2024
DOI: 10.1039/d3md00548h
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Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking

Joseph Hennessy,
Piotr Klimkowski,
Daniel Singleton
et al.

Abstract: We report a new class of carboplatin-TFO hybrid that incorporates a bifunctional alkyne–amine nucleobase monomer called AP-C3-dT that enables dual ‘click’ platinum(ii) drug conjugation and thiazole orange fluorophore coupling.

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