Theta-Range Oscillations in Stress-Induced Mental Disorders as an Oscillotherapeutic Target

Okonogi, Toya; Sasaki, Takuya

doi:10.3389/fnbeh.2021.698753

Cited by 24 publications

(11 citation statements)

References 90 publications

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“…Experiments were instead designed to encompass a comparable number of cells as several previous studies of spike-phase computation among prefrontal principal cells (e.g. Karalis et al, 2016 ; Abe et al, 2019 ; Okonogi and Sasaki, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Prefrontal-amygdalar oscillations related to social behavior in mice

Kuga

Abe

Takano

et al. 2022

eLife

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The medial prefrontal cortex and amygdala are involved in the regulation of social behavior and associated with psychiatric diseases but their detailed neurophysiological mechanisms at a network level remain unclear. We recorded local field potentials (LFPs) from the dorsal medial prefrontal cortex (dmPFC) and basolateral amygdala (BLA) while male mice engaged on social behavior. We found that in wild-type mice, both the dmPFC and BLA increased 4–7 Hz oscillation power and decreased 30–60 Hz power when they needed to attend to another target mouse. In mouse models with reduced social interactions, dmPFC 4–7 Hz power further increased especially when they exhibited social avoidance behavior. In contrast, dmPFC and BLA decreased 4–7 Hz power when wild-type mice socially approached a target mouse. Frequency-specific optogenetic manipulations replicating social approach-related LFP patterns restored social interaction behavior in socially deficient mice. These results demonstrate a neurophysiological substrate of the prefrontal cortex and amygdala related to social behavior and provide a unified pathophysiological understanding of neuronal population dynamics underlying social behavioral deficits.

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Section: Methodsmentioning

confidence: 99%

Prefrontal-amygdalar oscillations related to social behavior in mice

Kuga

Abe

Takano

et al. 2022

eLife

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“…The electrode array used in this study has been described elesewhere 40 . An electrode array for brain LFP recording was assembled consisting of custom-made parts (Fig.…”

Section: Methodsmentioning

confidence: 99%

Weak representation of awake/sleep states by local field potentials in aged mice

Konno

Ikegaya

Sasaki

2022

Sci Rep

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Senescence affects various aspects of sleep, and it remains unclear how sleep-related neuronal network activity is altered by senescence. Here, we recorded local field potential signals from multiple brain regions covering the forebrain in young (10-week-old) and aged (2-year-old) mice. Interregional LFP correlations across these brain regions could not detect pronounced differences between awake and sleep states in both young and aged mice. Multivariate analyses with machine learning algorithms with uniform manifold approximation and projection and robust continuous clustering demonstrated that LFP correlational patterns at multiple frequency bands, ranging from delta to high gamma bands, in aged mice less represented awake/sleep states than those in young mice. By housing aged mice in an enriched environment, the LFP patterns were changed to more precisely represent awake/sleep states. Our results demonstrate senescence-induced changes in neuronal activity at the network level and provide insight into the prevention of pathological symptoms associated with sleep disturbance in senescence.

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“… 96 For example, changes in oscillatory power in the PFC in response to social defeat stress has been shown to predict vulnerability to behavioral deficits. 99 Social defeat stress has also been shown to increase 4–8 Hz oscillations between the amygdala and PFC in mice with impaired extinction learning, 99 increase 2–7 Hz oscillations in the PFC in mice exhibiting depression-like behaviors when exposed to the aggressor mouse, 99 and disrupt PFC-mediated synchrony between the amygdala and VTA 100 (for review see 101 ). In addition, previous stress exposure altered the power of gamma oscillations in the nucleus accumbens during social interaction.…”

Section: Impact Of Chronic Stress On Network Statesmentioning

confidence: 99%

Influence of chronic stress on network states governing valence processing: Potential relevance to the risk for psychiatric illnesses

Antonoudiou

Stone

Colmers

et al. 2023

J Neuroendocrinology

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Stress is a major risk factor for psychiatric illnesses and understanding the mechanisms through which stress disrupts behavioral states is imperative to understanding the underlying pathophysiology of mood disorders. Both chronic stress and early life stress alter valence processing, the process of assigning value to sensory inputs and experiences (positive or negative), which determines subsequent behavior and is essential for emotional processing and ultimately survival. Stress disrupts valence processing in both humans and preclinical models, favoring negative valence processing and impairing positive valence processing. Valence assignment involves neural computations performed in emotional processing hubs, including the amygdala, prefrontal cortex, and ventral hippocampus, which can be influenced by neuroendocrine mediators. Oscillations within and between these regions are critical for the neural computations necessary to perform valence processing functions. Major advances in the field have demonstrated a role for oscillatory states in valence processing under physiological conditions and emerging studies are exploring how these network states are altered under pathophysiological conditions and impacted by neuroendocrine factors. The current review highlights what is currently known regarding the impact of stress and the role of neuroendocrine mediators on network states and valence processing. Further, we propose a model in which chronic stress alters information routing through emotional processing hubs, resulting in a facilitation of negative valence processing and a suppression of positive valence processing.

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Theta-Range Oscillations in Stress-Induced Mental Disorders as an Oscillotherapeutic Target

Cited by 24 publications

References 90 publications

Prefrontal-amygdalar oscillations related to social behavior in mice

Prefrontal-amygdalar oscillations related to social behavior in mice

Weak representation of awake/sleep states by local field potentials in aged mice

Influence of chronic stress on network states governing valence processing: Potential relevance to the risk for psychiatric illnesses

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