Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits in Mice

Li, Hui; Xu, Hong; Wen, Wen; Wu, Liying; Xu, Mei; Luo, Jia

doi:10.3390/brainsci10080565

Cited by 5 publications

(5 citation statements)

References 76 publications

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Section: Resultscontrasting

confidence: 99%

“…This study reveals that vitamin B1 levels partially show no significant effect on anxiety symptoms, contradicting previous research (23,24,27). Previous research has indicated that vitamin B1 deficiency can decrease GABA levels and disrupt serotonin levels in the brain, leading to anxiety symptoms in experimental animals (22,23). The disparity between previous research and this study lies in the research subject, where previous studies used rats as experimental animals, whereas this study involved humans as research subjects.…”

Section: Resultscontrasting

confidence: 99%

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Effect of Thiamine, Bmi, Sleep Duration, and Anxiety in Neurotic, Stress, and Somatoform Disorder

Lintang Mega Pertiwi,

Mohammad Fanani,

Nur Hafidha Hikmayani

2023

MIPHMP

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Neurotic, stress, and somatoform disorders are one of the diagnosis group characterized by anxiety symptoms. Thiamine or vitamin B1 levels, Body Mass Index (BMI), and sleep duration have been associated partially with anxiety disorders in the health population. The aim of this study is to examined the relationship between thiamine levels, BMI, and sleep duration with anxiety symptoms among people with neurotic, stress, and somatoform disorders. This study is observational with cross-sectional design and engage patients with neurotic, stress, and somatoform disorders as participant. The data gathered comprised thimine levels measured using the liquid chromatography-mass spectrometry (LC-MS/MS), BMI measured based on data of the patient's weight and height, and sleep duration obtained through a questionnaire. Anxiety levels were evaluated using the Zung Self-Rating Questionnaire (SAS). Linear regression was performed for data analysis. The findings indicated that there was no significant relationship between vitamin B1 levels and anxiety levels. However, this study suggested that an increase of 1 hour in sleep duration (coefficient = -2.784, p = 0.007) and an increase of 1 unit in BMI (coefficient = -0.824, p = 0.022) were associated with a statistically significant decrease in anxiety index. This study demonstrated significant relationship between BMI and sleep duration with anxiety symptoms in patients with neurotic, stress, and somatoform disorders. Further study is required to understand the mechanisms of this relationship and its implications for the treatment of patients with neurotic, stress, and somatoform disorders.

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Section: Resultscontrasting

confidence: 99%

Section: Resultscontrasting

confidence: 99%

Effect of Thiamine, Bmi, Sleep Duration, and Anxiety in Neurotic, Stress, and Somatoform Disorder

Lintang Mega Pertiwi,

Mohammad Fanani,

Nur Hafidha Hikmayani

2023

MIPHMP

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“…Thiamine deficiency (TD) has long been associated with alcoholism ( Leevy and Baker, 1968 ; Woodhill and Nobile, 1972 ; Butterworth, 1995 ) and has been implicated as a key factor for alcohol-induced brain damages ( Martin et al, 2003 ; Liu et al, 2017 ). Our recent publication indicated thiamine deficiency can cause anxiety-like behaviors ( Li et al, 2020 ). Xu et al showed chronic voluntary alcohol drinking caused a significant decrease in the levels of thiamine in the brain but not the blood of male cHAP mice ( Xu et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Chronic Voluntary Alcohol Drinking Causes Anxiety-like Behavior, Thiamine Deficiency, and Brain Damage of Female Crossed High Alcohol Preferring Mice

Liu

et al. 2021

Front. Pharmacol.

