Thin Layer Chromatographic Analysis of Beta-Lactam Antibiotics

Hancu, Gabriel; Simon, Brigitta; Kelemen, Hajnal; Rusu, Aura; Mircia, Eleonora; Gyéresi, Árpád

doi:10.5681/apb.2013.059

Cited by 9 publications

(2 citation statements)

References 5 publications

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“…TLC can successfully be used for preliminary screening of the pharmaceutical compounds. It is commonly employed in contemporary analysis as a separation method to determine the presence or absence of antibiotics over a predetermined concentration level [ 38 , 39 ]. It can also be used to evaluate and categorize pure and impure antibiotic preparations as well as assay antibiotics quantitatively in bulk or pharmaceutical preparations [ 40 , 41 ].…”

Section: Methods Used To Analyze Antibioticsmentioning

confidence: 99%

A Review of Methods for Removal of Ceftriaxone from Wastewater

Karungamye

Rugaika

Mtei

et al. 2022

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The presence of pharmaceuticals in surface water and wastewater poses a threat to public health and has significant effects on the ecosystem. Since most wastewater treatment plants are ineffective at removing molecules efficiently, some pharmaceuticals enter aquatic ecosystems, thus creating issues such as antibiotic resistance and toxicity. This review summarizes the methods used for the removal of ceftriaxone antibiotics from aquatic environments. Ceftriaxone is one of the most commonly prescribed antibiotics in many countries, including Tanzania. Ceftriaxone has been reported to be less or not degraded in traditional wastewater treatment of domestic sewage. This has piqued the interest of researchers in the monitoring and removal of ceftriaxone from wastewater. Its removal from aqueous systems has been studied using a variety of methods which include physical, biological, and chemical processes. As a result, information about ceftriaxone has been gathered from many sources with the searched themes being ceftriaxone in wastewater, ceftriaxone analysis, and ceftriaxone removal or degradation. The methods studied have been highlighted and the opportunities for future research have been described.

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Section: Methods Used To Analyze Antibioticsmentioning

confidence: 99%

A Review of Methods for Removal of Ceftriaxone from Wastewater

Karungamye

Rugaika

Mtei

et al. 2022

JoX

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“…There are many and various analytical methods previously reported for assay of co-clavimox tablets which includes thin layer chromatography (TLC) [19][20][21][22], ultraviolet (UV) spectrophotometry [23,24], titration [25], high-performance liquid chromatography (HPLC) [26][27][28][29], capillary electrophoresis (CE) [30], and infrared spectroscopy (IR) [31], in both British Pharmacopoeia (B. P) and United States Pharmacopoeia (U. S. P). Among then, HPLC is recommended for the analysis of co-clavimoxin pure forms and pharmaceutical preparations.…”

Section: Fig 2: Structure Of Potassium Clavulanatementioning

confidence: 99%

Quality of Amoxicillin Trihydrate/Potassium Clavulanate Tablets Commercially Available in Libyan Pharmaceutical Market

EL-HDDAD,

SULIMAN

2023

Int J App Pharm

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Objective: The objective of this study was to compare the quality of the amoxicillin trihydrate/potassium clavulantae (co-clavimox) tablets those are locally available in Libyan pharmaceutical market manufactured by various pharmaceutical companies with United State Pharmacopeia (USP) standards. Methods: The five popular brands (clavomid, augmentin, clavodar, clamoxin, and clavimox) of co-clavimox conventional tablet of 625 mg strength were chosen. The quality of commercial products was evaluated through the identification of the content of active pharmaceutical ingredients (APIs) using UV- Spectrophotometer. Results: The results obtained showed that, the products clavomid, augmentin, and clavodar conformed to the USP standard limit for quantitative assay of active ingredients. Clamoxin passed the standard limit test with a slight deviation (<2%), while clavimox failed the test with values far below the acceptable range. Conclusion: This study has been able to confirm that some generic brands of co-clavimox tablets available in the Libyan markets possess qualities below official recommendations. Therefore, there is an urgent need for constant monitoring of different brands of medications in the market to ensure their safety and quality.

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An eco‐friendly multi‐analyte high‐performance thin layer chromatographic densitometric determination of amoxicillin, metronidazole, and famotidine in their ternary mixtures and simulated gastric juice: A promising protocol for eradicating Helicobacter pylori

Ragab

Maher

Tarek

et al. 2022

J of Separation Science

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Gastrointestinal tract disorders constitute a heavy burden to healthcare providers. To eradicate Helicobacter pylori infection, different triple therapy protocols have been proposed. Among which are combinations of proton pump inhibitors (e.g., omeprazole), histamine‐2 receptor antagonists (e.g., famotidine), along with antibiotics (e.g., amoxicillin). In this work, a sensitive and accurate high‐performance thin‐layer chromatographic method was developed for the simultaneous determination of amoxicillin, metronidazole, and famotidine in bulk powder and laboratory‐prepared combined‐tablet mixtures. Complete separation of the cited compounds was achieved using pre‐coated silica gel plates with a mixture of methanol:chloroform:toluene:water:glacial acetic acid (5:2:1.5:0.5:0.1 v/v/v/v/v) as the mobile phase. The method was fully validated as per the international conference of harmonization guidelines. Good linearity, a correlation coefficient of 0.9991, was obtained in the concentration ranges 0.1–1.6 μg/band (amoxicillin), 0.1–0.9 μg/band (metronidazole), and 0.1–0.9 μg/band (famotidine). Since the method allowed the determination of the three compounds in combined tablets with a high degree of selectivity, accuracy, precision, with cost‐effectiveness, it could be used for regular quality control. Moreover, the applicability of the proposed method was extended to the determination of the ternary mixture in simulated gastric juice. Method greenness was assessed using different green metrics.

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Thin Layer Chromatographic Analysis of Beta-Lactam Antibiotics

Cited by 9 publications

References 5 publications

A Review of Methods for Removal of Ceftriaxone from Wastewater

A Review of Methods for Removal of Ceftriaxone from Wastewater

Quality of Amoxicillin Trihydrate/Potassium Clavulanate Tablets Commercially Available in Libyan Pharmaceutical Market

An eco‐friendly multi‐analyte high‐performance thin layer chromatographic densitometric determination of amoxicillin, metronidazole, and famotidine in their ternary mixtures and simulated gastric juice: A promising protocol for eradicating Helicobacter pylori

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