Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Baykan, Ahmed Ramiz; Bıçer, Cemile; Gerçeker, Emre; Erel, Özcan; Cerrah, Serkan; Albayrak, Bülent; Utlu, Mustafa; Kargılı, Ayşe

doi:10.18621/eurj.443557

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…Naja et al has found no significant difference in the plasma thiol level in HP infected patients compared with controls [23]. Baykan et al reported that there was no difference between the total thiol, native thiol, disulphide/native thiol and dissulphide/total thiol ratios of the HP (+) patients and control group [24]. They claimed severity of inflammation affected their results.…”

Section: Discussionmentioning

confidence: 96%

Helicobacter pylori ve tiyol-disülfid homeostazı arasındaki ilişki: Prospektif, gözlemsel bir çalışma

Erdoğdu

Çaycı

Tardu

et al. 2020

Archives of Clinical and Experimental Medicine

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Aim: Helicobacter pylori (HP) infection causes inflammation and oxidative stress at a cellular level. In the present study, we aimed to evaluate the possible relationship between HP and thiol-disulfide homeostasis (TDH), a novel indicator of oxidative stress. Methods: Medical data of a total of 53 patients admitted with persistent dyspepsia and undergoing gastroscopy were evaluated prospectively. The patients were divided into two groups, based on the result of gastric biopsy, as HP-positive (+) and HP-negative (-). Demographic data, ferric-reducing ability of plasma (FRAP), ischemiamodified albumin (IMA), native thiol, total thiol, disulfide, and malondialdehyde (MDA) levels of the patients were recorded and compared between the two groups. Results: The native thiol (451.03 mmol/L vs. 407.03mmol/L, p=0.005) and total thiol (493.20 mmol/L vs. 456.40 mmol/L, p=0.027) levels were significantly higher in the HP (+) group than in the HP (-) group. The disulfide levels and disulfide/native thiol, disulfide/total thiol and native thiol/total thiol ratios were similar between the HP (+) and HP (-) groups. Although the FRAP was lower in the HP (+) group than in the HP (-) group, this difference was not statistically significant (0.94 mmol/L vs. 1.10 mmol/L). No statistically significant difference was found between the groups in the IMA and MDA levels.. Conclusion: In this study, oxidative status of HP patients was evaluated in several different methods. Among them, only elevated native thiol and total thiol levels were found in HP-induced gastritis. There is a need for further studies involving a larger number of patients and a subgroup analysis to examine whether elevated serum thiol-disulfide levels in HP infection suggest an antioxidant or pro-oxidant status.

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Section: Discussionmentioning

confidence: 96%

Helicobacter pylori ve tiyol-disülfid homeostazı arasındaki ilişki: Prospektif, gözlemsel bir çalışma

Erdoğdu

Çaycı

Tardu

et al. 2020

Archives of Clinical and Experimental Medicine

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“…A previous study involving patients with H. pylori infection showed a correlation between the severity of endoscopically detected gastritis and the plasma disulfide level. [ 27 ]…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia

Ebik¹,

Aslan²,

Ekin³

et al. 2022

Saudi Journal of Gastroenterology

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Background: To investigage the thiol and disulphide levels in Helicobacter pylori -positive patients with non-ulcer dyspepsia and investigate the change in these levels with eradication therapy. Methods: This is a prospective observational study. A total of 320 patients diagnosed with dyspepsia according to Rome IV criteria were included in the study. First, blood samples were drawn from patients to determine their serum thiol and disulphide levels. Endoscopic biopsy was performed on all patients and the biopsy specimens obtained were examined pathologically. Patients positive for H. pylori were administered eradication therapy. Blood samples were drawn from these patients for the second time, and their serum thiol and disulphide levels were measured. The thiol–disulfide levels of the patients who were successful in H. pylori eradication treatment, with those who were not, were compared before and after the treatment. Results: The mean plasma disulphide level decreased significantly from 14.0 ± 6.6 to 10.9 ± 5.9 μmol/L in H. pylori -positive patients that responded to the H. pylori eradication treatment ( P = 0.033). On the other hand, there was an insignificant increase in the mean serum thiol level (341.4 ± 30.5 vs. 342.6 ± 29.8 μmol/L; P = 0.273) and an insignificant decrease in the mean serum disulphide level (15.2 ± 2.5 vs. 14.8 ± 2.3 μmol/L; P = 0.163) in H. pylori -positive patients that did not respond to the H. pylori eradication treatment. Conclusion: The inflammation caused by H. pylori shifted the thiol–disulphide equilibrium in the cell redox system towards the direction of disulphide. The study findings suggest that the restoration of the said hemostatic balance with eradication therapy relieved the organism from oxidative stress.

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Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Cited by 2 publications

References 37 publications

Helicobacter pylori ve tiyol-disülfid homeostazı arasındaki ilişki: Prospektif, gözlemsel bir çalışma

Helicobacter pylori ve tiyol-disülfid homeostazı arasındaki ilişki: Prospektif, gözlemsel bir çalışma

Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia

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