Thigh-length versus below-knee compression elastic stockings for prevention of the postthrombotic syndrome in patients with proximal-venous thrombosis: a randomized trial

Prandoni, Paolo; Noventa, Franco; Quintavalla, Roberto; Bova, Carlo; Cosmi, Benilde; Siragusa, Sergio; Bucherini, Eugenio; Astorri, Francesco; Cuppini, Stefano; Valle, Fabio Dalla; Lensing, Anthonie W. A.; Prins, Martin H.; Villalta, Sabina

doi:10.1182/blood-2011-11-391961

Cited by 72 publications

(33 citation statements)

References 20 publications

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“…For patients with coexistent DVT, legs can be assessed for post-thrombotic syndrome and the use of compression stockings discussed. Current evidence does not show any benefit for above-knee stockings compared with those that extend to below the knee [78]. Compression stockings are recommended to be worn for 2 years after a DVT and for longer if signs of venous insufficiency persist [8].…”

Section: Inpatient Versus Outpatient Management Of Pementioning

confidence: 99%

Developments in the management and treatment of pulmonary embolism

Limbrey

Howard

2015

Eur Respir Rev

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Pulmonary embolism (PE) is a serious and costly disease for patients and healthcare systems. Guidelines emphasise the importance of differentiating between patients who are at high risk of mortality (those with shock and/or hypotension), who may be candidates for thrombolytic therapy or surgery, and those with less severe presentations. Recent clinical studies and guidelines have focused particularly on risk stratification of intermediate-risk patients. Although the use of thrombolysis has been investigated in these patients, anticoagulation remains the standard treatment approach. Individual risk stratification directs initial treatment. Rates of recurrence differ between subgroups of patients with PE; therefore, a review of provoking factors, along with the risks of morbidity and bleeding, guides the duration of ongoing anticoagulation. The direct oral anticoagulants have shown similar efficacy and, in some cases, reduced major bleeding compared with standard approaches for acute treatment. They also offer the potential to reduce the burden on patients and outpatient services in the post-hospital phase. Rivaroxaban, dabigatran and apixaban have been shown to reduce the risk of recurrent venous thromboembolism versus placebo, when given for >12 months. Patients receiving direct oral anticoagulants do not require regular coagulation monitoring, but follow-up, ideally in a specialist PE clinic in consultation with primary care providers, is recommended. @ERSpublications Direct oral anticoagulants have the potential to improve management of patients with pulmonary embolism http://ow.ly/NV7K6

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Section: Inpatient Versus Outpatient Management Of Pementioning

confidence: 99%

Developments in the management and treatment of pulmonary embolism

Limbrey

Howard

2015

Eur Respir Rev

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“…39 Prandoni and colleagues recently reported that below-knee elastic compression stockings were as effective as and better tolerated than thigh-length stockings for prevention of PTS after DVT. 40 These findings are important because patient adherence is a limiting factor in the use of compression stockings to prevent PTS.…”

Section: Elastic Compression Stockingsmentioning

confidence: 97%

Postthrombotic Syndrome

Galanaud¹,

Kahn²

2013

Consultative Hemostasis and Thrombosis

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“…Three studies have found a significant preventive effect of compression and two did not . Other studies were focused on either shortened duration of therapy or late onset of therapy or on comparative effectiveness of different types of compression stockings …”

Section: Barriers To Progress and Future Perspectivesmentioning

confidence: 99%

“…24,25 Other studies were focused on either shortened duration of therapy 28,29 or late onset of therapy 9 or on comparative effectiveness of different types of compression stockings. 30 Over the years, several meta-analyses have been published on this topic. [31][32][33] Different choices were made concerning the studies that were included, such as the diagnostic strategy used for PTS, the emphasis placed on the assessment of compliance to therapy, and the methodological quality of the studies.…”

Section: One Standard Treatment For All Patientsmentioning

confidence: 99%

Prevention and treatment of the post‐thrombotic syndrome

Cate‐Hoek

2018

Research and Practice in Thrombosis and Haemostasis

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Essentials Post thrombotic syndrome (PTS) is a complication of deep vein thrombosis (DVT) with limited treatment options.Uniformity of the diagnostic strategy and the use of risk prediction models might improve treatment outcomes.Extending knowledge on the pathophysiology and improving therapeutic options is paramount for progress. PTS management should evolve to a multimodal approach with treatment tailored to individual patients' needs. Post thrombotic syndrome (PTS) is a common chronic complication of deep vein thrombosis of the leg (DVT). Treatment options are limited therefore emphasis is placed on its prevention. Several risk factors have been recognized, but were so far not used for risk stratification or translation into prediction models. Early interventions did not yet result in more successful preventive treatment strategies; for the acute phase of DVT there is equipoise on the value of elastic compression, as well as on catheter directed thrombolysis. There are no drugs specifically targeted at PTS prevention. The use of anticoagulant medication such as direct oral anticoagulants (DOACs) might decrease PTS incidence, but this needs to be corroborated. Both research into more effective treatment options as well as future PTS management may benefit from a uniform diagnostic strategy and the use of prediction rules to better allocate treatment and thereby increase treatment efficacy.

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Thigh-length versus below-knee compression elastic stockings for prevention of the postthrombotic syndrome in patients with proximal-venous thrombosis: a randomized trial

Cited by 72 publications

References 20 publications

Developments in the management and treatment of pulmonary embolism

Developments in the management and treatment of pulmonary embolism

Postthrombotic Syndrome

Prevention and treatment of the post‐thrombotic syndrome

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