Thiol/disulfide homeostasis as a novel indicator of oxidative stress in obstructive sleep apnea patients

Dinç, Mehmet Emre; Özdemir, Cengiz; Ayan, Nilhan Nurlu; Bozan, Nazım; Ulusoy, Seçkin; Koca, Cemile; Erel, Özcan

doi:10.1002/lary.26444

Cited by 18 publications

(10 citation statements)

References 22 publications

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“…They can be reduced and oxidised by dynamic thiol/disulphide homeostasis in the case of oxidative stress. There is an increasing body of evidence for the presence of abnormal thiol/disulphide homeostasis in the pathogenesis of diseases such as diabetes mellitus [14], cardiovascular diseases [10,11], cancer [15], rheumatoid arthritis [16], chronic kidney disease [17], obstructive sleep apnoea [18], and Parkinson's disease [19]. In the present study, we also demonstrated that oxidative stress levels are higher in patients with NSTE-ACS using dynamic thiol/disulphide parameters.…”

Section: Discussionsupporting

confidence: 69%

Dynamic thiol/disulphide homeostasis and its prognostic value in patients with non-ST elevation-acute coronary syndromes

Sivri¹,

Kasapkara

Polat

et al. 2018

Kardiol Pol

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Section: Discussionsupporting

confidence: 69%

Dynamic thiol/disulphide homeostasis and its prognostic value in patients with non-ST elevation-acute coronary syndromes

Sivri¹,

Kasapkara

Polat

et al. 2018

Kardiol Pol

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“…Beyond schizophrenia, other putative metabolite-phenotype associations from this analysis appeared to be feasible as well: cysteinylglycine disulfide (associated with sleep duration) is a disulfide, and disulfides have been explored as a marker of stress in obstructive sleep apnea 64 , and glutaroylcarnitine (associated with cognitive performance) levels are known to be altered in glutaric acidemia type 1, which can manifest in neurological problems like dystonia 65 . Among the novel findings, N-delta-acetylornithine (associated with schizophrenia) was also associated with cognition and alcoholism.…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations

Panyard

Kim

Darst

et al. 2020

Preprint

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Advances in technology have allowed for the study of metabolomics in the context of disease, enabling the discovery of new potential risk factors, diagnostic markers, and drug targets. For neurological and psychiatric phenotypes, the cerebrospinal fluid (CSF) is of particular biomedical importance as it is in direct contact with the brain and spinal cord. However, the CSF metabolome is difficult to study on a large scale due to the relative complexity of the procedure needed to collect the fluid compared to blood or urine studies. Here, we present a metabolome-wide association study (MWAS), an analysis using individual-level genetic and metabolomic data from two cohorts to impute metabolites into large samples with genome-wide association summary statistics. We conducted a metabolome-wide genome-wide association analysis with 338 CSF metabolites, identifying 16 genotype-metabolite associations, 6 of which were novel. Using these results, we then built prediction models for all available CSF metabolites and tested for associations with 27 neurological and psychiatric phenotypes in large cohorts, identifying 19 significant CSF metabolite-phenotype associations. Our results demonstrate the potential of MWAS to overcome the logistic challenges inherent in cerebrospinal fluid research to study the role of metabolomics in brain-related phenotypes and the feasibility of this framework for similar studies of omic data in scarce sample types.

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“…Authors have demonstrated that NT levels were significantly lower in patients with benign paroxysmal positional vertigo, seasonal allergic rhinitis, Bell's palsy, obstructive sleep apne and nasal polyposis [53][54][55][56][57].…”

Section: Head and Neck Pathologiesmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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Thiol/disulfide homeostasis as a novel indicator of oxidative stress in obstructive sleep apnea patients

Abstract: 3b. Laryngoscope, 127:E244-E250, 2017.

Cited by 18 publications

References 22 publications

Dynamic thiol/disulphide homeostasis and its prognostic value in patients with non-ST elevation-acute coronary syndromes

Dynamic thiol/disulphide homeostasis and its prognostic value in patients with non-ST elevation-acute coronary syndromes

Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

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