Thiotepa 10 mg/kg Treatment Regimen Is Superior to Thiotepa 5 mg/kg in TBF Conditioning in Patients Undergoing Allogeneic Stem-Cell Transplantation

Effect of the Thiotepa Dose in the TBF Conditioning Regimen in Patients Undergoing Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in Complete Remission: A Report From the EBMT Acute Leukemia Working Party

“…12 Recently, we published a study proving the superiority of thiotepa at 10mg/kg in the TBF conditioning regimen for patients undergoing allo-SCT for hematologic malignancies compared to thiotepa at 5 mg/kg. 7 Engraftment was observed in all cases, suggesting a sufficient immunosuppressive activity of both doses of thiotepa with fludarabine in combination with intermediate doses of busulfan and anti-thymocyte globulin (ATG). The incidence of acute GVHD was comparable between the two groups of patients receiving thiotepa at 5mg/kg and at 10mg/kg.…”

“…5,6 However, few studies have focused on analyzing the effect of the thiotepa dose in TBF conditioning. 7 In an attempt to assess the optimal dose of thiotepa, we retrospectively compared the effect of the dose intensity of thiotepa on the outcome of a homogeneous population. We chose to study patients undergoing allo-SCT for AML after achieving complete remission (CR).…”