2011
DOI: 10.1007/s00392-011-0376-2
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Thiamine supplementation in symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled, cross-over pilot study

Abstract: This study suggests that thiamine supplementation has beneficial effects on cardiac function in patients with diuretic drugs for symptomatic chronic heart failure. Subclinical thiamine deficiency is probably an underestimated issue in these outpatients.

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Cited by 77 publications
(68 citation statements)
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“…Likewise, Schoenenberger et al in a randomized doubleblind placebo-controlled cross-over study in nine symptomatic patients with heart failure were able to demonstrate an increase in left ventricular ejection fraction from 29.5 to 32.8% (p = 0.024) after supplementation with oral thiamine 300 mg/ day for 28 days [20]. There was also a non-significant improvement in walking time in six of nine patients.…”
Section: Effect Of Thiamine Supplementation In Chronic Systolic Heartmentioning
confidence: 93%
See 1 more Smart Citation
“…Likewise, Schoenenberger et al in a randomized doubleblind placebo-controlled cross-over study in nine symptomatic patients with heart failure were able to demonstrate an increase in left ventricular ejection fraction from 29.5 to 32.8% (p = 0.024) after supplementation with oral thiamine 300 mg/ day for 28 days [20]. There was also a non-significant improvement in walking time in six of nine patients.…”
Section: Effect Of Thiamine Supplementation In Chronic Systolic Heartmentioning
confidence: 93%
“…In addition, small sample size and short follow-up period are other limitations. IV intravenous, LVEF left ventricular ejection fraction, EF ejection fraction, RCT randomized controlled trial A meta-analysis of the above-mentioned randomized, double-blind placebo-controlled trials [19,20] showed a small increase in left ventricular ejection fraction (3.28%, 95% CI 0.64-5.93%, I 2 = 0%) with thiamine therapy in heart failure patients compared to placebo [21]. Given the small sample size and inherent limitations within the individual studies, the results of this meta-analysis should be interpreted cautiously.…”
Section: Effect Of Thiamine Supplementation In Chronic Systolic Heartmentioning
confidence: 99%
“…Recent studies have demonstrated that additional attention is needed in the identification of thiamine deficiency (TD) and that thiamine supplementation is necessary not only in intensive care unit patients but also in patients with heart failure [15,17,18]. …”
Section: Introductionmentioning
confidence: 99%
“…In elderly patients with heart failure, loop diuretics to manage fluid and sodium levels can cause hyper-excretion of thiamine [18], thereby increasing the risk of developing thiamine deficiency. Clinical data have shown that thiamine correction in depleted patients can improve left ventricular function as well [19][20][21]. Therefore, prevention of thiamine deficiency should be a routine component in the overall management of this disease [21].…”
Section: Discussionmentioning
confidence: 99%
“…Clinical data have shown that thiamine correction in depleted patients can improve left ventricular function as well [19][20][21]. Therefore, prevention of thiamine deficiency should be a routine component in the overall management of this disease [21]. Furthermore, screening for thiamine deficiency in patients with heart failure should be a regular part of their physician wellness visits especially in those that are elderly, chronically ill, have CHF or on loop diuretics [1].…”
Section: Discussionmentioning
confidence: 99%