2006
DOI: 10.1007/s11373-005-9055-5
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Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis

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Cited by 80 publications
(57 citation statements)
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“…The existence of caspase-10 in fish was demonstrated in this study. In addition, caspase-8 has been cloned from medaka and zebrafish [23,30]. While fish diverged from amphibians 350 million years ago and they have established the characteristic immune system to adapt to their living environment, both caspase-8 and caspase-10 have been maintained in fish as well as mammals.…”
Section: Discussionmentioning
confidence: 99%
“…The existence of caspase-10 in fish was demonstrated in this study. In addition, caspase-8 has been cloned from medaka and zebrafish [23,30]. While fish diverged from amphibians 350 million years ago and they have established the characteristic immune system to adapt to their living environment, both caspase-8 and caspase-10 have been maintained in fish as well as mammals.…”
Section: Discussionmentioning
confidence: 99%
“…The frozen livers were cryosectioned, and the sections were subjected to hematoxylin and eosin staining. The frozen sections were also stained with Oil Red O to visualize the fat deposits in the liver, as described previously (2). The stained sections were visualized under a light field, and images were captured at different magnifications.…”
Section: Methodsmentioning
confidence: 99%
“…The zebrafish field abounds with models of human diseases, with zebrafish carrying a mutation in a specific disease gene manifesting phenotypes strikingly similar to those observed in humans. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Zebrafish models of human diseases include cardiovascular diseases (reviewed in Ref. 29), Duchenne muscular dystrophy, 30 various cancers (reviewed in Ref.…”
Section: Zebrafish As Models Of Human Physiology and Diseasementioning
confidence: 99%