Thicknesses of Sclera and Lamina Cribrosa in Patients With Central Retinal Vein Occlusion

Adıyeke, Seda Karaca; Kutlu, Neslisah; Aytoğan, Hasan; Aras, Buket; Yoyler, Gokhan; Türe, Gamze; Talay, Ekrem; Dayangac, Gulsah Talay

doi:10.1097/iae.0000000000002712

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…We did not utilize optical coherence tomography angiography to quantitatively analyze choroidal vasculature to further validate our speculations.3. The sample size was small, and due to the different pathogenic mechanisms of BRVO and CRVO [24] , our study only included BRVO patients, lacking research on CRVO patients.4. This study lacks research on the optic disc morphology and blood ow in patients with BRVO.…”

Section: Discussionmentioning

confidence: 99%

The measurement and correlation analysis of scleral and choroid thickness in branch retinal vein occlusion

Yu,

Zou,

Mao

et al. 2024

Preprint

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Objective: To use Optical Coherence Tomography (OCT) to measure scleral thickness (ST) and subfoveal choroid thickness (SFCT) in patients with Branch Retinal Vein Occlusion (BRVO) and to conduct a correlation analysis. Methods: A cross-sectional study was conducted. From May 2022 to December 2022, a total of 34 cases (68 eyes) of untreated unilateral Branch Retinal Vein Occlusion (BRVO) patients were recruited at the Affiliated Eye Hospital of Nanchang University. Among these cases, 31 were temporal branch vein occlusions, 2 were nasal branch occlusions, and 1 was a superior branch occlusion. Additionally, 39 cases (39 eyes) of gender- and age-matched control eyes were included in the study. Anterior Segment Optical Coherence Tomography (AS-OCT) was used to measure ST at 6mm above, below, nasal, and temporal to the limbus, while Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT) was used to measure SFCT. The differences in ST and SFCT between the affected eye, contralateral eye, and control eye of BRVO patients were compared and analyzed for correlation. Results: The axial lengths of the affected eye, contralateral eye, and control group were (22.92±0.30) mm, (22.89±0.32) mm and (22.90±0.28) mm respectively, with no significant difference in axial length between the affected eye and contralateral eye (P>0.05). The SFCT and ST measurements in different areas showed significant differences between the affected eye, contralateral eye in BRVO patients (P<0.05). In comparison between BRVO-affected eyes and control eyes, there were no statistically significant differences in age and axial length between the two groups (P>0.05). However, significant differences were observed in SFCT and temporal, nasal, superior, and inferior ST between the two groups (P<0.05). When comparing SFCT and ST between BRVO-affected eyes with and without macular edema, no statistically significant differences were found (t=-1.10, 0.45, -1.30, -0.30, 1.00; P=0.28, 0.66, 0.21, 0.77, 0.33). Correlation analysis indicated a significant positive correlation between SFCT and temporal ST in BRVO patients (r=0.288, P=0.049), while no correlation was found between SFCT and nasal, superior, and inferior ST (P>0.05). Conclusion: In BRVO patients, both SFCT and ST increase, and there is a significant correlation between SFCT and the ST at the site of vascular occlusion.

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Section: Discussionmentioning

confidence: 99%

The measurement and correlation analysis of scleral and choroid thickness in branch retinal vein occlusion

Yu,

Zou,

Mao

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…We did not utilize optical coherence tomography angiography to quantitatively analyze choroidal vasculature to further validate our speculations.3. The sample size was small, and due to the different pathogenic mechanisms of BRVO and CRVO 24 , our study only included BRVO patients, lacking research on CRVO patients.4. This study lacks research on the optic disc morphology and blood flow in patients with BRVO.…”

Section: Discussionmentioning

confidence: 99%

The measurement and correlation analysis of scleral and choroid thickness in branch retinal vein occlusion

