Theta Oscillations Organize Spiking Activity in Higher-Order Visual Thalamus during Sustained Attention

Yu, Chunxiu; Stitt, Iain; Li, Yuhui; Zhou, Zhe; Sellers, Kristin K.; Fröhlich, Flavio

doi:10.1101/219626

Cited by 4 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One strategy forward is the development of animal models that have a broader shared substrate of structural and functional network connectivity with humans. For example, one of the authors (FF) has adapted the application of many of the cutting-edge systems neuroscience techniques such as optogenetic perturbations, 6 functional magnetic resonance imaging (fMRI), 7 and touch screen–based cognitive assays 8 to the ferret ( Mustela putorius furo ). The ferret is a domesticated carnivore with a gyrencephalic brain, with a well-defined prefrontal cortex (resembling the dorsolateral prefrontal cortex in primates 9 ) that is missing in mice.…”

Section: Target Identificationmentioning

confidence: 99%

Rational design of transcranial alternating current stimulation

Kurmann

Gast

Schindler

et al. 2018

Clinical and Translational Neuroscience

View full text Add to dashboard Cite

Network oscillations in the brain are routinely recorded in the clinic and in the research lab. Here we outline a new paradigm in which network oscillations serve as treatment targets for noninvasive brain stimulation. We show how transcranial alternating current stimulation (tACS) can be used to modulate network oscillations that are impaired in disorders of the central nervous system (CNS). Using rational design, a structured process of target identification, target engagement, and target validation can be deployed to develop effective noninvasive brain stimulation paradigms for the treatment of neurological and psychiatric illnesses. We conclude by outlining how this approach could be applied to two disorders of the CNS, depression and epilepsy, for which there already exist clinical brain stimulation treatment options.

show abstract

Section: Target Identificationmentioning

confidence: 99%

Rational design of transcranial alternating current stimulation

Kurmann

Gast

Schindler

et al. 2018

Clinical and Translational Neuroscience

View full text Add to dashboard Cite

show abstract

Functional dissociation of theta oscillations in the frontal and visual cortices and their long-range network during sustained attention

Han

Lee

Choi

2019

Preprint

View full text Add to dashboard Cite

1Theta-band (4-12 Hz) activities in the frontal cortex have been thought to be a key mechanism of 2 sustained attention and goal-related behaviors, forming a phase-coherent network with task-related 3 sensory cortices for integrated neuronal ensembles. However, recent visual task studies found that 4 selective attention attenuates stimulus-related theta power in the visual cortex, suggesting a 5 functional dissociation of cortical theta oscillations. To investigate this contradictory behavior of 6 cortical theta, a visual Go/No-Go task was performed with electroencephalogram recording in mice. 7 During the No-Go period, transient theta oscillations were observed in both the frontal and visual 8 cortices, but theta oscillations of the two areas were prominent in different trial epochs. By 9 separating trial epochs based on subjects' short-term performance, we found that frontal theta was 10 prominent in good-performance epochs, while visual theta was prominent in bad-performance 11 epochs, exhibiting a functional dissociation of cortical theta rhythms. Furthermore, the two theta 12 rhythms also showed a heterogeneous pattern of phase-amplitude coupling with fast oscillations, 13 reflecting their distinct architecture in underlying neuronal circuitry. Interestingly, in good-14 performance epochs, where visual theta was relatively weak, stronger fronto-visual long-range 15 synchrony and shorter posterior-to-anterior temporal delay were found. These findings highlight a 16 previously overlooked aspect of long-range synchrony between distinct oscillatory entities in the 17 cerebral cortex and provide empirical evidence of a functional dissociation of cortical theta rhythms. 18 19 KEYWORDS 20 Theta rhythms, frontal theta, visual theta, electroencephalogram (EEG), Go/No-Go task 21 22 42 bottom right indicate 500 ms and 300 µV. (D) Summary of behavioral results. From all subjects (five 43 mice), and all sessions (10 days), data of 8,390 trials were collected. In this study, only the trials from CR 44 (n = 2,411) were analyzed. (E and F) (E) Time-frequency representation of grand-averaged event-related 45 spectral perturbation (ERSP) of each cortical area. In both the frontal and visual cortices, prominent theta 46 (4-12 Hz) oscillations were observed during 4 s of stimulus presentation (No-Go period). (F) Temporal 47 average (0.5 to 4 s) of theta oscillations in each cortical area. Numbers denote peak frequency of each 48 channel. FA: false alarm, Fr: frontal cortex, Vis: visual cortex, Amptd: amplitude, Freq: frequency. 49 4 / 35 50 Figure 2. Task performance and theta amplitude 51 (A) Distribution of pc (proportion correct) in all CR trials (n = 2,411). pc was calculated across 10 previous 52 trials. With a threshold of chance level (pc = 0.5), each trial was classified as either attentive (pc > 0.5) or 53 inattentive (pc ≤ 0.5) state. (B) Change of mean RT as function of pc. The RT of Hit trials decreased as pc 54 increased (Pearson's r = -.051, p < .05), suggesting the change of attentional level within the ...

show abstract

Music and Visual Art Training Increase Auditory-Evoked Theta Oscillations in Older Adults

et al. 2022

View full text Add to dashboard Cite

Music training was shown to induce changes in auditory processing in older adults. However, most findings stem from correlational studies and fewer examine long-term sustainable benefits. Moreover, research shows small and variable changes in auditory event-related potential (ERP) amplitudes and/or latencies in older adults. Conventional time domain analysis methods, however, are susceptible to latency jitter in evoked responses and may miss important information of brain processing. Here, we used time-frequency analyses to examine training-related changes in auditory-evoked oscillatory activity in healthy older adults (N = 50) assigned to a music training (n = 16), visual art training (n = 17), or a no-treatment control (n = 17) group. All three groups were presented with oddball auditory paradigms with synthesized piano tones or vowels during the acquisition of high-density EEG. Neurophysiological measures were collected at three-time points: pre-training, post-training, and at a three-month follow-up. Training programs were administered for 12-weeks. Increased theta power was found pre and post- training for the music (p = 0.010) and visual art group (p = 0.010) as compared to controls (p = 0.776) and maintained at the three-month follow-up. Results showed training-related plasticity on auditory processing in aging adults. Neuroplastic changes were maintained three months post-training, suggesting music and visual art programs yield lasting benefits that might facilitate encoding, retention, and memory retrieval.

show abstract

Theta Oscillations Organize Spiking Activity in Higher-Order Visual Thalamus during Sustained Attention

Cited by 4 publications

References 35 publications

Rational design of transcranial alternating current stimulation

Rational design of transcranial alternating current stimulation

Functional dissociation of theta oscillations in the frontal and visual cortices and their long-range network during sustained attention

Music and Visual Art Training Increase Auditory-Evoked Theta Oscillations in Older Adults

Contact Info

Product

Resources

About