2020
DOI: 10.1080/10667857.2020.1800307
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Thiolated and carboxymethylated Cassia obtusifolia seed mucilage as novel excipient for drug delivery: development and characterisation

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Cited by 8 publications
(3 citation statements)
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“…Asymmetrical vibrations were also detected between 1075 and 1045 cm −1 , whose are assigned to C–O–C stretching of glycosidic bonds and C–O–H bending [28] . In parallel, the FT-IR spectra of cassia tora gum showed an absorption peak at 1654 cm −1 indicating the presence of carbonyl groups [40] , while stretching vibrations at 1022 cm −1 are attributed to C–H bending, indicating carbohydrate fractions in the mucilage [41] .…”
Section: Resultsmentioning
confidence: 92%
“…Asymmetrical vibrations were also detected between 1075 and 1045 cm −1 , whose are assigned to C–O–C stretching of glycosidic bonds and C–O–H bending [28] . In parallel, the FT-IR spectra of cassia tora gum showed an absorption peak at 1654 cm −1 indicating the presence of carbonyl groups [40] , while stretching vibrations at 1022 cm −1 are attributed to C–H bending, indicating carbohydrate fractions in the mucilage [41] .…”
Section: Resultsmentioning
confidence: 92%
“…Mucoadhesive formulations are usually administered to oral [ 18 ], vaginal [ 19 ] and nasal [ 20 , 21 ] mucosa but there are also examples of particulate formulations [ 22 ] or tablets [ 23 ] administered orally and adhering to gastric mucosa. However, in the case of formulations aiming at the mucoadhesive effect, usually chemically modified gums with thiol groups introduced to the structure are obtained and investigated [ 24 , 25 , 26 , 27 ]. Thiol groups can interact with cysteine occurring in mucin, which results in covalent bond formation and strong attachment to the surface of mucous membrane.…”
Section: Natural Gumsmentioning
confidence: 99%
“…Phytochemical investigation. The mucilage extracts were subjected to phytochemical qualitative reactions for usual plant secondary metabolites as described by the method reported by Deore 73 . The extract was tested with specific reagents for the presence of starch, alkaloids, saponins, tannins, steroids, and glycosides.…”
Section: Ecolimentioning
confidence: 99%