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The central nervous system is vulnerable to chronic alcohol abuse, and alcohol dependence is a chronically relapsing disorder which causes a variety of physical and mental disorders. Appropriate animal models are important for investigating the underlying cellular and molecular mechanisms. The crossed High Alcohol Preferring mice prefer alcohol to water when given free access. In the present study, we used female cHAP mice as a model of chronic voluntary drinking to evaluate the effects of alcohol on neurobehavioral and neuropathological changes. The female cHAP mice had free-choice access to 10% ethanol and water, while control mice had access to water alone at the age of 60-day-old. The mice were exposed to alcohol for 7 months then subjected to neurobehavioral tests including open field (OF), elevated plus maze (EPM), and Morris water maze (MWM). Results from OF and EPM tests suggested that chronic voluntary drinking caused anxiety-like behaviors. After behavior tests, mice were sacrificed, and brain tissues were processed for biochemical analyses. Alcohol altered the levels of several neurotransmitters and neurotrophic factors in the brain including gamma-Aminobutyric acid (GABA), corticotropin-releasing factor, cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor. Alcohol increased the expression of neuroinflammation markers including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and C-C chemokine receptor 2 (CCR2). Alcohol also induced cleaved caspase-3 and glial fibrillary acidic protein, indicative of neurodegeneration and gliosis. In addition, alcohol inhibited the expression of thiamine transporters in the brain and reduced thiamine levels in the blood. Alcohol also caused oxidative stress and endoplasmic reticulum (ER) stress, and stimulated neurogenesis.

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“…Of note, thiamine is a water-soluble vitamin that plays an important role in the biological processes such as glucose metabolism ( Polegato et al, 2019 ). There is evidence showing that the deficiency of the thiamine led to long-term neurobehavioral deficits, such as anxiety disorders ( Li et al, 2020 ). In fact, thiamine supplementation can prevent the occurrence of anxietious behaviors ( Markova et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic effect of YangshenDingzhi granules: Integrated network pharmacology and hippocampal metabolomics

Dai²,

Zheng³

et al. 2022

Front. Pharmacol.

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Anxiety disorder is one of the most common mental diseases. It is mainly characterized by a sudden, recurring but indescribable panic, fear, tension and/or anxiety. Yangshendingzhi granules (YSDZ) are widely used in the treatment of anxiety disorders, but its active ingredients and underlying mechanisms are not yet clear. This study integrates network pharmacology and metabolomics to investigate the potential mechanism of action of YSDZ in a rat model of anxiety. First, potential active ingredients and targets were screened by network pharmacology. Then, predictions were verified by molecular docking, molecular dynamics and western blotting. Metabolomics was used to identify differential metabolites and metabolic pathways. All results were integrated for a comprehensive analysis. Network pharmacology analysis found that Carotene, β-sitosterol, quercetin, Stigmasterol, and kaempferol in YSDZ exert anxiolytic effects mainly by acting on IL1β, GABRA1, PTGS1, ESR1, and TNF targets. Molecular docking results showed that all the affinities were lower than −5 kcal/mol, and the average affinities were −7.7764 kcal/mol. Molecular dynamics simulation results showed that RMSD was lower than 2.5 A, and the overall conformational changes of proteins were small, indicating that the small molecules formed stable complexes with proteins. The results of animal experiments showed that YSDZ exerts anxiolytic effects by regulating GABRA1 and TNF-α, ameliorating pathological damage in hippocampal CA1, and regulating metabolic pathways such as thiamine, cysteine and methionine metabolism, lysine biosynthesis and degradation. Altogether, we reveal multiple mechanisms through which YSDZ exerts its anti-anxiety effects, which may provide a reference for its clinical application and drug development.

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Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits in Mice

Cited by 5 publications

References 76 publications

Effect of Thiamine, Bmi, Sleep Duration, and Anxiety in Neurotic, Stress, and Somatoform Disorder

Effect of Thiamine, Bmi, Sleep Duration, and Anxiety in Neurotic, Stress, and Somatoform Disorder

Chronic Voluntary Alcohol Drinking Causes Anxiety-like Behavior, Thiamine Deficiency, and Brain Damage of Female Crossed High Alcohol Preferring Mice

Anxiolytic effect of YangshenDingzhi granules: Integrated network pharmacology and hippocampal metabolomics

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