THF Effect of Acth on THF Survival of Homografts in Man

Baxter, Hamilton; Schiller, Carl; Whiteside, John; Lipshutz, Herbert; Straith, R. E.

doi:10.1097/00006534-195106000-00003

Cited by 10 publications

(3 citation statements)

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“…She had been admitted to this hospital for the first time 7 months before the present admission for drowsiness, vomiting, and oliguria. Good symptomatic improvement was obtained by dialysis with the artificial kidney on two occasions.…”

Section: -View Of the Right Thigh On The Day Of Opera-tion Showing mentioning

confidence: 99%

“…They point out that because all the animals lost weight the results may be due to the poor nutritional status of the treated animals. The effect of ACTH on skin homografts has been debated, but most investigators now feel that it does not significantly prolong the graft take (7,41). Cortisone has been found by some workers to prolong skin graft survival (9,10,15) and by others to have no effect in this regard (41,133,134).…”

Section: Homograft Vesselsmentioning

confidence: 99%

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Experiences With Renal Homotransplantation in the Human: Report of Nine Cases 1

Hume¹,

Merrill²,

Miller³

et al. 1955

J. Clin. Invest.

579

192

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Section: -View Of the Right Thigh On The Day Of Opera-tion Showing mentioning

confidence: 99%

Section: Homograft Vesselsmentioning

confidence: 99%

Experiences With Renal Homotransplantation in the Human: Report of Nine Cases 1

Hume¹,

Merrill²,

Miller³

et al. 1955

J. Clin. Invest.

579

192

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“…of skin homografts in the guinea-pig, it was of interest to see whether ACTH (adreno¬ corticotrophic hormone) had a similar effect, although practically all the evidence points to the ineffectiveness of ACTH in modifying the course of the skin homograft reaction in man [Ellison, Martin, Williams, Clatworthy, Hamwi & Zollinger, 1951;Baxter, Schiller, Whiteside, Lipshutz & Straith, 1951;McNichol, 1952] and experi¬ mental animals [Weisman, Quinby, Wight & Cannon, 1951 ;Allen, Williams, Lovingood & Ellison, 1952;Cannon & Longmire, 1952;Krohn, 1952]. of skin homografts in the guinea-pig, it was of interest to see whether ACTH (adreno¬ corticotrophic hormone) had a similar effect, although practically all the evidence points to the ineffectiveness of ACTH in modifying the course of the skin homograft reaction in man [Ellison, Martin, Williams, Clatworthy, Hamwi & Zollinger, 1951;Baxter, Schiller, Whiteside, Lipshutz & Straith, 1951;McNichol, 1952] and experi¬ mental animals [Weisman, Quinby, Wight & Cannon, 1951 ;Allen, Williams, Lovingood & Ellison, 1952;Cannon & Longmire, 1952;Krohn, 1952].…”

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confidence: 99%

The Effect of Cortisone Alcohol and Acth (Adrenocorticotrophic Hormone) on Skin Homografts in the Guinea-Pig

Sparrow¹

1954

Journal of Endocrinology

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1. Subcutaneous injection twice daily of 5 mg of cortisone alcohol is as effective in prolonging the life of skin homografts in the guinea-pig as the daily administration of 25 mg of cortisone acetate, under the conditions of administration.2. A preparation equivalent to 12\m=.\5mg of ACTH (Armour), when given daily subcutaneously in a slow-release medium (beeswax and arachis oil), gave a prolongation of epithelial survival not less than that obtained with cortisone.3. The course of the homograft reaction in guinea-pigs treated with cortisone alcohol, and in some of those receiving ACTH, was not exactly the same as that produced bycortisone acetate. There was a strong inflammatory reaction in the grafts at an early stage, while the graft epithelium showed vigorous proliferative activity. The grafts on other animals receiving ACTH showed delayed vascularization and leucocytic infiltration with relative quiescence of the epithelium in the early stages. Nevertheless, the general course of the reaction in both cases was of a prolonged vacillating type.4. It is suggested that large supplementary doses of cortisone are required to produce an appreciable prolongation in the survival time of skin homografts in guinea-pigs, because their normal output of 'glucocorticoids' is high and their tissues are relatively insensitive. The efficacy of ACTH in the guinea-pig as compared with other animals, e.g. the rabbit, is at present unexplained.The skin homograft reaction belongs to that class of immunological reactions which are modified by the administration of certain of the adrenocortical hormones. Cortisone acetate is particularly effective in prolonging the life of skin homografts in rabbits [Billingham, Krohn & Medawar, 1951a, b; Morgan, 1951], and has con¬ siderable effect on the skin homograft reaction in other species, e.g. chicks [Cannon & Longmire, 1952], guinea-pigs [Sparrow, 1953] and mice [Medawar & Sparrow, unpubl.].In an earlier series of experiments [Sparrow, 1953] it was established that in general the guinea-pig is less responsive to treatment with cortisone acetate than the rabbit, more than double the absolute dose being required to achieve an equal prolongation in the survival time of skin homografts in this species. The guinea-pig may be deficient in tissue esterases [Humphrey, 1953], and consequently the hydrolysis of cortisone ester to cortisone alcohol (presumably the active form of the hormone) is probably a slow process in this species. Daily subcutaneous injection of a small quantity of cortisone alcohol might therefore be much more effective in modifying the course of the skin homograft reaction than an equimolar amount of cortisone acetate. Experi¬ ments were carried out to see if this was true.

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Die freien Haut-Transplantationen einschließlich der Frage der Homoio -Transplantation

Andina¹

1953

Ergebnisse Der Chirurgie Und Orthopädie

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THF Effect of Acth on THF Survival of Homografts in Man

Cited by 10 publications

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Experiences With Renal Homotransplantation in the Human: Report of Nine Cases 1

Experiences With Renal Homotransplantation in the Human: Report of Nine Cases 1

The Effect of Cortisone Alcohol and Acth (Adrenocorticotrophic Hormone) on Skin Homografts in the Guinea-Pig

Die freien Haut-Transplantationen einschließlich der Frage der Homoio -Transplantation

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