Thiol/disulphide homeostasis in bipolar disorder

Erzın, Gamze; Kotan, Vahap Ozan; Topçuoğlu, Canan; Özkaya, Güven; Erel, Özcan; Yüksel, Rabia Nazik; Ürer, Emre; Aydemir, Makbule Çiğdem; Göka, Erol

doi:10.1016/j.psychres.2017.12.062

Cited by 19 publications

(19 citation statements)

References 44 publications

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“…In patients group, NT and TT levels were lower than remission and control group whereas no significant difference is detected between groups [47].…”

Section: Psychiatric Diseasesmentioning

confidence: 63%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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“…In patients group, NT and TT levels were lower than remission and control group whereas no significant difference is detected between groups [47].…”

Section: Psychiatric Diseasesmentioning

confidence: 63%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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“…Previously, we showed that the native thiol and total thiol levels were lower in patients with mania compared to those in remission and controls; and speculated that this might be related to malnutrition during manic episodes [18]. There were not any significant differences between the bipolar mania, remission and control groups in terms of their disulfide level in our previous study.…”

Section: Discussionmentioning

confidence: 53%

“…TDH as an antioxidant parameter has been previously investigated in a variety of clinical conditions, such as schizophrenia, bipolar disorder in manic episode and remission, major depressive disorder, general anxiety disorder [18,21,22,28,29]. To the best of our knowledge, this is the first study investigating dynamic TDH in bipolar disorder patients with depressive episodes.…”

Section: Discussionmentioning

confidence: 99%

“…Effect size from our previous study [ 18 ] between patient and control was 0.56 for disulfide/native thiol ratio. A power analysis revealed that in order for d = 0.56 effect size of disulfide/native thio to be detected (80% power) as significant at the 5% level, a sample of 50 participants would be required for patient and control group comparison.…”

Section: Methodsmentioning

confidence: 99%

“…Examining dynamic TDH can provide significant insight into diverse biochemical processes, either normal or abnormal [17]. In this regard, the abnormal state of TDH may affect the pathogenesis of several clinical conditions, such as schizophrenia, neurodegenerative disorders, and bipolar disorder [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression

Erzın

Özkaya

Topçuoğlu

et al. 2020

Clin Psychopharmacol Neurosci

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Objective: Bipolar disorder and unipolar depressive disorder are complex phenotypes. There appear to be phenotypical, mechanistic, and therapeutic differences between bipolar depression (BD) and unipolar depression (UD). There is a need for understanding the underlying biological variation between these clinical entities. The role of oxidative processes underlying bipolar disorder and depression has been demonstrated. Thiol-disulfide homeostasis (TDH) is a recent oxidative stress marker. In this study, we aimed to inspect patients with bipolar depression and unipolar depression in terms of thiol-disulfide balance and to compare them with healthy controls. Methods: Patients admitted to the outpatient clinic of Ankara Numune Training and Research Hospital and diagnosed either as a depressive episode with bipolar disorder (n = 37) or unipolar depression (n = 24) according to DSM-5 criteria, along with healthy controls (HC) (n = 50), were included in the study. Native thiol, total thiol, and disulfide levels were compared across the groups. Results: In comparison to HC, both BD and UD groups had higher disulfide levels, disulfide/native thiol ratio, and disulfide/total thiol ratio. No significant differences between BD and UD were detected in terms of disulfide level, disulfide/native thiol ratio, and disulfide/total thiol ratio. Conclusion: Increased levels of disulfide, native thiol, and disulfide/total thiol ratios compared to healthy controls in both UD and BD groups may be indicative of the presence of oxidative damage in these two clinical conditions. To clarify the role of oxidative stress in the pathophysiology of depressive disorders and investigate TDH, longitudinal studies in patients with medication-free UD and BD are required.

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