Thioproline prevents carcinogenesis in the remnant stomach induced by duodenal reflux

Suo, Masashi; Mukaisho, Ken‐ichi; Shimomura, Akihiko; Sugihara, Hiroyuki; Hattori, Takanori

doi:10.1016/j.canlet.2005.06.019

Cited by 25 publications

(28 citation statements)

References 28 publications

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“…It was found in cooked seeds of P. speciosa but was undetectable in uncooked seeds [21]. The compound is an effective nitrite-trapping agent which can inhibit the endogenous formation of carcinogenic N-nitroso compounds [60]. Its derivatives were previously designed and synthesized as novel influenza neuraminidase inhibitors [61].…”

Section: Properties Of P Speciosamentioning

confidence: 99%

Parkia speciosaHassk.: A Potential Phytomedicine

Kamisah

Othman

Qodriyah

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Parkia speciosa Hassk., or stink bean, is a plant indigenous to Southeast Asia. It is consumed either raw or cooked. It has been used in folk medicine to treat diabetes, hypertension, and kidney problems. It contains minerals and vitamins. It displays many beneficial properties. Its extracts from the empty pods and seeds have a high content of total polyphenol, phytosterol, and flavonoids. It demonstrates a good antioxidant activity. Its hypoglycemic effect is reported to be attributable to the presence of β-sitosterol, stigmasterol, and stigmast-4-en-3-one. The cyclic polysulfide compounds exhibit antibacterial activity, while thiazolidine-4-carboxylic acid possesses anticancer property. The pharmacological properties of the plant extract are described in this review. With ongoing research conducted on the plant extracts, Parkia speciosa has a potential to be developed as a phytomedicine.

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Section: Properties Of P Speciosamentioning

confidence: 99%

Parkia speciosaHassk.: A Potential Phytomedicine

Kamisah

Othman

Qodriyah

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Except for in the area of the anastomosis, no pathology nor peritoneal metastases were seen. According to classification used in similar reflux models, the changes were categorized as follows [28]:…”

Section: Histopathological Analysismentioning

confidence: 99%

Bioactive Fatty Acids Reduce Development of Gastric Cancer Following Duodenogastric Reflux in Rats

Christensen¹,

Berge²,

Wergedahl³

et al. 2012

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Background: Bioactive fatty acids such as the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the modified fatty acid analogue, tetradecylthioacetic acid (TTA), are known to influence inflammatory processes in the body. Our aim was to investigate if diets containing fish oil (FO) enriched with bioactive fatty acids could affect inflammation and development of glandular stomach carcinogenesis in a duodenogastric reflux (DGR) animal model. We also wanted to evaluate if a high-fat diet might increase the risk of developing gastric cancer compared to a low-fat diet. Methods: 185 rats operated on with a gastroenterostomy were randomly allocated to 5 different treatment groups given: low-fat, high-fat, high-fat + FO, high-fat + TTA or high-fat + FO + TTA. The stomachs were removed after 50 weeks and examined by light microscopy with hematoxylin and eosin staining (HE). Immunohistochemical staining against COX-2, PCNA and p53 was performed when adenocarcinomas were found. The plasma fatty acid profile was determined. Results: Adenocarcinomas developed in 21% of animals fed the low-fat diet, 35% in the high-fat group, 16% in the high-fat + TTA group, 21% in the high-fat + FO group and 8.6% in the high-fat + FO + TTA treatment group. COX-2 and PCNA were positive whereas p53 was negative in the majority of the samples. The anti-inflammatory fatty acid index increased after treatment with FO and in combination with FO and TTA. Conclusion: FO and TTA in combination with a high-fat diet significantly lower the risk of developing adenocarcinomas in rats subjected to duodenogastric reflux. This is most likely due to a selective modulation of inflammation.

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“…Molecules were designed in accordance to previous studies, in which it has been demonstrated that bulky alkyl groups other than OH at 5 0 -position of adenosine have a loss in affinity for ADA (Ciuffreda et al, 2003). In addition to the theoretical reduction of metabolism by steric hindrance, the use of progroups with antioxidant or hepatoprotective activities, such as glycine (Senthilkumar et al, 2003;Ligumsky et al, 1995), alanine (Ishizaki et al, Ishizaki-Koizumi et al 2002), thioproline (Gulizar, 2004;Suo et al, 2006), and its non-sulfured analog proline, could offer further benefits in the protection of hepatic injury during fibrosis and cirrhosis, without significant loss in aqueous solubility.…”

Section: Introductionmentioning

confidence: 99%

Potential utility of adenosine 5′-ester prodrugs to enhance its plasma half-life: synthesis and molecular docking studies

Hernández‐Vázquez

Chagoya

2014

Med Chem Res

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Adenosine, the adenine nucleoside, has demonstrated various pharmacological properties related to the treatment of relevant clinical diseases. With respect to this, one of the most fascinating biological activities of adenosine is its capacity for reversing hepatic fibrosis, which has been established in several in vitro and in vivo studies. Although adenosine seems to be a privileged compound, it lacks of metabolic stability to be considered as a drug candidate. For this reason, in this preliminary study, six prodrugs were developed in order to enhance the plasma half-life of adenosine, in which the esterification at 5 0 position of adenosine was considered. According to previous works, the increase in steric hindrance at this position could develop unfavorable interactions inside adenosine deaminase (ADA) catalytic domain, which is reported as the main enzyme implicated in adenosine metabolism. Besides, molecular docking was employed to verify if the hindrance at carbinol group in the prodrugs is enough to diminish its oxidation and also to predict if compounds would be metabolized by a promiscuous esterase. Finally, the in vitro assays corroborated the theoretical findings and also indicated that the compounds are less metabolized than adenosine by ADA; in the case of compounds containing proline and thioproline progroups (4d and 4e, respectively), the reduction was more than three-fold of decrease.

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Thioproline prevents carcinogenesis in the remnant stomach induced by duodenal reflux

Cited by 25 publications

References 28 publications

Parkia speciosaHassk.: A Potential Phytomedicine

Parkia speciosaHassk.: A Potential Phytomedicine

Bioactive Fatty Acids Reduce Development of Gastric Cancer Following Duodenogastric Reflux in Rats

Potential utility of adenosine 5′-ester prodrugs to enhance its plasma half-life: synthesis and molecular docking studies

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