Thiamine and diabetes: back to the future?

Beltramo, Elena; Mazzeo, Aurora; Porta, Massimo

doi:10.1007/s00592-021-01752-4

Cited by 20 publications

(6 citation statements)

References 57 publications

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“…Vitamin B 1 is a cofactor of enzymes involved in PPP; therefore, its use increases among patients with DM [ 30 , 31 , 32 ]. Vitamin B 1 deficiency among DM patients may contribute to the development of diabetic nephropathy [ 16 , 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin B 6 deficiencies are most often correlated with deficiencies of other B vitamins and often affect the elderly and those on HD as well as people with homocysteinemia [ 9 ]. In our previous study, we observed that 40% of HD patients had low dietary vitamin B 6 intake [ 34 ]. Bevier et al found that vitamin B 6 concentrations decreased by 25.4% after one dialysis session [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis

et al. 2023

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The concentration of water-soluble vitamins (except folic acid and vitamin B12) is not routinely measured, which may lead to undiagnosed deficiencies among hemodialysis (HD) patients. The aim of the study was to assess the blood concentration of water-soluble vitamins in HD patients in comparison with healthy subjects and to assess the impact of diabetes mellitus (DM) coexistence on the concentration of these vitamins. The two-center study included 142 HD patients and a control group of 31 healthy subjects. Vitamins concentration was determined using high-performance liquid chromatography (HPLC). Vitamin B1, B6, and B12 levels were significantly lower in the HD group than in the control group (p <0.001). Vitamin B1 and B2 were negatively correlated with blood urea nitrogen (BUN) levels before HD (R = −0.39, R = −0.38; p <0.05). Vitamin B3, B12, and C were positively correlated with the albumin concentration (R = 0.26, R = 0.27, R = 0.28; p <0.05). Among diabetic patients, only the concentration of vitamin B1 was lower than among non-diabetic patients. The concentration of water-soluble vitamins may be related to the adequacy of dialysis, the time of laboratory determination since the last dialysis, diet, coexistence of other diseases, use of drugs, and dietary supplements in individual patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis

et al. 2023

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“…The thiamine transport protein system is primarily responsible for thiamine absorption in the duodenum. Thiamine is transported and delivered into tissues by two transporters, thiamine transporter 1 (THTR1) and thiamine transporter 2 (THTR2) [ 4 ]. The placenta, liver, and kidney are among the tissues that contain high levels of THTR1 and THTR2, but THTR1 is also present in skeletal tissues and cardiac muscles [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Fasting Blood Sugar and Glycated Hemoglobin (HbA1c) With Thiamine Levels in Diabetic Patients

Khan,

Mubeen,

Chohan

et al. 2023

Cureus

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Introduction It has been discovered that low levels of thiamine reserves in the body are related to diabetes mellitus (DM) because thiamine directly influences carbohydrate metabolism. Therefore, the purpose of this study was to assess several metabolic variables and blood thiamine levels in patients with type 1 and type 2 DM and compare them with those in a control group of healthy individuals. Methods This case-control study was conducted at multiple diabetic outpatient centers in Karachi. A total of 90 participants, who were divided into three groups, each containing 30 individuals, were chosen using a convenient non-probability sampling technique. Group A served as the control group and consisted of healthy, non-diabetic individuals. Groups B and C contained subjects with type 1 and type 2 DM, respectively. Descriptive analysis was reported as mean standard deviation, whereas gender and comorbidities were expressed as frequencies and percentages. The chi-square test and Pearson’s correlation coefficient were used to determine the associations of the variables with type 1 DM, type 2 DM, and controls. Results The study results revealed statistically significant differences between controls, type 1 and type 2 DM, in the means of blood glucose levels and all lipid profiles, such as glycated hemoglobin (HbA1c), fasting blood sugar (FBS), random blood sugar (RBS), serum thiamine, triglycerides (p < 0.001), high-density lipoprotein (HDL) (p = 0.014), and total cholesterol (p = 0.013). Furthermore, it was shown that among the control group, type 1 and type 2 DM, HbA1c, and FBS were insignificantly correlated with thiamine levels, whereas the HbA1c and FBS of the combined diabetic groups were significantly correlated with the thiamine level (r = 0.465, p < 0.001) and (r = 0.360, p = 0.005), respectively, where 'r' is the Pearson correlation coefficient. Additionally, HbA1c and FBS in the combined three groups were significantly correlated with the thiamine level (r = −0.626, p < 0.001) and (r = −0.561, p < 0.001), respectively. Conclusion This study concluded that patients with type 1 and type 2 DM had significantly higher levels of FBS, RBS, HbA1c, triglycerides, and total cholesterol than controls. Furthermore, both type 1 and type 2 DM patients’ serum thiamine and HDL levels were observed to be considerably lower than those of controls. Additionally, among both types of DM and controls, there was a strong correlation between FBS and HbA1c. Therefore, we recommend that serum thiamine levels be routinely monitored in diabetic patients, and thiamine supplementation should be considered to avoid complications, especially vascular complications of DM.

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“…Несколько лет спустя роль дефицита тиамина в развитии ДПН стала очевидной, а в некоторых пилотных исследованиях оценивали предполагаемые эффекты добавок тиамина. Однако применение тиамина и его липофильного производного бенфотиамина для лечения данного осложнения получило официальное одобрение только в конце 90-х годов прошлого века [23].…”

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Effectiveness of use of group B vitamins in patients with diabetic polyneuropathy: A review

Trukhan,

Druk

2024

Consilium Medicum

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Recent decades have been marked by a rapid increase in the number of patients suffering from diabetes. The development and progression of complications of the disease have the greatest impact on the life prognosis of patients with diabetes mellitus. One of the common complications of diabetes mellitus is diabetic polyneuropathy. According to expert estimates, diabetic polyneuropathy develops in 50% of patients with diabetes mellitus and in 10–30% of patients in a prediabetic state. In domestic clinical recommendations and algorithms, the treatment of diabetic polyneuropathy is considered only in terms of drugs used to treat the painful form of diabetic polyneuropathy. In the recommendations of international experts, pathogenetically oriented pharmacotherapy (alpha-lipoic acid and benfotiamine) occupies an important place. As part of the review, we examined the use of B vitamins for the treatment of diabetic polyneuropathy. We searched for relevant sources in the PubMed and Scopus information databases, including the time period up to 12.04.2024. Experience with the use of B vitamins shows that their maximum effectiveness is achieved when they are used in combination, which is due to the complementary effect of each individual vitamin. The use of a combination of vitamins B1, B6 and B12 for diabetic polyneuropathy normalizes reflex reactions, helps eliminate sensitivity disorders, increases the speed of conduction along nerve fibers, and has a moderate analgesic effect.

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Thiamine and diabetes: back to the future?

Cited by 20 publications

References 57 publications

Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis

Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis

Correlation of Fasting Blood Sugar and Glycated Hemoglobin (HbA1c) With Thiamine Levels in Diabetic Patients

Effectiveness of use of group B vitamins in patients with diabetic polyneuropathy: A review

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