“…To date, the search for 5-HT 7 receptor antagonists has led to the discovery of LY215840 [3], SB-258719 [4], DR4004 [5], SB-269970 [6], and SB-656104-A [7]. Regarding 5-HT 7 receptor agonists, AS-19 [8, 9], MSD-5a [10], LP-44 [11], LP-211 [12], E-55888 [13], and E-57431 [14] have been developed. However, most of these agonists display rather modest selectivity because their affinity for the 5-HT 7 type is only 11-fold higher than for 5-HT 1D in case of AS-19 [13], 28.6-fold higher than for 5-HT 1A in case of MSD-5a [10], and 33-fold higher than for dopamine D2 receptor [15], and 5-14-fold higher than for 5-HT 1B , 5-HT 2B , 5-HT 2C , and 5-HT 5A in case of LP-211 [16].…”