Thin films for tissue engineering applications

Mozafari, Masoud; Ramedani, Arash; Zhang, Y.N.; Mills, David K.

doi:10.1016/b978-1-78242-453-6.00008-0

Cited by 19 publications

(9 citation statements)

References 111 publications

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“…Surface bioactivity (or biocompatibility) is an important property of materials, so it is very important to control the surface properties of biomaterials and to ensure their biocompatibility and bioactivity. Organic films and coatings, especially polymer films, are most commonly used in biomaterials, because they can be combined on the surface of chemical groups or carry out pattern modification to improve biocompatibility and bioactivity [105].…”

Section: Polymer Thin Filmsmentioning

confidence: 99%

Recent advance in surface modification for regulating cell adhesion and behaviors

Cai

Yang

et al. 2020

Nanotechnology Reviews

423

247

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Cell adhesion is a basic requirement for anchorage-dependent cells to survive on the matrix. It is the first step in a series of cell activities, such as cell diffusion, migration, proliferation, and differentiation. In vivo, cells are surrounded by extracellular matrix (ECM), whose physical and biochemical properties and micromorphology may affect and regulate the function and behavior of cells, causing cell reactions. Cell adhesion is also the basis of communication between cells and the external environment and plays an important role in tissue development. Therefore, the significance of studying cell adhesion in vitro has become increasingly prominent. For instance, in the field of tissue engineering and regenerative medicine, researchers have used artificial surfaces of different materials to simulate the properties of natural ECM, aiming to regulate the behavior of cell adhesion. Understanding the factors that affect cell behavior and how to control cell behavior, including cell adhesion, orientation, migration, and differentiation on artificial surfaces, is essential for materials and life sciences, such as advanced biomedical engineering and tissue engineering. This article reviews various factors affecting cell adhesion as well as the methods and materials often used in investigating cell adhesion.

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Section: Polymer Thin Filmsmentioning

confidence: 99%

Recent advance in surface modification for regulating cell adhesion and behaviors

Cai

Yang

et al. 2020

Nanotechnology Reviews

423

247

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“…Thin films can be coated on a variety of surfaces depends on their physicochemical properties such as wettability, reactivity, conductivity, and corrosion resistance. Thin films are currently being used in the fields of tissue engineering and biomedical industries for osseointegration in dental and orthopedic implants, biodegradable/biobased scaffolds, and biomimetic materials [29]. In this context, Mallakpour and Hatami [30] prepared chitosan nanocomposite films containing folic acid to utilize in tissue engineering as bone and teeth additives.…”

Section: Filmsmentioning

confidence: 99%

Retrospective, Perspective and Prospective of B-Complex Vitamins: Encapsulation of Vitamins and Release from Vitamin-Loaded Polymers

Parın¹

2022

B-Complex Vitamins - Sources, Intakes and Novel Applications

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Vitamins are regarded as vital nutrients because, when combined, they performed hundreds of functions in the body. They strengthen bones, heal wounds, and boost your immune system. In addition, they transform food into energy and heal cellular damage. In this regard, B-complex vitamins, such as thiamine, riboflavin, and niacin are soluble vitamins that serve as coenzymes in energy metabolism enzymatic activities which building blocks of a healthy body. However, B-complex vitamins are sensitive to light, pH conditions, and temperature. Consequently, they must be encapsulated before they may be used in pharmaceuticals. Recently, it is mainly focused on reducing drug degradation or loss, increase drug bioavailability, limit adverse effects, and improve drug accumulation in the targeted location. To maintain optimum bioavailability during a defined term of therapy, the fraction of drug dosage released from a controlled release product must be significant enough to adjust for the quantity of active drug metabolized and/or eliminated from the body over the same period. Drug release systems also aim to increase the effectiveness of the drug and treat the damaged area. In this chapter, it is aimed to study the production of the vitamin-loaded polymer systems in various forms, such as micro/nanoparticles, micelle, hydrogel, liposome, and nanofiber, as well as release studies in pharmaceutical and biomedical applications.

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“…Magnesium alloys have shown great potential for applications in bone tissue repair. They possess remarkable physical and mechanical properties such as an elastic modulus to that of a human bone (Griesser, 2016). For this research, the bio-degradable materials such as Iron and Magnesium alloy are used (Sangeetha et al, 2018); (Divya et al, 2019).…”

Section: S No Bottom Tip Diameter Circumcircle Diameter At Topmentioning

confidence: 99%

Application of Domain Integrated Design Methodology for Bio-Inspired Design- A Case Study of Suture Pin Design

et al. 2021

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This paper investigates the design and development of bio-inspired suture pins that would reduce the insertion force and thereby reducing the pain in the patients. Inspired by kingfisher's beak and porcupine quills, the conceptual design of the suture pin is developed by using a unique ideation methodology that is proposed in this research. The methodology is named as Domain Integrated Design, which involves in classifying bio-inspired structures into various domains. There is little work done on such bio-inspired multifunctional aspect. In this research we have categorized the vast biological functionalities into domains namely, cellular structures, shapes, cross-sections, and surfaces. Multi-functional bio-inspired structures are designed by combining different domains. In this research, the hypothesis is verified by simulating the total deformation of tissue and the needle at the moment of puncture. The results show that the bio-inspired suture pin has a low deformation on the tissue at higher velocities at the puncture point and low deformation in its own structure when an axial force (reaction force) is applied to its tip. This makes the design stiff and thus require less force of insertion.

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Thin films for tissue engineering applications

Cited by 19 publications

References 111 publications

Recent advance in surface modification for regulating cell adhesion and behaviors

Recent advance in surface modification for regulating cell adhesion and behaviors

Retrospective, Perspective and Prospective of B-Complex Vitamins: Encapsulation of Vitamins and Release from Vitamin-Loaded Polymers

Application of Domain Integrated Design Methodology for Bio-Inspired Design- A Case Study of Suture Pin Design

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