Thicknesses of the retinal layers in patients with Graves’ disease with or without orbitopathy

Öğmen, Berna; Uğurlu, Nagihan; Bilginer, Muhammet Cuneyt; Polat, Şefika Burçak; Genc, Birgül; Ersoy, Reyhan; Çakır, Bekir

doi:10.1007/s10792-022-02339-w

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…One study found a statistically significant difference between TED patients and controls, while three studies found no difference. [ 12 22 29 30 ] Guo et al . found a significant decrease in combined GCL and IPL thickness between patients with DON or moderate TED and controls by 11.4% and 5.4%, respectively, but no difference between mild TED and controls.…”

Section: Resultsmentioning

confidence: 99%

Changes in retinal nerve fiber layer, ganglion cell complex, and ganglion cell layer thickness in thyroid eye disease: A systematic review

Briceno¹,

Chien²,

Go³

et al. 2023

Taiwan Journal of Ophthalmology

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Thyroid eye disease (TED) is characterized by progressive orbital inflammation. In severe cases, it can lead to dysthyroid optic neuropathy (DON), involving death of retinal ganglion cells and permanent vision loss. Imaging with optical coherence tomography (OCT) has enabled noninvasive examination of the structural impact of the disease, including of the retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), and the inner plexiform layer (IPL). In this study, we systematically review 20 studies (897 patients, 1430 eyes) to evaluate changes in retinal thickness in patients with TED, stratified by severity. Most studies found a decrease in thickness in peripapillary RNFL (pRNFL), non-pRNFL, combined RNFL/GCL/IPL, or combined GCL/IPL when comparing patients with DON to healthy controls or to patients without DON. However, results were equivocal regarding differences between non-DON TED patients and controls. In addition, several studies reported a postoperative decrease in pRNFL thickness after orbital decompression surgery. Future studies examining OCT changes of retinal thickness along with disease progression are needed to assess the potential of OCT in diagnosis and management of patients with TED.

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Section: Resultsmentioning

confidence: 99%

Changes in retinal nerve fiber layer, ganglion cell complex, and ganglion cell layer thickness in thyroid eye disease: A systematic review

Briceno¹,

Chien²,

Go³

et al. 2023

Taiwan Journal of Ophthalmology

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“…However, the difference in the overall RNFL thickness between the groups with GO and GO IOP was not significant. Other studies also observed RNFL thinning in GO patients without clinical optic nerve dysfunction, particularly in the inferior quadrant [12,16,29]. This suggests the possibility that RNFL damage may occur independently of IOP, and that structural RNFL impairments may exist even in clinically normal findings.…”

Section: Structural and Functional Changesmentioning

confidence: 86%

“…In GO, analysing RNFL helps identify consequences of orbital congestion, optic neuropathy, and changes related to secondary glaucoma. The overall thickness of the RNFL in patients with GO was lower than normal values in the general population [ 29 , 30 ]. However, the difference in the overall RNFL thickness between the groups with GO and GO IOP was not significant.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Structural and Functional Changes in Patients with Raised Intraocular Pressure Due to Graves’ Orbitopathy

Bagatin,

Prpić,

Škunca Herman

et al. 2024

Diagnostics

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This study explores the complication of secondary intraocular pressure (IOP) elevation and consequent glaucoma development in Graves’ orbitopathy (GO), an autoimmune disorder associated with hyperthyroidism. Utilizing Octopus 900 visual field testing and optical coherence tomography (OCT), the research established correlations between functional and structural changes in optic nerve regions in patients with GO and patients with GO with elevated IOP (GO IOP) groups. A comparison with primary open-angle glaucoma (POAG) was conducted in a cohort of 182 subjects. The study identifies optic nerve head parameters that effectively differentiate changes in GO and GO IOP groups. In the GO group, the strongest correlation between structural and functional changes was observed in sector 7, while in the GO IOP group, it was in sectors 1 and 7. For POAG, correlation was found in six sectors. Elevated IOP in GO correlates with structural and functional impairments similarly to early glaucoma. Risk factors for GO-related elevated IOP included older age, longer duration of thyroid disease, and higher anti-thyroglobulin values. The study highlights the significance of regular IOP measurements, visual field assessments, and OCT examinations in GO patients. Early antiglaucoma intervention is warranted when characteristic structural and functional changes and/or risk factors are identified.

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Thyroid Eye Disease and Glaucoma: A Cross-Sectional Study Comparing Clinical Characteristics and Disease Severity

Ghenciu,

Șișu,

Stoicescu

et al. 2024

Medicina

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Background and Objectives: This study investigates the relationship between thyroid eye disease (TED) and open-angle glaucoma (OAG), focusing on disease severity and clinical features. Materials and Methods: Conducted at the Timis County Emergency Clinical Hospital, the research included 106 patients, with 53 having both conditions and 53 having only OAG. Key metrics analyzed included intraocular pressure (IOP) using a Goldmann applanation tonometer, the retinal nerve fiber layer (RNFL) thickness, and optic nerve head (ONH) characteristics evaluated using optical coherence tomography (OCT). Results: Results indicated that patients with both TED and OAG experienced a 6.09% reduction in RNFL thickness and showed more rapid disease progression, with 48.35% having active TED. The mean IOP in TED patients was 27.5 ± 4.9 mmHg, which was similar to those with only OAG. Demographic factors, including age and gender, influenced the clinical course and disease severity. Conclusions: These findings underscore the importance of specialized monitoring and treatment strategies for patients with coexisting TED and OAG to prevent vision loss.

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Thicknesses of the retinal layers in patients with Graves’ disease with or without orbitopathy

Cited by 3 publications

References 45 publications

Changes in retinal nerve fiber layer, ganglion cell complex, and ganglion cell layer thickness in thyroid eye disease: A systematic review

Changes in retinal nerve fiber layer, ganglion cell complex, and ganglion cell layer thickness in thyroid eye disease: A systematic review

Correlation between Structural and Functional Changes in Patients with Raised Intraocular Pressure Due to Graves’ Orbitopathy

Thyroid Eye Disease and Glaucoma: A Cross-Sectional Study Comparing Clinical Characteristics and Disease Severity

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