Thioacetamide Induced in Albino Wistar Rats: Importance of Coleus aromaticus Aqueous Leaf Extract for Hepatoprotective Activity

Abstract

This study was conducted to hepatoprotective effects of Coleus aromaticus aqueous leaf extract (C. aromaticus-ALE) of on Thioacetamide and Silymarin induced liver poisonousness in wistar rats. Phytochemical screenings of C. aromaticus-ALE were used to find out the preliminary constituents. Adult male wistar rats (weight range: 200-220g) were divided into 6 groups (n= 6). Thioacetamide and Silymarin stayed managed intraperitoneally arranged the 5th day to rats in all groups but the normal control. Phytochemical screen of C. aromaticus-ALE contains flavonoids, saponins, tannins, phenol, tri-terpenoids, carbohydrate, anthraquinones, and phytosteroids. The biochemical markers of hepatic damage like AST, ALT, APT, Bilirubin and cholesterol. Furthermore, a significant hepatoprotective of the aqueous extract leaf and oral dose of Thioacetamide and Silymarin. C. aromaticus-ALE did not mortality or significant changes in the body weight. Process of hepatotoxicity induced by Thioacetamide in rats was interceded by control and these effects were comparable to those administered with Silymarin. This is the first report on hepatoprotective effect of C. aromaticus-ALE against Thioacetamide-induced hepatotoxicity. 
 Keywords: Thioacetamide, Silymarin, Coleus aromaticus, biochemical-hematological parameters, aqueous leaf extract.