Thiol-Disulfide Homeostasis as an Oxidative Stress Indicator

Yazar, Hayrullah; Kayacan, Yıldırım; Erel, Özcan

doi:10.1007/978-3-030-81304-8_47-1

Cited by 1 publication

(3 citation statements)

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“…Biological aspects of sulfur-containing antioxidant actions, their metabolism, and implementation in diseases pathogenesis are discussed in detail in reviews [ 10 , 16 , 19 , 22 , 24 , 25 , 30 , 31 , 32 ].…”

Section: Sulfur-containing Antioxidants and Their Action In Living Sy...mentioning

confidence: 99%

“…The presence of H-atom in the thiol group provides its reaction with free radicals via H-atom transfer or oxidation to disulfide in reactions with oxidants. The so-called thiol–disulfide equilibrium is formed in living systems ( Scheme 1 ) and is used as one of the oxidative stress indicators [ 9 , 10 ]. The equilibrium is dynamic and its shift is meaningful for the evaluation of the organism redox status [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…The so-called thiol–disulfide equilibrium is formed in living systems ( Scheme 1 ) and is used as one of the oxidative stress indicators [ 9 , 10 ]. The equilibrium is dynamic and its shift is meaningful for the evaluation of the organism redox status [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Electrochemical Sensors for Sulfur-Containing Antioxidants

Ziyatdinova

Gimadutdinova

2023

Micromachines

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Sulfur-containing antioxidants are an important part of the antioxidant defense systems in living organisms under the frame of a thiol–disulfide equilibrium. Among them, l-cysteine, l-homocysteine, l-methionine, glutathione, and α-lipoic acid are the most typical representatives. Their actions in living systems are briefly discussed. Being electroactive, sulfur-containing antioxidants are interesting analytes to be determined using various types of electrochemical sensors. Attention is paid to the chemically modified electrodes with various nanostructured coverages. The analytical capabilities of electrochemical sensors for sulfur-containing antioxidant quantification are summarized and discussed. The data are summarized and presented on the basis of the electrode surface modifier applied, i.e., carbon nanomaterials, metal and metal oxide nanoparticles (NPs) and nanostructures, organic mediators, polymeric coverage, and mixed modifiers. The combination of various types of nanomaterials provides a wider linear dynamic range, lower limits of detection, and higher selectivity in comparison to bare electrodes and sensors based on the one type of surface modifier. The perspective of the combination of chromatography with electrochemical detection providing the possibility for simultaneous determination of sulfur-containing antioxidants in a complex matrix has also been discussed.

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