Thickening of the walls of deep brain abscesses is associated with macrophage infiltration

Abstract

The present study aimed to compare the thickness of brain abscesses in the deep and the superficial brain and to investigate the factors that influence the capsule of brain abscesses. The thickness of the brain abscess wall was evaluated on imaging. Bacteriological examination was performed on the abscess pus and wall, and immunohistochemical staining was used to count the number of macrophages. Kaplan-Meier curves were used to analyze overall survival. The results indicated that the wall of deep-brain abscesses was thicker than that of superficial abscesses. There was a difference in the extent of macrophage infiltration of deep-and superficial-brain abscess walls, and differences in the extent of macrophage infiltration in the wall of brain abscesses caused by various microorganisms were statistically significant. Of note, among the brain abscesses caused by Staphylococcus, the extent of macrophage/microglia infiltration and the thickness of the wall of the deep-brain abscesses were greater than those of superficial-brain abscesses and there was a positive correlation between the number of macrophages and the thickness of the abscess wall. The overall survival (OS) of patients with deep-brain abscess was not significantly shorter than that of patients with superficial-brain abscess. Furthermore, OS was not significantly different among groups of patients receiving different types of treatment. In conclusion, the wall of deep-brain abscesses is thicker than that of superficial abscesses and the infiltration of macrophages is abundant. The thick wall of abscesses in the deep brain may be associated with macrophage infiltration.

Inhalable GSH-Triggered Nanoparticles to Treat Commensal Bacterial Infection in In Situ Lung Tumors

“…For example, the quantitative results showed that the ratio of the F4/80 marker area in the MSN@DOX-AMP group was only 14.8% of that in the Blank group (Figure D and SI Figure S35), demonstrating that the level of macrophage infiltration decreased. It should be caused by the antimicrobial activity of AMP, as the bacterial infection would result in serious macrophage infiltration. , Additionally, MSN@DOX-AMP would not polarize the macrophage in vitro (SI Figure S36). CD3 expression indicates the level of infiltration of T lymphocytes, and this expression is positively correlated with the activity of specific antitumor immunity .…”

“…It should be caused by the antimicrobial activity of AMP, as the bacterial infection would result in serious macrophage infiltration. 52,53 Additionally, MSN@ DOX-AMP would not polarize the macrophage in vitro (SI Figure S36). CD3 expression indicates the level of infiltration of T lymphocytes, and this expression is positively correlated with the activity of specific antitumor immunity.…”

Brain abscess in immunocompetent patients: recent findings

“…Brain abscess develops into a focal accumulation of pus from an initial localized area of infectious cerebritis with generally five concentric histological zones: a necrotic center; surrounded by a well vascularized capsule corresponding to peripheral inflammatory cells, macrophages, and fibroblasts; a dense collagenous capsule; a layer of neovascularization with cerebritis, and external astrogliosis and cerebral edema. A recent bacterial and immunohistochemical study pointed out that the wall of deep-brain abscesses was significantly thicker than that of superficial brain abscesses with a greater degree of macrophage infiltration [1].…”

“…Recent MRI studies suggest that perfusion (dynamic susceptibility contrast, DSC) may help discriminate brain abscesses from malignant lesions [1]. Low relative Cerebral Blood Flow (rCBV) is a good indicator of a brain abscess, whereas a tumor typically has higher rCBV, reflecting neoangiogenesis.…”

“…a Acute acquired risk factors. [1]. Low relative Cerebral Blood Flow (rCBV) is a good indicator of a brain abscess, whereas a tumor typically has higher rCBV, reflecting neoangiogenesis.…”