Thiol disulfide homeostasis in psychiatric disorders: A comprehensive review

Tuncay, Merve Ergin; Atagün, Murat İlhan; Erel, Özcan

doi:10.1016/j.pnpbp.2023.110719

Cited by 8 publications

(4 citation statements)

References 166 publications

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“…Plasma -SH concentrations in (FE-)SDMD patients were not significantly reduced, contrary to expectations, despite TRAP inhibition. Previous studies have identified decreased thiol groups in patients with MDD or depressive symptoms (Beğinoğlu et al, 2023; Roomruangwong et al, 2017; Tuncay et al, 2023). Conversely, several studies have detected elevations in -SH groups in patients with depression and cognitive impairment, suggesting that increased O&NS levels resulted in increased plasma thiols (Gałecki et al, 2013; Karaaslan et al, 2018; Sundaram and Prabhu, 2021).…”

Section: Discussionmentioning

confidence: 99%

Increased malondialdehyde and nitric oxide formation, lowered total radical trapping capacity coupled with psychological stressors largely predict the phenome of first-episode mild depression in undergraduate students

Brinholi,

Vasupanrajit,

Semeão

et al. 2024

Preprint

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Undergraduate students are frequently afflicted by major depressive disorder (MDD). Oxidative and nitrosative stress (O&NS) has been implicated in the pathophysiology of MDD. There is no information regarding whether mild outpatient MDD (SDMD) and first episode SDMD (FE-SDMD) are accompanied by O&NS. The current study compared lipid hydroperoxides (LOOH), malondialdehyde (MDA), advanced protein oxidation products, nitric oxide metabolites (NOx), thiol groups, plasma total antioxidant potential (TRAP), and paraoxonase 1 activities among SDMD and FE-SDMD patients versus healthy controls. We found that SDMD and FE-SDMD exhibit elevated MDA and NOx, and decreased TRAP and LOOH as compared with controls. There was a significant and positive correlation between O&NS biomarkers and adverse childhood experiences (ACEs), and negative life events (NLEs). O&NS pathways, NLEs and ACEs accounted for 51.7% of the variance in the phenome of depression, and O&NS and NLS explained 42.9% of the variance in brooding. Overall, these results indicate that SDMD and FE-SDMD are characterized by reduced total antioxidant defenses and increased aldehyde and NOx production. The combined effects of oxidative and psychological stressors substantially predict the manifestation of SDMD. The differences with multi-episode MDD are attributed to specific effects of recurrence of illness and staging of illness.

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Section: Discussionmentioning

confidence: 99%

Increased malondialdehyde and nitric oxide formation, lowered total radical trapping capacity coupled with psychological stressors largely predict the phenome of first-episode mild depression in undergraduate students

Brinholi,

Vasupanrajit,

Semeão

et al. 2024

Preprint

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“…Thiol/disul de switches play critical roles in signal transduction, thiol protection, and redox homeostasis regulation [11]. This balance has been shown to be disrupted in cases such as acute myocardial infarction, hypertension, diabetes mellitus, Alzheimer's disease, diabetic nephropathy, schizophrenia, depression, acute pulmonary embolism, nonsmall cell lung cancer, celiac disease, acute pancreatitis, and in ammatory bowel disorder, as well as familial Mediterranean fever [40][41][42][43][44][45]. To date, many approaches have been used to quantify thiol levels in order to elucidate this defense function in the organism against oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Physical frailty is related to oxidative stress through thiol/disulfide homeostasis parameters

