Thiamine Deficiency at a District General Hospital: Report of Five Cases

Anderson, S H; Charles, Tommy; Nicol, A. D.

doi:10.1093/oxfordjournals.qjmed.a067850

Cited by 7 publications

(1 citation statement)

References 38 publications

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“…This essential compound also acts as a coenzyme of the enzyme that decarboxylates red tartaric acid. The accumulation of red tartaric acid and lactic acid can cause nervousness, anorexia, circulatory failure, and heart failure [21,22]. Considering these, it can produce feelings of weakness and fatigue, depression, and intestinal problems in some cases.…”

Section: Introductionmentioning

confidence: 99%

The pH-Dependent Controlled Release of Encapsulated Vitamin B1 from Liposomal Nanocarrier

Juhász

Ungor

Várkonyi

et al. 2021

IJMS

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In this work, we firstly presented a simple encapsulation method to prepare thiamine hydrochloride (vitamin B1)-loaded asolectin-based liposomes with average hydrodynamic diameter of ca. 225 and 245 nm under physiological and acidic conditions, respectively. In addition to the optimization of the sonication and magnetic stirring times used for size regulation, the effect of the concentrations of both asolectin carrier and initial vitamin B1 on the entrapment efficiency (EE %) was also investigated. Thermoanalytical measurements clearly demonstrated that after the successful encapsulation, only weak interactions were discovered between the carriers and the drug molecules. Moreover, the dissolution profiles under physiological (pH = 7.40) and gastric conditions (pH = 1.50) were also registered and the release profiles of our liposomal B1 system were compared with the dissolution profile of the pure drug solution and a manufactured tablet containing thiamin hydrochloride as active ingredient. The release curves were evaluated by nonlinear fitting of six different kinetic models. The best goodness of fit, where the correlation coefficients in the case of all three systems were larger than 0.98, was reached by application of the well-known second-order kinetic model. Based on the evaluation, it was estimated that our liposomal nanocarrier system shows 4.5-fold and 1.5-fold larger drug retention compared to the unpackaged vitamin B1 under physiological conditions and in artificial gastric juice, respectively.

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Section: Introductionmentioning

confidence: 99%

The pH-Dependent Controlled Release of Encapsulated Vitamin B1 from Liposomal Nanocarrier

Juhász

Ungor

Várkonyi

et al. 2021

IJMS

View full text Add to dashboard Cite

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Thiamine status after major trauma

McConachie

Haskew

1988

Intensive Care Med

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A prospective study of thiamine status in patients with severe injuries (injury severity scores greater than 12) showed that they all developed signs of severe thiamine deficiency on the basis of transketolase activity, the standard biochemical test for thiamine deficiency. This occurred within the first week after their injuries despite routine enteral or parenteral feeding including vitamin supplements. This may be due to increased requirements secondary to increased metabolic activity or increased cellular losses. An increased awareness of thiamine requirements and metabolism is essential to avoid the appearance of deficiency syndromes.

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Thiamine deficiency in the critically ill

1988

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There have been recent reports of hospitalised patients developing clinical thiamine deficiency, combined with much debate on the optimal supplementation of thiamine for the parenterally fed patient, particularly in the intensive therapy environment. We performed a retrospective study on 158 patients admitted to the Intensive Care Unit who required nutritional support. Patients who survived had significantly higher body thiamine status than those who died (p less than 0.01). There was no difference between serum albumin concentrations of the two groups. Twenty percent of the patients had biochemical evidence of thiamine deficiency and the mortality rate in these patients was 72% as compared with 50% mortality overall. Follow-up results suggest that current levels of thiamine supplementation are insufficient for critically ill intravenously fed patients. We suggest that patients be given a loading dose of 50-250 mg thiamine on admission to the Intensive Care Unit.

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Thiamine Deficiency at a District General Hospital: Report of Five Cases

Cited by 7 publications

References 38 publications

The pH-Dependent Controlled Release of Encapsulated Vitamin B1 from Liposomal Nanocarrier

The pH-Dependent Controlled Release of Encapsulated Vitamin B1 from Liposomal Nanocarrier

Thiamine status after major trauma

Thiamine deficiency in the critically ill

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