Yu,

Zou,

Mao

et al. 2024

Sci Rep

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To use Optical Coherence Tomography (OCT) to measure scleral thickness (ST) and subfoveal choroid thickness (SFCT) in patients with Branch Retinal Vein Occlusion (BRVO) and to conduct a correlation analysis. A cross-sectional study was conducted. From May 2022 to December 2022, a total of 34 cases (68 eyes) of untreated unilateral Branch Retinal Vein Occlusion (BRVO) patients were recruited at the Affiliated Eye Hospital of Nanchang University. Among these cases, 31 were temporal branch vein occlusions, 2 were nasal branch occlusions, and 1 was a superior branch occlusion. Additionally, 39 cases (39 eyes) of gender- and age-matched control eyes were included in the study. Anterior Segment Optical Coherence Tomography (AS-OCT) was used to measure ST at 6 mm superior, inferior, nasal, and temporal to the limbus, while Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT) was used to measure SFCT. The differences in ST and SFCT between the affected eye, contralateral eye, and control eye of BRVO patients were compared and analyzed for correlation. The axial lengths of the BRVO-affected eye, contralateral eye, and control group were (22.92 ± 0.30) mm, (22.89 ± 0.32) mm and (22.90 ± 0.28) mm respectively, with no significant difference in axial length between the affected eye and contralateral eye (P > 0.05). The SFCT and ST measurements in different areas showed significant differences between the BRVO-affected eye, contralateral eye in BRVO patients (P < 0.05). The CRT of BRVO-affected eyes was significantly higher than that of the contralateral eyes and the control eyes (P < 0.001). In comparison between BRVO-affected eyes and control eyes, there were no statistically significant differences in age and axial length between the two groups (P > 0.05). However, significant differences were observed in SFCT and temporal, nasal, superior, and inferior ST between the two groups (P < 0.05). The difference in temporal ST between the contralateral eyes and the control eyes was not statistically significant (t = − 0.35, P = 0.73). However, the contralateral group showed statistically significant increases in SFCT, nasal, superior and inferior ST compared to control eyes (t = − 3.153, 3.27, 4.21, 4.79, P = 0.002, 0.002, < 0.001, < 0.001). However, the difference between the CRT of the contralateral and control eyes was not statistically significant (P = 0.421). When comparing SFCT and ST between BRVO-affected eyes with and without macular edema, no statistically significant differences were found (t = − 1.10, 0.45, − 1.30, − 0.30, 1.00; P = 0.28, 0.66, 0.21, 0.77, 0.33). The thickness of SFCT and temporal ST in major BRVO group is higher than the macular BRVO group and the difference was statistically significant (t = 6.39, 7.17, P < 0.001 for all). Pearson correlation analysis revealed that in BRVO patients, there was a significant positive correlation between SFCT/CRT and temporal ST (r = 0.288, 0.355, P = 0.049, 0.04). However, there was no correlation between SFCT/CRT and nasal ST, superior ST, and inferior ST (P > 0.05). In BRVO patients, both SFCT/CRT and ST increase, and there is a significant correlation between SFCT/CRT and the ST at the site of vascular occlusion.

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“…From the RVO perspective, Adiyeke et al recently found that the occlusion of the central retinal vein is also associated with a thickened sclera 16 . Decompression of the scleral outlet via radial neurotomy showed bene cial results 17 .…”

Section: Discussionmentioning

confidence: 99%

Pachychoroid Disease And Its Association With Retinal Vein Occlusion

Keidel¹,

Zwingelberg²,

Schworm³

et al. 2021

Preprint

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The development of a retinal vein occlusion (RVO) is multifactorial. This study investigates pachychoroid as a risk factor for RVO or as an entity sharing common pathophysiology with RVO. A database screening at the University Eye Hospital, Ludwig-Maximilian University Munich, Germany was performed for patients diagnosed with central or branch RVO (CRVO/BRVO). In every patient a complete ophthalmologic examination was performed, including posterior segment enhanced depth spectral domain optical coherence tomography (EDI-SD-OCT). The SD-OCT scans of respective partner eyes without history of RVO were compared to an age and -refraction-matched, randomly recruited normal control group.In total, 312 eyes of 312 patients were included in this study, with 162 eyes in the RVO and 150 eyes in the control group. A significantly higher subfoveal choroidal thickness (SFCT) was found in the RVO (310.3 ± 72.5 (94 to 583) µm) as compared to the control group (237.0 ± 99.0 (62 to 498); p<0.00001). Moreover, the RVO group showed a significantly higher prevalence of a symptomatic pachychoroid (22 vs. 9 eyes; odds ratio: 2.46; 95 CI: 1.10 to 5.53; p=0.029). Since pachychoroid disease represents a bilateral entity, it might be a risk factor for RVO, or share risk factors with RVO.

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Thicknesses of Sclera and Lamina Cribrosa in Patients With Central Retinal Vein Occlusion

Cited by 7 publications

References 18 publications

The measurement and correlation analysis of scleral and choroid thickness in branch retinal vein occlusion

The measurement and correlation analysis of scleral and choroid thickness in branch retinal vein occlusion

The measurement and correlation analysis of scleral and choroid thickness in branch retinal vein occlusion

Pachychoroid Disease And Its Association With Retinal Vein Occlusion

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