Thiamine Deficiency and Poverty

Dias, Fernando Machado Vilhena; Oliveira, Aline Sanches; Silva, Danilo Jorge da; Ribeiro, Ângela Maria

doi:10.1007/978-3-319-40007-5_83-1

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…This has predominantly been attributed to the disparities in the nutrient content in the general food supply, dietary habits including relying on low-thiamine staple foods, and avoidance of certain foods [45]. Also, people living in refugee camps, prison populations, and those living in extremely poor conditions are more likely to experience a nutritional shortage, especially of water-soluble nutrients [46,47]. Nonetheless, poor socioeconomic status can itself be an independent risk factor for low thiamine status.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Prevalence of Thiamine Deficiency in Pregnancy and its impact on fetal outcome in an area endemic for thiamine deficiency

et al. 2023

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Background Pregnancy is a metabolically challenging state with increased nutritional demand. Thiamine is an important cofactor in various metabolic pathways and thus its deficiency could have a serious impact on both maternal and fetal outcomes. Kashmir has thiamine deficiency in endemic proportions, with multiple reports of infantile beriberi, postpartum neuropathy, and gastric beriberi. This prompted us to assess the extent of the burden of thiamine deficiency during pregnancy. Methods This cross-sectional study was conducted for a period of two years in pregnant women attending the antenatal clinic. A demographic, clinical, biochemical, and dietary assessment was done in all participants. The whole blood thiamine levels were assessed by high-performance liquid chromatography. Results A total of 492 participants were included in the study with a mean age of 30.30±4.57 years and a mean BMI of 24.25±3.32 Kg/m2. The mean whole blood thiamine level of all participants was 133.29±14.32 nmol/L. Low thiamine status was present in 38.2% (n = 188) of participants. Participants with low thiamine had poor perinatal outcomes, with 3.1% (n = 6) reporting early infant death. Conclusion A high prevalence of thiamine deficiency occurs in pregnant women of Kashmir. Low thiamine is associated with poor nutritional status as well as poor perinatal outcomes. Trial registration CTRI/2022/07/044217.

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Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Prevalence of Thiamine Deficiency in Pregnancy and its impact on fetal outcome in an area endemic for thiamine deficiency

et al. 2023

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“…Psychiatric disease may be a predisposition due to poor intake. It has previously been reported that conditions that lead to poor food intake increase the risk of thiamine deficiency [16][17][18][19]. Thus, improper and unbalanced nutrition for a few days to weeks or more may cause a severe form of thiamine deficiency [3].…”

Section: Discussionmentioning

confidence: 99%

Thiamine deficiency‐related neuropathy: A reversible entity from an endemic area

Nisar,

Yousuf wani,

Altaf

et al. 2023

Euro J of Neurology

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Background and purposeDespite thiamine deficiency being a lesser‐known entity in modern times, beriberi in various forms, including thiamine deficiency‐related neuropathy, remains endemic in Kashmir due to the consumption of polished rice as a staple food. This observational study investigates cases of peripheral neuropathy of unknown etiology and their potential responsiveness to thiamine administration.MethodsThis prospective study enrolled adult patients presenting to the emergency department with weakness consistent with thiamine deficiency‐related neuropathy and conducted a therapeutic challenge with thiamine on 41 patients. Response to thiamine therapy was monitored based on subjective and objective improvements in weakness and power. Patients were divided into thiamine responders (n = 25) and nonresponders (n = 16) based on their response to thiamine therapy and nerve conduction studies.ResultsMost of the baseline characteristics were similar between responders and nonresponders, except the responders exhibited lower thiamine levels and higher partial pressure of oxygen and lactate levels compared to nonresponders. All patients had a history of consuming polished rice and traditional salt tea. Although weakness in the lower limbs was present in both groups, nonresponders were more likely to exhibit weakness in all four limbs. Clinical improvement was observed within 24 h, but proximal muscle weakness persisted for an extended period of time.ConclusionsThiamine deficiency‐related neuropathy presents with predominant lower limb weakness, exacerbated by vomiting, poor food intake, psychiatric illness, and pregnancy. Thiamine challenge should be followed by observation of clinical and biochemical response.

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A Diagnostic Classifier for Prediction of Vitamin and Mineral Deficiency Based on Symptoms and Profiling Its Impact During Pregnancy

Sawant¹,

Jagdish

2021

Lecture Notes in Networks and Systems

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Thiamine Deficiency and Poverty

Cited by 3 publications

References 34 publications

Prevalence of Thiamine Deficiency in Pregnancy and its impact on fetal outcome in an area endemic for thiamine deficiency

Prevalence of Thiamine Deficiency in Pregnancy and its impact on fetal outcome in an area endemic for thiamine deficiency

Thiamine deficiency‐related neuropathy: A reversible entity from an endemic area

A Diagnostic Classifier for Prediction of Vitamin and Mineral Deficiency Based on Symptoms and Profiling Its Impact During Pregnancy

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