Thin-layer reversed-phase ion-pair chromatography of some sulphonamides

Bieganowska, M. L.; Petruczynik, Anna; Doraczynska-Szopa, A.

doi:10.1016/0731-7085(93)80203-d

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…Because of their nonpolar character, the ion pair formed can interact in a selective way with reversed phases. Applications for ion-pair chromatography in re versed-phase thin-layer chromatography include the separation of antibiotics (132), antihistamines (133), antiarrhythmics (134), and pharmaceuticals (135,136).…”

Section: Hydrophobic Modified Phases (Rp Phases)mentioning

confidence: 99%

Sorbents and Precoated Layers in Thin-Layer Chromatography

Rabel¹

2003

Handbook of Thin-Layer Chromatography

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Section: Hydrophobic Modified Phases (Rp Phases)mentioning

confidence: 99%

Sorbents and Precoated Layers in Thin-Layer Chromatography

Rabel¹

2003

Handbook of Thin-Layer Chromatography

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“…Bieganowska sa saradnicima [32] iz dobijenih parametara 0 M R i m izračunava parametar hidrofobnosti C 0 , slično ranije definisanom ϕ o parametru:…”

Section: Hromatografske Metodeunclassified

“…Parametar C 0 definisan je kao udeo organske komponente u mobilnoj fazi (% v/v) za koji je R M = 0 [32].…”

Section: Hromatografske Metodeunclassified

“…Bieganovska i saradnici [32] ispitivali su mogućnost primene normalno-fazne TLC metode za sistematsko proučavanje hidrofobnosti sulfonamida. Ispitivanja u uslovima NP-TLC su vršena na silika-gelu, poliamidu i florisilu primenom dvokomponentnih mobilnih faza (dihlormetan-acetonitril, dihlormetan-etanol, dihlormetan-metil-etil-keton, dihlormetan-tetrahidrofuran, dihlormetan-dioksan) uz promenu odnosa komponenata.…”

Section: Hromatografske Metodeunclassified

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Chromatography methods in investigation of lipophilicity of the biological active substances

Odović

Trbojević-Stanković

2009

Hem Ind

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This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role

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“…Another approach is based on the explanation that the surface tension of the mobile phase changes with its composition, thereby altering the energy of vacancy formation required for the accommodation of solute molecules. 2 Besides the lipophilicity parameter R M 0 , the parameter C 0 , defined as the ratio of the intercept and slope values, is frequently used in this type of investigations: 4 C 0 = −R M 0 /b (2) C 0 could be understood as the concentration of an organic modifier in the mobile phase for which the distribution of the solute between the two phases is equal, i.e., R M = 0, R F = 0.5. It could also be interpreted as the hydrophobicity per unit of specific hydrophobic surface area.…”

Section: Introductionmentioning

confidence: 99%

Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters

Rabtti

Natić

Milojković‐Opsenica

et al. 2012

JSCS

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Four lipophilicity descriptors (RM0, b, C0, PC1) for twelve coumarine derivatives were determined by reversed-phase thin-layer chromatography in order to analyze which descriptor best describes the lipophilicity of coumarines investigated. Moreover, possible chemical toxicity of coumarins, expressed as the probability of a compound to cause organ-specific health effects, was calculated using ACD/Tox Suite program. The quantitative relationships between toxicity and molecular descriptors, including experimentally determined lipophilicity descriptors obtained in current study, were investigated using partial least square regression. The best models were obtained for kidney and liver health effects. Quantitative structure-toxicity relationship models revealed the importance of electric polarization descriptors, size descriptors and lipophilicity descriptors. Obtained models were used for the selection of the structural features of the compounds that are significantly affecting their absorption, distribution, metabolism, excretion, and toxicity. [Acknowledgements. This work has been supported by the Ministry of Education and Science of Serbia, Grant 172017.

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Thin-layer reversed-phase ion-pair chromatography of some sulphonamides

Cited by 9 publications

References 23 publications

Sorbents and Precoated Layers in Thin-Layer Chromatography

Sorbents and Precoated Layers in Thin-Layer Chromatography

Chromatography methods in investigation of lipophilicity of the biological active substances

Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters

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