Thiabendazole<i>vs.</i>albendazole in treatment of toxocariasis: a clinical trial

Stürchler, D; Schubarth, P; Gualzata, M; Gottstein, Bruno; Oettli, A.

doi:10.1080/00034983.1989.11812374

Cited by 125 publications

(65 citation statements)

References 12 publications

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“…Side-effects consisting of dizziness, nausea, and vomiting, were observed in 50 per cent (Magnaval and Charlet, 1987) and 60 per cent (Sturchler et al, 1989) of patients.…”

Section: Treatment Of Toxocariasis Drugsmentioning

confidence: 98%

“…When TBZ was given orally every day in doses of 25 mg/kg b/w (Magnaval and Charlet, 1987) to 50 mg/kg b/w (Bass et al, 1987;Sturchler et al, 1989) for 3 to 7 days, an improvement in clinical manifestations was found amongst 50 per cent (Magnaval and Charlet, 1987) to 53 per cent (Sturchler et al, 1989) of the patients. Side-effects consisting of dizziness, nausea, and vomiting, were observed in 50 per cent (Magnaval and Charlet, 1987) and 60 per cent (Sturchler et al, 1989) of patients.…”

Section: Treatment Of Toxocariasis Drugsmentioning

confidence: 99%

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Highlights of human toxocariasis

et al. 2001

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“…Side-effects consisting of dizziness, nausea, and vomiting, were observed in 50 per cent (Magnaval and Charlet, 1987) and 60 per cent (Sturchler et al, 1989) of patients.…”

Section: Treatment Of Toxocariasis Drugsmentioning

confidence: 98%

Section: Treatment Of Toxocariasis Drugsmentioning

confidence: 99%

Highlights of human toxocariasis

et al. 2001

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“…Patients receiving a 5-day treatment course of albendazole (10 mg/kg of body weight/day in two divided doses) improved relative to patients who received treatment with the older anthelminthic drug thiabendazole (55). A dose of 400 mg of albendazole twice a day for 5 days is the currently recommended therapy (21).…”

Section: Treatmentmentioning

confidence: 99%

Toxocariasis: Clinical Aspects, Epidemiology, Medical Ecology, and Molecular Aspects

2003

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Toxocariasis is caused by a series of related nematode species (ascarids) that routinely infect dogs and cats throughout the world. The eggs from these ascarids are common environmental contaminants of human habitation, due largely to the fact that many kinds of dogs and cats serve as pets, while countless others run wild throughout the streets of most urban centers. The eggs, present in dog and cat feces, become infectious within weeks after they are deposited in the local environment (e.g., sandboxes, city parks, and public beaches, etc.). Humans, particularly children, frequently ingest these eggs by accident and become infected. Infection in humans, in contrast to their definitive hosts, remains occult, often resulting in disease caused by the migrating larval stages. Visceral larva migrans (VLM) and ocular larva migrans (OLM) are two clinical manifestations that result in definable syndromes and present as serious health problems wherever they occur. Diagnosis and treatment of VLM and OLM are difficult. These issues are summarized in this review, with emphasis on the ecology of transmission and control of spread to both humans and animals through public health initiatives employing treatment of pets and environmental intervention strategies that limit the areas that dogs and cats are allowed within the confines of urban centers

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“…67 Among the drugs potentially effective in toxocariasis, only benzimidazoles (albendazole, mebendazole and thiabendazole) and diethylcarbamazine have been tested in controlled studies. 137,138 Since 1994, several studies used albendazole at a dose of 10 mg/kg/day, with course ranging from 5, 10, 15, and 21 days. 27,50,67,80,102,139,140 Other authors have used both diethylcarbamazine and thiabendazole and repeated the cycle in some cases.…”

Section: Therapymentioning

confidence: 99%

Toxocaríase: larva migrans visceral em crianças e adolescentes

Carvalho¹,

Rocha²

2011

J. Pediatr. (Rio J.)

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Objectives: To present a detailed investigation of risk factors, symptoms, and laboratory and imaging tests that may be useful to establish the clinical laboratory diagnosis of visceral larva migrans (VLM) in children, demonstrating the importance of diagnosis and treatment to prevent complications in the eyes, liver, and other organs.Sources: Literature review using the MEDLINE and LILACS (1952-2009) databases, selecting the most recent and representative articles on the topic. Summary of the findings:VLM is an infectious disease with non-specific clinical presentation, whose transmission is related to contact with dogs, especially puppies, and which may progress to late systemic complications in vital organs such as the eyes and the central nervous system. IgG (ELISA) anti-T. canis can be used to establish the laboratory diagnosis. Higher cutoff points suggest recent illness and lower cutoff points demonstrate mild infection or infection in remission. Therapeutic response may be assessed by means of eosinophil blood cell count. The present article provides the pediatrician with updated information regarding VLM, a disease of high prevalence worldwide and in Brazil. Conclusions:The diagnosis of VLM depends mainly on the presence of dogs in the child's household, associated with ELISA (IgG anti-T. canis), using excretory-secretory antigens of Toxocara canis. Prospective studies are warranted to assess the best drug therapy. Prevention is the most important strategy because of the high prevalence of T. canis in urban areas. Adult worms live on average 4 months and, after about 6 months, almost all are spontaneously eliminated by the host. 4

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Thiabendazolevs.albendazole in treatment of toxocariasis: a clinical trial

Cited by 125 publications

References 12 publications

Highlights of human toxocariasis

Highlights of human toxocariasis

Toxocariasis: Clinical Aspects, Epidemiology, Medical Ecology, and Molecular Aspects

Toxocaríase: larva migrans visceral em crianças e adolescentes

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