2004
DOI: 10.1038/sj.onc.1207334
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Thioredoxin, a regulator of gene expression

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Cited by 17 publications
(10 citation statements)
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“…Thioredoxin-1 (Trx-1) is a proto-oncogene that stimulates tumor growth and inhibits both spontaneous and drug induced apoptosis [1][2][3]. Plasma Trx-1 protein levels, are significantly elevated in several human cancer types including gastric, colorectal, pancreatic, lung and breast cancer, and increased levels appear to correlate with shorter survival [4,5].…”
Section: Introductionmentioning
confidence: 99%
“…Thioredoxin-1 (Trx-1) is a proto-oncogene that stimulates tumor growth and inhibits both spontaneous and drug induced apoptosis [1][2][3]. Plasma Trx-1 protein levels, are significantly elevated in several human cancer types including gastric, colorectal, pancreatic, lung and breast cancer, and increased levels appear to correlate with shorter survival [4,5].…”
Section: Introductionmentioning
confidence: 99%
“…The fact that cancer cells have high levels of thioredoxin and that reduced cellular thioredoxin levels can cause cancer-prone disease (reviewed in Kontou et al 2004) emphasizes the importance of this protein in humans. In plants, the thioredoxin system is particularly complex because at least 20 thioredoxin isoforms have been found (reviewed in, e.g., Gelhaye et al 2005).…”
Section: Introductionmentioning
confidence: 99%
“…Thioredoxins are not only involved in this type of peroxidase cascade, but are also implicated in numerous biological events where regulation of protein function and signalling processes can be achieved by thiol redox control (Arner & Holmgren, 2000;Buchanan & Balmer, 2005;Raina & Missiakas, 1997). These include regulation of transcription (Kontou et al, 2004) and a molecular-chaperone function (Kern et al, 2003;Raina & Missiakas, 1997).…”
Section: Introductionmentioning
confidence: 99%