2020
DOI: 10.1039/d0dt01309a
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Thiosemicarbazone(s)-anchored water soluble mono- and bimetallic Cu(ii) complexes: enzyme-like activities, biomolecular interactions, anticancer property and real-time live cytotoxicity

Abstract: The synthesized Cu(ii) complexes, especially bimetallic complexes, exhibited versatile anticancer and enzyme-like activities.

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Cited by 61 publications
(32 citation statements)
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“…Metals combined with organic motifs are becoming increasingly dominant with their vast number of applications [7–10] . In the pharmaceutical industry, although many drugs in the market are seemingly organic in nature, organometallic compounds offer various benefits over their organic counterparts.…”
Section: Introductionmentioning
confidence: 99%
“…Metals combined with organic motifs are becoming increasingly dominant with their vast number of applications [7–10] . In the pharmaceutical industry, although many drugs in the market are seemingly organic in nature, organometallic compounds offer various benefits over their organic counterparts.…”
Section: Introductionmentioning
confidence: 99%
“…N5 intramolecular hydrogen bond that stabilizes the conformation of the molecules observed in the crystal. The methoxy groups in T3 are located almost coplanar with the plane of the benzene ring and they have a trans conformation with respect to C23-C24 bond confirmed by the torsion angles C24-C23-O27-C28 and C23-C24-O28-C29 of −172.08 (14) and −174.28 (12) • , respectively. In all investigated molecules the benzene rings are planar within 0.005(4) Å in T2, 0.0121 (14) Å in T3 and 0.010(3) Å in T5 and the planes of these rings are inclined with respect to the mean planes of thiosemicarbazone functions at an angle of 9.65(11), 8.08(4) and 4.03 7• for T2, T3, and T5, respectively, which shows that all molecules as a whole are almost flat.…”
Section: Chemistrymentioning
confidence: 96%
“…A view of these molecules in conformation observed in the crystal is shown in Figure 1. The C2=S3, N4-N5, and N5=C6 bond lengths of 1.686(4), 1.373 (4), and 1.266(5) Å in T2, 1.6896(13), 1.3809 (14), and 1.2766 (17) Å in T3 and 1.693(3), 1.375 (3), and 1.272(3) Å in T5, respectively, are characteristic for those observed in other organic molecules containing thiosemicarbazone system [22,23] and confirming that the thione tautomeric form is observed in the crystalline state. In all analyzed molecules the thiosemicarbazone skeleton N1/C2/S3/N4/N5/C6 is slightly distorted from planarity with the largest deviation from the mean plane of 0.025(3) Å for N5 in T2, 0.0563 (12) Å for N4 in T3 and 0.015(2) Å for N4 in T5.…”
Section: Chemistrymentioning
confidence: 99%
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