Thickness of subcutaneous fat is a risk factor for incisional surgical site infection in acute appendicitis surgery: a prospective study

Thapa, B; Sutanto, Edward; Bhandari, Rita

doi:10.1186/s12893-020-01029-7

Cited by 9 publications

(6 citation statements)

References 33 publications

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“…In the present study, downregulation of miR-381-3p was detected in the serum of patients with AD, suggesting its potential role in the disease progression. Consistently, Thapa et al [21] have also reported the low expression of miR-381-3p in the plasma of AD patients, which supported our present findings. The ROC curve is widely used to describe the inherent truthfulness of diagnostic tests.…”

Section: Discussion/conclusionsupporting

confidence: 93%

Differential Expression of miR-381-3p in Alzheimer’s Disease Patients and Its Role in Beta-Amyloid-Induced Neurotoxicity and Inflammation

Zhang

Liu

Teng

et al. 2021

Neuroimmunomodulation

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Introduction: This study aimed to explore the diagnostic value and effect of miR-381-3p on Alzheimer’s disease (AD). Methods: RT-qPCR was used for the measurement of miR-381-3p levels. Pearson correlation coefficient was used for the correlation analysis. Receiver operating characteristic (ROC) curve was constructed to assess the distinct ability of miR-381-3p for AD. SH-SY5Y cells were treated with Aβ25-35 to establish an AD cell model. The role of miR-381-3p on cell proliferation and apoptosis was detected. ELISA was applied to detect the protein levels of inﬂammatory cytokine expression. The target relationship of miR-381-3p with PTGS2 was verified by luciferase reporter gene assay. Results: Low expression of miR-381-3p was detected in the serum of AD patients and cell models. There was a negative association of serum miR-381-3p with the serum inflammatory cytokines. The ROC curve demonstrated the distinct ability of serum miR-381-3p for AD, with the AUC value of 0.898, with a sensitivity of 87.5%, and a specificity of 77.7%. Overexpression of miR-381-3p reversed the influence of Aβ25-35 on cell proliferation and apoptosis, but miR-381-3p downregulation exacerbated the influence. miR-381-3p overexpression inhibited the release of IL-6, IL-1β, and TNF-α induced by Aβ25-35 treatment, whereas miR-381-3p downregulation further promoted the release of inflammatory cytokines. PTGS2 was the target gene of miR-381-3p and was upregulated in AD cell models. Conclusion: miR-381-3p is less expressed in the serum of AD patients and has potential diagnostic values for AD. Overexpression of miR-381-3p may attenuate Aβ25-35-induced neurotoxicity and inflammatory responses via targeting PTGS2 in SH-SY5Y cells.

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Section: Discussion/conclusionsupporting

confidence: 93%

Differential Expression of miR-381-3p in Alzheimer’s Disease Patients and Its Role in Beta-Amyloid-Induced Neurotoxicity and Inflammation

Zhang

Liu

Teng

et al. 2021

Neuroimmunomodulation

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“…Another peculiar feature of our study was the method of measurement of SFT. Our method of direct intraoperative measurement is simple and cost-effective when compared to various radiological methods (CT, USG) used in previous studies [8][9][10][11][12]. This method can be reliably used to measure SFT for predicting SSI, especially in low-resource settings.…”

Section: Discussionmentioning

confidence: 93%

Relevance of Subcutaneous Fat Thickness as a Risk Factor for Surgical Site Infections in Abdominal Surgeries

