Thio Analogues of Pyrimidine Bases: Syntheses and Spectral Study of New Potentially Biologically Active 2,4-Di-Ortho-(Meta- and Para-)Bromo- (Chloro and Nitro)-Benzylthio-5-Bromouracils (and 6-Methyluracils)

Synthesis and Cytotoxicity of Arene‐Ru Compounds Containing 4‐Nitroaniline or 2‐Halogenated 4‐Nitroaniline

“…The introduction of halogen atoms into the lead molecule is a well known strategy in developing new bioactive agent . For example, 5‐fluorouracil is anticancer medicine in the treatment of malignant tumors, particularly colorectal carcinoma,, whereas 5‐bromouracil and 5‐iodouracil show totally different bioacitivities, and have recently been considered promising structures for developing new antiviral agents , …”

Sulfur Analogs of Pyrimidine Bases: Synthesis of 2‐Alkylthio‐ and 4‐Alkylthio‐5‐bromouracils and In Silico Evaluation of Their Biological Activity

“…In continuation of our works on bromothiouracil derivatives and in search for novel biologically active compounds, we have performed a series of bromination reactions of alkyl derivatives of 2‐thiouracil ( I , II , III , IV , IX ), 2‐thio‐6‐methyluracil ( V , VI , VII , VIII , X ), 2‐thioorotic acid ( XI , XII , XIII , XIV , XIX ), 4‐thiouracil ( XV , XVI , XVII , XVIII , XX ), and 4‐thio‐6‐methyluracil ( XXI , XXII , XXIII , XXV , XXVI ). To ensure good cell barrier permeability in order to improve pharmacokinetic properties of brominated thiouracils, the sulfur atoms in the substrates chosen have been substituted by long alkyl chains containing 10–18 carbon atoms, that is, n ‐decyl, n ‐dodecyl, n ‐tetradecyl, n ‐hexadecyl, and n ‐octadecyl.…”

Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils

“…This fact has stimulated us to investigate the reaction of chlorobenzylation of 2-thio-5-piperidinomethyl-6-methylthiouracil and 2-thio-5-morpholinomethyl-6-methylthiouracil as well as the Mannich reaction of 2- o -( m - and p -)chlorobenzylthio-6-methylthiouracils, formaldehyde, and piperidine (or morpholine). Recently novel pharmacological action of 2,4-di- o -( m - and p -)bromo-(chloro- and nitro-)benzylthio-5-bromouracils (and 6-methyluracils) [10] as well as disulfides of N , O -( N , N - or O , O -)-di- and N , N , O -tri-( o -, m - and p -)-bromobenzyl-2-thiouracils [11] has been found on the basis of the computer-aided drug discovery approach with the compounds program Prediction of Activity Spectra for Substances (PASS) [12–15]. Since only the structural formula of the chemical compound is necessary to obtain a PASS prediction, this approach was used in the present work.…”