Thiazolo[3,2-a]benzimidazoles: Synthetic Strategies, Chemical Transformations and Biological Activities

Abstract

The present review covers the recent synthetic strategies and chemical transformations of thiazolo[3,2-a]benzimidazoles and it also presents the highlights of the biological activities of these compounds.

Synthesis and Anticancer Evaluation of Some Novel Thiophene, Thieno[3,2‐d]pyrimidine, Thieno[3,2‐b]pyridine, and Thieno[3,2‐e][1,4]oxazepine Derivatives Containing Benzothiazole Moiety

“…Thus, cyclocondensation of 2‐aminonitriles with formamide afforded the corresponding aminopyrimidine derivatives . In the present investigation, compound 2 was obtained through reaction of compound 1 with an excess formamide without solvent.…”

Regioselective reaction of imidazole-2-thiols with N-sulfonylphenyldichloroacetaldimines: en route to novel sulfonylamino-substituted imidazo[2,1-b]thiazoles and thiazolo[3,2-a]benzimidazoles

“…The reaction of 2-mercaptoimidazoles with N-(sulfonyl)phenyldichloroacetaldimines leads to the formation of N-(2-phenylimidazo [2,1-b] [1,3]thiazol-3-yl)arenesulfonamides or N-(2-phenyl [1,3]thiazolo [3,2-a]benzimidazol-3-yl)arenesulfonamides. The advantages of the method for the preparation of the imidazothiazole and thiazolobenzimidazole derivatives are available starting reagents, catalyst-free one-step procedure, and high selectivity.…”

“…1 The prospects for application of biologically active imidazothiazoles stem from their ability of inhibiting or activating the various enzymes and receptors. [2][3][4][5] Importantly, these compounds show antitumor, [6][7][8][9][10][11] antimicrobial, 12,13 antidiabetic, 14 diuretic, 15 antihelmintic, 16 and fungicidal 17 properties.…”

Synthesis of novel thiazole-based 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines as potential antitumor and antifungal agents

“…On the other hand, previous studies have shown that the use of thiazole-based compounds as starting materials in organic synthesis led to the formation of several thiazole-derivatives with a wide spectrum of biological activities [21,22] such as antifungal [23,24], antimicrobial [25e27], antimalarial [28] and anticancer [29e35].…”