Thiobarbiturate-induced Histamine Release in Human Skin Mast Cells

Hirshman, Carol A.; Edelstein, Robert A.; Ebertz, J. Mark; Hanifin, Jon M.

doi:10.1097/00000542-198510000-00002

Cited by 51 publications

(16 citation statements)

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“…121,124 Most of the adverse reactions with barbiturates, particularly thiopental, are caused by specific-IgE antibody, although direct histamine-releasing activity also occurs. 121,[135][136][137] The importance of immunologic cross-reactivity is unknown. Skin testing may be clinically useful, but the concentration of drug testing must be less than the concentration that result in irritation.…”

Section: Anaphylaxis During Generalmentioning

confidence: 99%

The diagnosis and management of anaphylaxis practice parameter: 2010 Update

Lieberman

Nicklas

Oppenheimer

et al. 2010

Journal of Allergy and Clinical Immunology

666

818

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These parameters were developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the American College of Allergy, Asthma & Immunology (ACAAI); and the Joint Council of Allergy, Asthma and Immunology. The AAAAI and the ACAAI have jointly accepted responsibility for establishing "The Diagnosis and Management of Anaphylaxis Practice Parameter: 2010 Update." This is a complete and comprehensive document at the current time. The medical environment is a changing environment, and not all recommendations will be appropriate for all patients. Because this document incorporated the efforts of many participants, no single individual, including those who served on the Joint Task Force, is authorized to provide an official AAAAI or ACAAI interpretation of these practice parameters. Any request for information about or an interpretation of these practice parameters by the AAAAI or ACAAI should be directed to the Executive Offices of the AAAAI, the ACAAI, or the Joint Council of Allergy, Asthma and Immunology. These parameters are not designed for use by pharmaceutical companies in drug promotion.

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Section: Anaphylaxis During Generalmentioning

confidence: 99%

The diagnosis and management of anaphylaxis practice parameter: 2010 Update

Lieberman

Nicklas

Oppenheimer

et al. 2010

Journal of Allergy and Clinical Immunology

666

818

View full text Add to dashboard Cite

show abstract

“…The exact mechanisms by which RBF stays constant during thiamylal administration remains unclear. Thiamylal evokes histamine release which in turn induces vasodilation [21]. These findings could explain the protective effects of thiamylal on RBF.…”

Section: Discussionmentioning

confidence: 94%

Effects of the Intravenously Administered Anaesthetics Ketamine, Propofol, and Thiamylal on the Cortical Renal Blood Flow in Rats

Shiga

Minami²,

Uezono³

et al. 2003

Pharmacology

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Intravenous anaesthetics such as ketamine, propofol, and thiamylal are widely used, although the direct effects of these anaesthetics on the renal blood flow (RBF) have not been well elucidated. In this study, we examined the effects of bolus and continuous administrations of ketamine, propofol, and thiamylal on cortical RBF and the effects of noradrenaline (NA) on RBF under continuous administration of these anaesthetics. We used laser Doppler flowmetry to measure the effects of bolus injection and continuous infusion of ketamine, propofol, and thiamylal on cortical RBF in male Wistar rats. We also examined the effects of the anaesthetics on mean arterial blood pressure (MAP) and heart rate (HR). Bolus injections of ketamine, propofol, or thiamylal (1–8 mg/kg each, n = 10) at clinically relevant concentrations did not affect MAP, HR, or RBF. Continuous administration of ketamine, propofol, or thiamylal (1–8 mg/kg/h each, n = 10) did not affect MAP, HR or RBF. Exogenous NA (2 µg/kg) caused an increase in MAP and a decrease in RBF and HR. In experiments with continuous infusions of propofol or thiamylal (1–8 mg/kg/h each, n = 10), similar results were observed without infusion of any anaesthetics. However, bolus injection of NA did not result in a decrease in RBF during continuous ketamine infusion (98.8 ± 6.7% of control, n = 6, p < 0.05), while ketamine did not affect the NA-induced increase in MAP. In conclusion, bolus and continuous administrations of ketamine, propofol, and thiamylal did not affect the RBF. From our present findings, ketamine would be useful for maintaining the RBF.

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“…Thiopental, a short-acting barbiturate, was among the first drugs used in anesthesia reported to cause adverse reactions [62]. Both immunological [6,30] and non-immunological mechanisms [33,61] are involved in thiopental-induced basophil and mast cell activation. Pro pofol, even in the reformulated preparation, has been shown to induce skin flushing and a transient increase in plasma histamine [60], whereas ketamine has rarely been indicated as a cause of adverse reactions [63],…”

Section: General Anestheticsmentioning

confidence: 99%

Role of Mast Cells, Basophils and Their Mediators in Adverse Reactions to General Anesthetics and Radiocontrast Media

Genovese

Stellato

Marsella

et al. 1996

Int Arch Allergy Immunol

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General anesthetics and radiocontrast media (RCM) can cause anaphylactic or anaphylactoid reactions. These are usually underdiagnosed and underreported, but their incidence is apparently rising. Their pathogenesis is complex and not completely understood, but the release of vasoactive mediators from basophils and mast cells plays a central role. The recent development of in vitro techniques to study the release of preformed (histamine and tryptase) and de novo synthesized mediators (PGD₂, LTC₄, and PAF) from purified basophils and mast cells has made it possible to quantify the mediator-releasing activity of anesthetics such as muscle relaxants, general anesthetics, opioids, and benzodiazepines and RCM on human basophils and mast cells isolated from lung, skin and heart tissues. The majority of general anesthetics and RCM tested induced only the release of preformed mediators (histamine and tryptase), not of the de novo synthesized eicosanoids. There was wide variability in the response of basophils and mast cells from different donors to the same drug or RCM, presumably due to the releasability parameter. Hyperosmolality is probably not the only factor responsible for basophil and mast cell activation by RCM. The in vitro release of histamine induced by anesthetic drugs and RCM was correlated with the release of tryptase. Given the longer half-life of tryptase than histamine in plasma, measurements of plasma tryptase may become a useful diagnostic tool for identifying adverse reactions to anesthetics and RCM.

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Thiobarbiturate-induced Histamine Release in Human Skin Mast Cells

Cited by 51 publications

References 0 publications

The diagnosis and management of anaphylaxis practice parameter: 2010 Update

The diagnosis and management of anaphylaxis practice parameter: 2010 Update

Effects of the Intravenously Administered Anaesthetics Ketamine, Propofol, and Thiamylal on the Cortical Renal Blood Flow in Rats

Role of Mast Cells, Basophils and Their Mediators in Adverse Reactions to General Anesthetics and Radiocontrast Media

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