Thiamine and benfotiamine: Focus on their therapeutic potential

Bozic, Iva; Lavrnja, Irena

doi:10.1016/j.heliyon.2023.e21839

Cited by 12 publications

(4 citation statements)

References 93 publications

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“…В многочисленных исследованиях [16,21,29,30,[32][33][34]39] отмечены преимущества применения вместо тиамина в качестве витамина В 1 бенфотиамина -жирорастворимой формы витамина В 1 , которая за счет своих липофильных свойств обеспечивает большую биодоступность тиамина и позволяет достигнуть лечебной концентрации витамина В 1 в крови и нервных клетках.…”

Section: Discussionunclassified

“…Тиамин необходим для правильного функционирования НС, сердца и мышц. Дефицит тиамина -опасное для жизни состояние, приводящее к различным нарушениям и поражениям нервов и головного мозга, по крайней мере у позвоночных [21]. Тиамин является коферментом в реакциях окислительного декарбоксилирования α-кетоглутаровой и пировиноградной кислот, а также принимает активное участие в процессах синтеза белков и механизмах регенерации поврежденной нервной ткани.…”

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“…Он также уменьшает осложнения, наблюдаемые при СД 2, оказывает благотворное воздействие в эксперименте на мышиных моделях нейродегенеративных заболеваний. Бенфотиамин представляет собой готовый агент, используемый для поддержания здоровья нервов, содействия здоровому старению и поддержки метаболизма глюкозы [21].…”

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Effectiveness of use of group B vitamins in patients with diabetic polyneuropathy: A review

Trukhan,

Druk

2024

Consilium Medicum

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Recent decades have been marked by a rapid increase in the number of patients suffering from diabetes. The development and progression of complications of the disease have the greatest impact on the life prognosis of patients with diabetes mellitus. One of the common complications of diabetes mellitus is diabetic polyneuropathy. According to expert estimates, diabetic polyneuropathy develops in 50% of patients with diabetes mellitus and in 10–30% of patients in a prediabetic state. In domestic clinical recommendations and algorithms, the treatment of diabetic polyneuropathy is considered only in terms of drugs used to treat the painful form of diabetic polyneuropathy. In the recommendations of international experts, pathogenetically oriented pharmacotherapy (alpha-lipoic acid and benfotiamine) occupies an important place. As part of the review, we examined the use of B vitamins for the treatment of diabetic polyneuropathy. We searched for relevant sources in the PubMed and Scopus information databases, including the time period up to 12.04.2024. Experience with the use of B vitamins shows that their maximum effectiveness is achieved when they are used in combination, which is due to the complementary effect of each individual vitamin. The use of a combination of vitamins B1, B6 and B12 for diabetic polyneuropathy normalizes reflex reactions, helps eliminate sensitivity disorders, increases the speed of conduction along nerve fibers, and has a moderate analgesic effect.

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Effectiveness of use of group B vitamins in patients with diabetic polyneuropathy: A review

Trukhan,

Druk

2024

Consilium Medicum

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“…Thiamine is a cofactor inhibiting the pentose phosphate. Indeed, evidence has been found that thiamine administration may alleviate oxidative stress, even in cases where it is not attributable to thiamine deficiency [ 124 , 125 ]. Finally, selenium is necessary to glutathione peroxidase activity.…”

Section: Antioxidantsmentioning

confidence: 99%

Oxidative Stress and Cerebral Vascular Tone: The Role of Reactive Oxygen and Nitrogen Species

Salvagno,

Sterchele,

Zaccarelli

et al. 2024

IJMS

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The brain’s unique characteristics make it exceptionally susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production, reactive nitrogen species (RNS) production, and antioxidant defense mechanisms. This review explores the factors contributing to the brain’s vascular tone’s vulnerability in the presence of oxidative damage, which can be of clinical interest in critically ill patients or those presenting acute brain injuries. The brain’s high metabolic rate and inefficient electron transport chain in mitochondria lead to significant ROS generation. Moreover, non-replicating neuronal cells and low repair capacity increase susceptibility to oxidative insult. ROS can influence cerebral vascular tone and permeability, potentially impacting cerebral autoregulation. Different ROS species, including superoxide and hydrogen peroxide, exhibit vasodilatory or vasoconstrictive effects on cerebral blood vessels. RNS, particularly NO and peroxynitrite, also exert vasoactive effects. This review further investigates the neuroprotective effects of antioxidants, including superoxide dismutase (SOD), vitamin C, vitamin E, and the glutathione redox system. Various studies suggest that these antioxidants could be used as adjunct therapies to protect the cerebral vascular tone under conditions of high oxidative stress. Nevertheless, more extensive research is required to comprehensively grasp the relationship between oxidative stress and cerebrovascular tone, and explore the potential benefits of antioxidants as adjunctive therapies in critical illnesses and acute brain injuries.

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Rare Diseases Linked to Mutations in Vitamin Transporters Expressed in the Human Blood–Brain Barrier

Yee,

Wang,

Giacomini

2024

Clin Pharma and Therapeutics

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Recent advances have significantly enhanced our understanding of the role of membrane transporters in drug disposition, particularly focusing on their influence on pharmacokinetics, and consequently, pharmacodynamics. The relevance of these transporters in clinical pharmacology is well acknowledged. Recent research has also underscored the critical role of membrane transporters as targets in human diseases, including their involvement in rare genetic disorders. This review focuses on transporters for water‐soluble B vitamins, such as thiamine, riboflavin, and biotin, essential cofactors for metabolic enzymes. Mutations in transporters, such as SLC19A3 (thiamine), SLC52A2, and SLC52A3 (riboflavin), and SLC5A6 (multiple B vitamins including pantothenic acid and biotin) are linked to severe neurological disorders due to their role in the blood–brain barrier, which is crucial for brain vitamin supply. Current treatments, mainly involving vitamin supplementation, often result in variable response. This review also provides a short perspective on the role of the transporters in the blood‐cerebrospinal fluid barrier and highlights the potential development of pharmacologic treatments for rare disorders associated with mutations in these transporters.

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Thiamine and benfotiamine: Focus on their therapeutic potential

Cited by 12 publications

References 93 publications

Effectiveness of use of group B vitamins in patients with diabetic polyneuropathy: A review

Effectiveness of use of group B vitamins in patients with diabetic polyneuropathy: A review

Oxidative Stress and Cerebral Vascular Tone: The Role of Reactive Oxygen and Nitrogen Species

Rare Diseases Linked to Mutations in Vitamin Transporters Expressed in the Human Blood–Brain Barrier

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