Thiolation of Maghemite Nanoparticles by Dimercaptosuccinic Acid

Fauconnier, N.; Pons, Jean-Noël; Roger, Jacky; Bée, Agnès

doi:10.1006/jcis.1997.5125

Cited by 233 publications

(179 citation statements)

References 13 publications

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“…The latter is of great importance in so far as reducing the fast blood clearance of nanoparticles after injecting them into the body. For the purpose of making easier the effective binding of polymers on the surface of the magnetic nanoparticles various molecules (like alkoxysilanes, dimercaptosuccinic acid (DMSA)) can be utilized (Fauconnier et al, 1997).…”

Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

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Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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“…electrostatic or covalent bonding), the conformation of the polymer, and the degree of particle surface coverage. Various monomeric species, such as bisphosphonates [62], dimercaptosuccinic acid (DMSA) [63] and alkoxysilanes [64,65], have been evaluated as anchors to facilitate attachment of polymer coatings on MNPs. The molecular weight and geometric orientation of the polymer on the surface of the particles in the form of loops, trains, and tails [66] or as end-grafted brushes (Fig.…”

Section: Polymeric Coatingsmentioning

confidence: 99%

Magnetic nanoparticles in MR imaging and drug delivery

Sun

Lee

Zhang

2008

Advanced Drug Delivery Reviews

2,344

1,507

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Magnetic nanoparticles (MNPs) possess unique magnetic properties and the ability to function at the cellular and molecular level of biological interactions making them an attractive platform as contrast agents for magnetic resonance imaging (MRI) and as carriers for drug delivery. Recent advances in nanotechnology have improved the ability to specifically tailor the features and properties of MNPs for these biomedical applications. To better address specific clinical needs, MNPs with higher magnetic moments, non-fouling surfaces, and increased functionalities are now being developed for applications in the detection, diagnosis, and treatment of malignant tumors, cardiovascular disease, and neurological disease. Through the incorporation of highly specific targeting agents and other functional ligands, such as fluorophores and permeation enhancers, the applicability and efficacy of these MNPs have greatly increased. This review provides a background on applications of MNPs as MR imaging contrast agents and as carriers for drug delivery and an overview of the recent developments in this area of research.

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“…Iron oxide nanoparticles with (di)mercaptosuccinic acid have been shown to exhibit both carboxylic and thiol functional groups (Fauconnier et al 1997;Wilhelm et al 2003).…”

Section: Particle Functionalization (A) Chemical Functional Groupsmentioning

confidence: 99%

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Sperling

Parak

2010

Phil. Trans. R. Soc. A.

1,409

1,092

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Inorganic colloidal nanoparticles are very small, nanoscale objects with inorganic cores that are dispersed in a solvent. Depending on the material they consist of, nanoparticles can possess a number of different properties such as high electron density and strong optical absorption (e.g. metal particles, in particular Au), photoluminescence in the form of fluorescence (semiconductor quantum dots, e.g. CdSe or CdTe) or phosphorescence (doped oxide materials, e.g. Y 2 O 3 ), or magnetic moment (e.g. iron oxide or cobalt nanoparticles). Prerequisite for every possible application is the proper surface functionalization of such nanoparticles, which determines their interaction with the environment. These interactions ultimately affect the colloidal stability of the particles, and may yield to a controlled assembly or to the delivery of nanoparticles to a target, e.g. by appropriate functional molecules on the particle surface. This work aims to review different strategies of surface modification and functionalization of inorganic colloidal nanoparticles with a special focus on the material systems gold and semiconductor nanoparticles, such as CdSe/ZnS. However, the discussed strategies are often of general nature and apply in the same way to nanoparticles of other materials.

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Thiolation of Maghemite Nanoparticles by Dimercaptosuccinic Acid

Cited by 233 publications

References 13 publications

Maghemite Functionalization for Antitumor Drug Vehiculization

Maghemite Functionalization for Antitumor Drug Vehiculization

Magnetic nanoparticles in MR imaging and drug delivery

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

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