Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2

Vahter, Jürgen; Viht, Kaido; Uri, Asko; Manoharan, Ganesh babu; Enkvist, Erki

doi:10.1016/j.bmc.2018.09.003

Cited by 16 publications

(10 citation statements)

References 46 publications

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“…As recent examples (Figure ), thiazole I showed an aggregation‐induced emission effect . Thiazole II was developed as a photoluminescent probe for selective determination of the concentration of protein kinase CK2 . Non‐fluorescent thiazole III showed fluorescent emissions in the presence of organophosphate nerve agent simulants .…”

Section: Figurementioning

confidence: 96%

2‐(2‐Hydroxyphenyl)‐5‐aminothiazoles: Synthesis and Properties Involving Dual Emissions

et al. 2019

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2-(2-Hydroxyphenyl)-5-aminothiazoles were prepared by two different methods to elucidate their photophysical properties. The first synthetic method involved the addition of thioamide dianions derived from secondary thioamides and nBuLi to thioforamides. Alternatively, Pdcatalyzed sequential addition of aromatic groups and diarylamines to commercially available thiazoles led to the precursors of the desired thiazoles. The molecular structures of the resulting thiazoles were determined by X-ray analyses. The thiazoles showed dual-emission in cyclohexane and in the solid state.[a] Prof.

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Section: Figurementioning

confidence: 96%

2‐(2‐Hydroxyphenyl)‐5‐aminothiazoles: Synthesis and Properties Involving Dual Emissions

et al. 2019

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“…The chemosensing platforms involving selenium in a reactive position are popular and take various forms nowadays; there are a variety of such species that we wanted to include but that which we did not in deference to space provide here (See References: [38] (Figure 10), [20,[39][40][41][42][43][44][45][46][47]). The report by Soares-Paulino involves the coordination chemistry of the incipient Pd with the help of selenium binding.…”

Section: Selenium As An Active Site Constituent Of Small Molecule Chemosensorsmentioning

confidence: 99%

Discussions of Fluorescence in Selenium Chemistry: Recently Reported Probes, Particles, and a Clearer Biological Knowledge

et al. 2021

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In this review from literature appearing over about the past 5 years, we focus on selected selenide reports and related chemistry; we aimed for a digestible, relevant, review intended to be usefully interconnected within the realm of fluorescence and selenium chemistry. Tellurium is mentioned where relevant. Topics include selenium in physics and surfaces, nanoscience, sensing and fluorescence, quantum dots and nanoparticles, Au and oxide nanoparticles quantum dot based, coatings and catalyst poisons, thin film, and aspects of solar energy conversion. Chemosensing is covered, whether small molecule or nanoparticle based, relating to metal ion analytes, H2S, as well as analyte sulfane (biothiols—including glutathione). We cover recent reports of probing and fluorescence when they deal with redox biology aspects. Selenium in therapeutics, medicinal chemistry and skeleton cores is covered. Selenium serves as a constituent for some small molecule sensors and probes. Typically, the selenium is part of the reactive, or active site of the probe; in other cases, it is featured as the analyte, either as a reduced or oxidized form of selenium. Free radicals and ROS are also mentioned; aggregation strategies are treated in some places. Also, the relationship between reduced selenium and oxidized selenium is developed.

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“…52 Moreover, while the sensitizer containing sulfur has a longer triplet decay time than the seleniumsubstituted analogue, the probes containing selenium are brighter because they undergo ISC more efficiently, leading to a higher triplet population. 53 The authors expanded their work to a different protein kinase, CK2, 54 and another uorescent dye, 44 using the same underlying method. In this series of studies, the authors have successfully utilized heavy-chalcogen substitution to maintain uorescence using FRET, while additionally inducing a time delay suitable for avoiding signal overlap with bioluminescence when detecting biological analytes.…”

Section: Organochalcogens As Triplet Sensitizersmentioning

confidence: 99%

Photoactivity and optical applications of organic materials containing selenium and tellurium

Hoover

Seferos

2019

Chem. Sci.

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Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2

Cited by 16 publications

References 46 publications

2‐(2‐Hydroxyphenyl)‐5‐aminothiazoles: Synthesis and Properties Involving Dual Emissions

2‐(2‐Hydroxyphenyl)‐5‐aminothiazoles: Synthesis and Properties Involving Dual Emissions

Discussions of Fluorescence in Selenium Chemistry: Recently Reported Probes, Particles, and a Clearer Biological Knowledge

Photoactivity and optical applications of organic materials containing selenium and tellurium

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