Thiophenes and their Benzo Derivatives: Applications

Recent Advances in Microwave-Assisted Synthesis of Heterocyclic Compounds

“…Five-membered sulfur containing heterocycles are important synthetic intermediates and have found a variety of applications in medicinal, agricultural, and materials chemistry [207][208][209]. In particular, substituted thiophenes have found industrial applications as dyes and conducting polymers [210,211].…”

Diverse Methyl Sulfone-Containing Benzo[b]thiophene Library via Iodocyclization and Palladium-Catalyzed Coupling

“…Benzo[ b ]thiophenes are of interest because of their frequent occurrence in nature and their wide range of biological and physiological effects. − Benzo[ b ]thiophene derivatives currently in pharmaceutical use or development include selective estrogen receptor modulators (SERMs), − tubulin-binding agents, ,, modulators of multidrug resistance, and anti-inflammatory agents to name but a few.…”

Catalytic synthesis of methanethiol from CO/H2/H2S mixtures using α-Al2O3

“…In contrast, there has been very limited investigation of the reactions of synthesis gas in the presence of other reactants, in particular sulfur-containing molecules such as H 2 S. This is surprising since the reaction of CO:H 2 :H 2 S mixtures could be expected to lead to the formation of methanethiol and thiophene, both of which are useful intermediates in the synthesis of pharmaceuticals, agrochemicals and polymers. [3][4][5] In the reactions of CO/H 2 mixtures in the Fischer-Tropsch synthesis it should be noted that aromatic compounds are not favoured. 2 However, thiophene readily forms from the reactions of alcohols and aldehydes with sulfided surfaces [6][7][8][9][10] and as alcohols/aldehydes can be formed during the Fischer-Tropsch synthesis, 2 it is anticipated that thiophene could be a viable synthesis target.…”