Thioridazine-Induced Inhibition of Masturbatory Ejaculation in an Adolescent

Greenberg, Harvey Roy; Carrillo, Carlos

doi:10.1176/ajp.124.7.991

Cited by 16 publications

(3 citation statements)

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“…It has been known for a long time that men treated with thioridazine, an antipsychotic drug, or phenoxybenzamine, an anti- hypertensive agent, become infertile due to failure of ejaculation, even though orgasm is normal (92,93). It was suggested that this contraceptive effect of phenoxybenzamine was due to a selective blockade of α-adrenoreceptors in longitudinal but not in circular muscular contractions of the vas deferens (94), a concept that is supported by in vitro observations (95).…”

Section: New Leads For Contraceptivesmentioning

confidence: 98%

As the world grows: contraception in the 21st century

Aitken¹,

Baker²,

Doncel³

et al. 2008

J. Clin. Invest.

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Contraceptives that are readily available and acceptable are required in many poorer countries to reduce population growth and in all countries to prevent maternal morbidity and mortality arising from unintended pregnancies. Most available methods use hormonal steroids or are variations of barrier methods. Reports from several fora over the last 12 years have emphasized the number of unwanted pregnancies and resultant abortions, which indicate an unmet need for safe, acceptable, and inexpensive contraceptive methods. This unmet need can be assuaged, in part, by development of new nonhormonal contraceptive methods. This Review addresses the contribution that the "omic" revolution can make to the identification of novel contraceptive targets, as well as the progress that has been made for different target molecules under development.

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Section: New Leads For Contraceptivesmentioning

confidence: 98%

As the world grows: contraception in the 21st century

Aitken¹,

Baker²,

Doncel³

et al. 2008

J. Clin. Invest.

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“…Another drug affecting vas deferens muscles contraction is thioridazine -an antipsychotic phenothiazine derivative [26].…”

Section: Drugs Suppressing Muscle Contraction Of Vas Deferensmentioning

confidence: 99%

Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception

Zdrojewicz¹,

Konieczny²,

Papier³

et al. 2015

Adv Clin Exp Med

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Compared to efficient and secure female contraception, a vasectomy and condoms are the only options for men. The choice of male contraceptive methods is limited, so contraception mainly rests on the shoulders of women. Several concepts are considered: testosterone administration -inhibiting pituitary secretion of lutropin (LH) and follicle stimulating hormone (FSH), progestogen -affecting the secretion of gonadotropin and gonadoliberin (GnRH) antagonists. New potential targets for non-hormonal male contraception were discovered: glyceraldehyde-3-phosphate-dehydrogenase (GAPDHS) -specific to male germ cells and voltage-gated cation channel (CatSper). Both are responsible for sperm motility. Drugs such as thioridazine used in schizophrenia treatment and phenoxybenzamine (antihypertensive activity) exhibit a contraceptive effect. Similar action exhibits an analogue of lonidamine -adjudin and an antagonist of retinoic acid receptors (BMS-189453). Researchers are working on a contraceptive vaccine, whose active ingredient is epididymal protease inhibitor (Eppin). Another promising method acts by blocking Bromodomain testis-specific proteins (Brdt) involved in the process of spermatogenesis. JQ1-the Brdt inhibitor causes reversible infertility without affecting the endocrine signaling pathways. A recent discovery of Juno as the binding partner for Izumo1 identifies these proteins as the cell-surface receptor pair, essential for gamete recognition and this interaction can be inhibited by an anti-Juno monoclonal antibody. Our review shows that the situation of men can change and investigators are close to the optimal solution. In the near future men will be able to choose the best contraceptive suited to their needs (Adv Clin Exp Med 2015, 24, 4, 705-714).

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“…Thioridazine inhibits sperm emission in patients without affecting normal erection or the sensation of orgasm (Greenberg & Carrillo, 1968;Kotin et ai, 1976). This effect has been used to inhibit nocturnal emissions and control premature ejaculation (Clein, 1962;Singh, 1963).…”

Section: Introductionmentioning

confidence: 99%

Effects of thioridazine on mechanical responses of human vas deferens induced by noradrenaline or potassium

Amobi

Smith²

1992

Reproduction

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Summary. Thioridazine (0\ m=. \ 1\ p=n-\ 10\g=m\moll \ m=-\ 1) inhibited shortening of specimens of human vasa deferentia induced by noradrenaline (100 \g=m\moll \ m=-\ 1 ) or high extracellular potassium (136 mmol l \ m=-\ 1). Thioridazine did not inhibit the lengthening response. In Ca2+ -free media with EGTA (0\m=.\5 mmol l \m=-\ 1) similar results were obtained with responses to noradrenaline, but exposure to potassium elicited small contractions that were potentiated by thioridazine. Both shortening and lengthening responses to noradrenaline were antagonized by the \g=a\-adrenoceptor blockers prazosin (1\p=n-\10\g=m\mol l \ m=-\ 1) and phentolamine (1\p=n-\10 \g=m\moll\m=-\1) and by the Ca2+ antagonists verapamil (10 \g=m\moll \ m=-\ 1) and diltiazem (10 \g=m\mol l \ m=-\ 1). Responses to potassium were virtually abolished by the Ca2+ antagonists.These results show that thioridazine specifically inhibits longitudinal muscle of the human vas deferens and that its action cannot be entirely accounted for by a blockade of voltage-gated Ca2+ channels.

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Thioridazine-Induced Inhibition of Masturbatory Ejaculation in an Adolescent

Cited by 16 publications

References 0 publications

As the world grows: contraception in the 21st century

As the world grows: contraception in the 21st century

Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception

Effects of thioridazine on mechanical responses of human vas deferens induced by noradrenaline or potassium

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