ThGM cells as a prognostic and predictive marker for coronary heart disease

Abstract

Background Coronary heart disease (CHD) is causing by the aberrant aggregation of immune cells in plaque. This study aimed to identify abnormal T cell subtypes and inflammatory factors in CHD patients.Methods and results T cell subsets from 187 CHD patients were analyzed using flow cytometry. Plasma concentration of cytokines were analyzed by Luminex. Flow cytometric analysis revealed that the number of ThGM cells was higher in CHD patients. The proportion of Th17 and Th1 cells were also increased in CHD patients. levels of IL-4, IL-5, IL-6, and IL-10 were significantly higher in CHD patients (P<0.05). However, levels of GM-CSF were slightly lower in CHD patients. Conclusions ThGM can be considered as a diagnostic marker of CDH.