Thiol-Dependent Peroxidases in Mycobacterium tuberculosis Antioxidant Defense

Hugo, Martín; Radí, Rafael; Trujillo, Madia

doi:10.5772/32330

Cited by 1 publication

(2 citation statements)

References 148 publications

(156 reference statements)

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“…S-Mycothiolation affected CgTPx activity that was restored by incubation with CgMrx1 (17). MSH/Mrx1-dependent reduction has not been described in other Prxs from Mycobacteria (TPx and AhpC) studied so far, where NADPH/thioredoxin reductase is directly used to reduce different isoforms of thioredoxin, the reducing substrates for most of the bacterial Prxs (13,18). For MtAhpC, an alternative reducing system, based on dihydrolipoamide linked to metabolic enzymes, has been demonstrated (42).…”

Section: Discussionmentioning

confidence: 99%

“…So far no MtMrx1-dependent protein reduction has been described in Mycobacteria. M. tuberculosis expresses a heme-dependent peroxidase (catalase peroxidase, KatG, EC 1.11.1.6) and several thiol-dependent peroxidases of the peroxiredoxin (Prx, EC 1.11.1.15) type, including alkyl hydroperoxide reductase C, TPx, two bacterioferritin comigratory proteins (Bcp andBcpB) and alkyl hydroperoxide reductase E (MtAhpE) (13,18). 7 As a one-cysteine peroxidase, MtAhpE lacks a resolving cysteine.…”

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confidence: 99%

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Mycothiol/Mycoredoxin 1-dependent Reduction of the Peroxiredoxin AhpE from Mycobacterium tuberculosis

Hugo

Laer

Reyes

et al. 2014

Journal of Biological Chemistry

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Background: Mycothiol, the major low-molecular weight thiol of Mycobacterium tuberculosis, is important for peroxide detoxification and virulence. Results: Mycothiol, together with mycoredoxin-1, a glutaredoxin-like protein, reduces the one-cysteine peroxiredoxin AhpE from the bacterium. Conclusion: Mycobacterium tuberculosis AhpE is a mycothiol/mycoredoxin-1-dependent peroxidase. Significance: Our results provide the first molecular link between a thiol-dependent peroxidase and the mycothiol/mycoredoxin-1 pathway in Mycobacteria.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%