Teppa¹,

Sude²,

Karanam³

et al. 2022

Cureus

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Incisional surgical site infection is an important cause of postoperative morbidity which results in extended hospital stay and may result in future incisional hernia. We intended to evaluate the thickness of subcutaneous fat with a cut-off value of 2.5cm as a risk factor in causing surgical site infection using a simple, cost-effective, and direct intraoperative method for measuring subcutaneous fat thickness. MethodsA total of 147 patients who underwent abdominal surgeries from September 2017 to April 2019 were included in this prospective study. A proforma was used to collect information of all patients regarding various variables. Abdominal subcutaneous fat thickness was measured in the supine position intraoperatively with a measuring scale from below dermis to rectus sheath at 1cm caudal to umbilicus level. ResultsThe study's overall incidence of incisional surgical site infection (SSI) in laparotomy surgeries was 10.8%. Subcutaneous fat thickness was independently associated with incisional SSI. Subcutaneous fat thickness association with SSI was more statistically significant than that of BMI. The other associated risk factors were found to be obesity, diabetes, and emergency surgery. ConclusionOur results suggest that the risk of incisional SSI increases with the increased subcutaneous fat thickness of more than 2.5cm. Placement of subcutaneous drain in patients undergoing laparotomy with increased subcutaneous fat thickness plays a significant role in reducing the incidence of surgical site infection. Risk of SSI increases in obesity, diabetes, increased age group, dirty surgery, and emergency surgeries. Subcutaneous fat thickness is an independent risk factor for surgical site infection and subcutaneous drain decreases the risk of SSI in thick subcutaneous fat.

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“…This mechanism of delayed fascial closure and wound healing may be a contributing factor in the development of PSH. Second, thick subcutaneous fat is a known risk factor for surgical site infections (SSIs)[ 22 ]. Dense subcutaneous fat makes it difficult for surgeons to obtain an adequate surgical field during abdominal surgery, thus necessitating a larger surgical incision.…”

Section: Discussionmentioning

confidence: 99%

High Subcutaneous Fat Area Is an Independent Risk Factor for Parastomal Hernia after Transperitoneal Colostomy for Colorectal Cancer

Aida,

Kamada,

Takahashi

et al. 2024

J Anus Rectum Colon

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Objectives: Parastomal hernia (PSH) is a common complication of colostomy; however, its risk factors remain poorly investigated. In this study, we examined the associations between sarcopenia, visceral and subcutaneous fat, and PSH in patients who underwent transperitoneal colostomy for colorectal cancer. Methods: This retrospective, single-center, cohort study included 60 patients who underwent laparoscopic or robot-assisted abdominoperineal resection or Hartmann's procedure for colorectal cancer between November 2010 and February 2022. Stoma creation was uniformly performed using the transperitoneal approach, and PSH was diagnosed via abdominal computed tomography (CT) at 1 year postoperatively. Visceral fat areas (VFAs) and subcutaneous fat areas (SFAs) were measured through preoperative CT images using an image analysis system. Risk factors for PSH were retrospectively analyzed. Results: PSH was diagnosed in 13 (21.7%) patients. In the univariate analysis, PSH was significantly associated with body mass index >22.3 kg/m 2 ( p =0.002), operation time >319 min ( p =0.027), estimated blood loss >230 mL ( p =0.008), postoperative complications ( p =0.028), stoma diameter >18.6 mm ( p =0.015), VFA >89.2 cm 2 ( p =0.005), and SFA >173.2 cm 2 ( p =0.001). Multivariate analyses confirmed that SFA >173.2 cm 2 (odds ratio: 16.7, 95% confidence interval 1.29-217.2, p =0.031) was an independent risk factor for PSH. Conclusions: Subcutaneous fat area is significantly associated with the development of PSH after transperitoneal colostomy. Applying these insights could help to prevent PSH.

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Thickness of subcutaneous fat is a risk factor for incisional surgical site infection in acute appendicitis surgery: a prospective study

Cited by 9 publications

References 33 publications

Differential Expression of miR-381-3p in Alzheimer’s Disease Patients and Its Role in Beta-Amyloid-Induced Neurotoxicity and Inflammation

Differential Expression of miR-381-3p in Alzheimer’s Disease Patients and Its Role in Beta-Amyloid-Induced Neurotoxicity and Inflammation

Relevance of Subcutaneous Fat Thickness as a Risk Factor for Surgical Site Infections in Abdominal Surgeries

High Subcutaneous Fat Area Is an Independent Risk Factor for Parastomal Hernia after Transperitoneal Colostomy for Colorectal Cancer

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