Things We Do for No Reason™: Routine use of proton pump inhibitors for peptic ulcer prophylaxis in adults on high‐dose corticosteroids

Kumar, Sriram S; Arvind, Shreya; Umpierrez, Adrian

doi:10.1002/jhm.13095

Cited by 5 publications

(1 citation statement)

References 14 publications

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“… 21 Proton pump inhibitors are commonly prescribed with corticosteroids, although the evidence supporting this is limited. 22 Cost, availability, and rapid onset of action make corticosteroids an appealing initial choice. Potential side effects include increased susceptibility to infection, worsening glycemic control, blood pressure elevation, and psychological symptoms (anxiety, mania, and low mood).…”

Section: Acute Istmentioning

confidence: 99%

Review of the Longitudinal Management of Autoimmune Encephalitis, Potential Biomarkers, and Novel Therapeutics

Mahadeen,

Carlson,

Cohen

et al. 2024

Neur Clin Pract

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Purpose of Review Increasing awareness and earlier diagnosis of autoimmune encephalitis (AE) have led to a greater number of patients being cared for longitudinally by neurologists. Although many neurologists are now familiar with the general approach to diagnosis and acute immunosuppression, this review aims to provide neurologists with guidance related to management beyond the acute phase of disease, including long-term immunosuppression, monitoring, potential biomarkers of disease activity, outcome measures, and symptom management. Recent Findings Observational studies in AE have demonstrated that early diagnosis and treatment is associated with improved neurologic outcomes, particularly in AE with antibodies targeting neuronal cell surface/synaptic proteins. The literature regarding long-term management is evolving. In addition to traditional immunosuppressive approaches, there is emerging use of novel immunosuppressive therapies (ISTs) in case series, and several randomized controlled trials are planned. Novel biomarkers of disease activity and methods to measure outcomes and response to treatment are being explored. Furthermore, it is increasingly recognized that many individuals have chronic symptoms affecting quality of life including seizures, cognitive impairment, fatigue, sleep disorders, and mood disorders, and there are emerging data supporting the use of patient centered outcome measures and multidisciplinary symptom-based care. Summary This review aims to summarize recent literature and offer a practical approach to long-term management of adult patients with AE through a multidisciplinary approach. We summarize current knowledge on ISTs, potential biomarkers of disease activity, outcome measures, and long-term sequelae. Further research is needed to answer questions regarding optimal IST, biomarker validity, and sequelae of disease.

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Section: Acute Istmentioning

confidence: 99%