Hafızoğlu,

Eren,

Neşelioğlu

et al. 2024

Eur Geriatr Med

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To evaluate relationship between frailty and oxidative stress through thiol/disul de homeostasis parameters (Native thiol (NT), total thiol (TT), and disul de levels (D), disul de-native thiol (D/NT), disul de-total thiol (D/TT), native thiol-total thiol (NT/TT) ratios and ischemia-modi ed albumin levels (IMA)). Materials and MethodIn total, 139 community-dwelling older adults were included. The frailty status, de ned by the FRIED frailty index (FFI) and Clinical Frailty Scale (CFS), and comprehensive geriatric assessment results compared with thiol/disul de homeostasis parameters and ischemia-modi ed albumin levels. ResultsNT and TT levels were signi cantly lower in the frail group (respectively; p = 0.014, p = 0.020). The FFI scores were correlated with the levels of NT, TT, D/NT, D/TT, and NT/TT (respectively; r=-0.25, r=-0.24, r = 0.17, r = 0.17, r=-0.17). The signi cant correlation could not be retained with the CFS scores. In ROC analysis, the AUC for NT was calculated as 0.639 in diagnosing frailty according to the FFI (95% CI: 0.542-0.737), AUC was 0.638 for TT (95% CI: 0.540-0.735), AUC was 0.610 for NT/TT (95% CI: 0.511-0.780). The AUC was calculated as 0.610 for both D/NT and D/TT in diagnosing physical frailty (95% CI: 0.511-0.708). ConclusionThiol/disul de homeostasis parameters can be a potential biomarker in diagnosing physical frailty.However, further studies are needed for diagnosing frailty de ned with cumulative de cit models. Key pointsAim: To evaluate the relationship between frailty, and thiol/disul de homeostasis parameters, and ischemia-modi ed albumin levels.Findings: Native thiol, total thiol levels, and disul de-thiol ratios were associated with physical frailty. Message: Thiol/disul de homeostasis parameters can be used to identify physical frailty. Newly developed oxidative stress parameters are required to determine frailty, as indicated by both phenotype and cumulative models.

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“…Recent research has indicated that reactive oxygen radicals might contribute to the pathophysiology of depression by inducing neuronal damage due to an imbalance between oxidative and antioxidative systems. 15 - 16 , 17 The current research was devised to assess thiol/disulfide parameters in individuals with MDD, a condition where oxidative stress is understood to be a factor, and to determine if these molecules, measurable in clinical settings, could serve as a distinctive marker.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Thiol/Disulfide Interrelation in Major Depressive Disorder

Beğinoğlu,

Asoğlu,

Sabuncu

et al. 2024

ALPHA PSYCHIATRY

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Objective: Although major depressive disorder (MDD) constitutes a significant part of mental health problems, its pathogenesis has not been fully elucidated. The inadequacy of diagnostic tests specific to MDD causes difficulty in diagnosis. Therefore, we investigated the situation of thiol/disulfide imbalance, which may play a role in the pathogenesis of many diseases, in MDD patients. Methods: Forty-five MDD patients and 40 non-patient volunteers participated in our study. Sociodemographic data form, Beck Depression Scale, and Clinical Global Impression Scale were used in making the diagnosis and evaluation process. Results: There was a significant difference between the MDD and non-patient groups in native thiol and total thiol levels, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios. No significant difference was detected in terms of disulfide level between the 2 groups. There was no significant difference between the patients’ thiol disulfide ratios and the severity of depression. There was no significant difference between the patients’ symptom duration and thiol disulfide ratios. Nevertheless, a negative correlation was identified between the duration of the patients’ symptoms and their disulfide levels. Conclusion: When the results were examined in terms of thiol and disulfide ratios, they showed that thiol and disulfide ratios were impaired in depression. We think that thiol/disulfide parameters may be a biomarker candidate that can help in the diagnosis of MDD.

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Thiol disulfide homeostasis in psychiatric disorders: A comprehensive review

Cited by 8 publications

References 166 publications

Increased malondialdehyde and nitric oxide formation, lowered total radical trapping capacity coupled with psychological stressors largely predict the phenome of first-episode mild depression in undergraduate students

Increased malondialdehyde and nitric oxide formation, lowered total radical trapping capacity coupled with psychological stressors largely predict the phenome of first-episode mild depression in undergraduate students

Physical frailty is related to oxidative stress through thiol/disulfide homeostasis parameters

Evaluation of Thiol/Disulfide Interrelation in Major Depressive Disorder

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