlafaxine. As compared to mice that receive concurrent venlafaxine, corticosterone treated mice also display reduced ex vivo gamma power and impaired working memory. Autopsy-derived prefrontal cortex samples show elevated MMP-9 levels in anti-depressant treated MDD patients as compared to controls. These preclinical and postmortem findings highlight a link between extracellular matrix regulation and MDD.

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Section: Increased Anxiety and Reduced Working Memory In Cort-treatedmentioning

confidence: 99%

Venlafaxine stimulates an MMP-9-dependent increase in excitatory/inhibitory balance in a stress model of depression

Alaiyed

McCann

Mahajan

et al. 2019

Preprint

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“…Indeed, several human EEG studies have demonstrated a correlation between the modulation of gamma amplitude by theta phase in the frontal cortices and working memory processes (Canolty and Knight, 2010;Lisman and Jensen, 2013;Rajji et al, 2017). Weakening in this cross-frequency interaction has been correlated with the severity of cognitive impairment and dementia in patients (Goodman et al, 2018). Here we found that the phase-amplitude modulation between theta (4-8Hz) and low gamma (30-60Hz) from different recording sites in the dlPFC increased during the session (Figure 7).…”

Section: Discussionmentioning

confidence: 99%

Macaque anterior cingulate cortex deactivation impairs performance and alters lateral prefrontal oscillatory activities in a rule-switching task

Chan²,

Johnston³

et al. 2018

Preprint

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In primates, both the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (dlPFC) are key regions of the frontoparietal cognitive control network. To study the role of the dACC and its communication with the dlPFC in cognitive control, we recorded the local field potentials from the dlPFC before and during the reversible deactivation of the dACC, in macaque monkeys engaging in uncued switches between two stimulus-response rules. Cryogenic dACC deactivation impaired response accuracy during rule-maintenance, but not rule-switching, which coincided with a reduction in the correct-error difference in dlPFC beta activities specifically during maintenance of the more challenging rule. During both rule switching and maintenance, dACC deactivation prolonged the animals' reaction time and reduced task-related theta/alpha activities in the dlPFC; it also weakened dlPFC theta-gamma 2 phase-amplitude modulation. Thus, the dACC and its interaction with the dlPFC plays a critical role in the maintenance of a new, challenging rule. been implicated in attention and cognitive control (Tsujimoto et al., 2006;Tsujimoto et al., 2010;Voloh et al., 2015;Voloh and Womelsdorf, 2017;Womelsdorf et al., 2010). While less studied than theta, prefrontal beta oscillations (13-30Hz) has been suggested to orchestrate cell assemblies that maintain information in short-term memory (Kopell et al., 2011), predict reaction time (Buschman et al., 2012Ma et al., 2018), and reflect action outcome (Skoblenick et al., 2016). In between the theta and the beta bands, the alpha rhythms (9-12Hz) may help inhibit attention to irrelevant information (Buschman et al., 2012;Puig and Miller, 2015).Here, we found that cryogenic dACC deactivation impaired the animals' task performance in a manner consistent with an impairment of rule-maintenance, but not ruleswitching. This was manifested by a lower plateau in response accuracy rather than a delay in the implementation of the new rule. Correlated with this performance impairment was a reduction in the absolute difference in dlPFC fixation-period beta activities between correct and error trials, particularly for antisaccades. We also observed increased saccadic reaction time with both rules and across post-switch stages, which coincided with a reduction in task-related theta/alpha activities (5-15Hz) found for both rules in the dlPFC. Lastly, while theta-gamma phaseamplitude modulation in the dlPFC became stronger in the second halves of the sessions, during both on-and off-task periods, dACC deactivation reversed this pattern and resulted in a decrease in this cross-frequency interaction. Together our findings suggest a critical role of the dACC and its interaction with the dlPFC in the maintenance of new rules in a feedback-based rule-switching task. RESULTS dACC Deactivation Impaired Behavioral Performance on the Rule-Switch Task

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“…Thus, in humans with AD, an enhanced CFC between the gamma and low-frequency bands (in particular, theta) compared to healthy control was revealed [141]. During performance of working memory tasks, evidence for a relationship between altered theta-gamma coupling and working memory deficits in individuals with AD was obtained [143].…”

Section: A L T E R a T I O N S I N T H E T A -G A M M A C O H E R E Nmentioning

confidence: 95%

Changes in Theta and Gamma Network Oscillations during the Development of Neurodegenerative Disorders (Review)

Kichigina¹

2019

Sovrem Tehnol Med

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Theta and gamma oscillations registered in the hippocampus and neocortex are necessary for cognitive processes in the brain; their alterations are revealed in many neurological and psychiatric diseases. The most common forms of neurodegenerative disorders, Alzheimer's disease (AD) and temporal lobe epilepsy (TLE) are characterized by the loss of cells and progressive violations of cognitive functions, such as memory. Early diagnosis of diseases is very important for their successful treatment. Many efforts have been done for defining early signs of these diseases. Significant advances have been made in the searching of some AD and TLE reliable biomarkers with using biochemical and imaging approaches. However, there is a great need for the biomarkers that would reflect changes of brain activity within few milliseconds to obtain information about cognitive disturbances. In the present review, the data of recent literature specifying that the coherent analysis of the theta and gamma oscillations can be used in early diagnostics of TLE and AD are considered. These data show that in a brain with the developing neurodegenerative disorder the specific violations of the theta and gamma interaction are observed. We summarize here the data on the alterations of the theta and gamma coherence based on examples from TLE and AD and from models of these diseases. The specific disturbances in interactions of theta-gamma oscillations in hippocampal, hippocampal-entorhinal, hippocampal-prefrontal, and hippocampal-septal networks were revealed in the epileptic brain. In the AD models, marked changes were observed in the theta-gamma coupling in the subiculum, an output region of the hippocampus. In addition, a decreased theta-gamma interaction between the hippocampus and the parietal cortex as well as between the hippocampus and the prefrontal cortex was also shown.

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Theta-Gamma Coupling and Working Memory in Alzheimer’s Dementia and Mild Cognitive Impairment

Cited by 131 publications

References 52 publications

Venlafaxine stimulates an MMP-9-dependent increase in excitatory/inhibitory balance in a stress model of depression

Venlafaxine stimulates an MMP-9-dependent increase in excitatory/inhibitory balance in a stress model of depression

Macaque anterior cingulate cortex deactivation impairs performance and alters lateral prefrontal oscillatory activities in a rule-switching task

Changes in Theta and Gamma Network Oscillations during the Development of Neurodegenerative Disorders (Review)

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