Thiourea as oxyanion stabilizer for Iridium catalyzed, base free green synthesis of amines: Synthesis of cardiovascular drug ticlopidine

Kumar, Kankanala Naveen; Reddy, Malladi Mounika; Panchami, Hirave; Ravichandiran, V.; Dhaked, Devendra K.; Swain, Sharada Prasanna

doi:10.1016/j.mcat.2022.112324

Cited by 6 publications

(3 citation statements)

References 74 publications

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“…2.6. Thiourea as oxyanion stabilizer for amination of alcohols: Synthesis of cardiovascular drug ticlopidine 22 Schreiner's thiourea can as an oxyanion stabilizer and facilitate [Ir] catalyzed amination of alcohols 51 without any base or strong acid (Scheme 10). Our laboratory has developed [Cp*IrCl2]2 and thiourea catalyzed amination of alcohol in 60-82% yield.…”

Section: Enantioselective Michael Addition Of 13-dicarbonyl Compounds...mentioning

confidence: 99%

Thiourea catalysts for synthesis of Active Pharmaceutical Ingredients

Swain

Kumar²,

Ravichandiran³

2023

Preprint

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Thiourea is an important building block found in several drug molecules such as thioacetazone, enzalutamide, thiocarlide etc. Thiourea derivatives have been used for activation of carbonyl and imine compounds to facilitate Michael addition reactions, and as an oxyanion stabilizer for [Ir] catalyzed amination of alcohols without using any base or acid. Chiral bifunctional thiourea catalysts have been successfully applied for asymmetric synthesis of several drug molecules.

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Section: Enantioselective Michael Addition Of 13-dicarbonyl Compounds...mentioning

confidence: 99%

Thiourea catalysts for synthesis of Active Pharmaceutical Ingredients

Swain

Kumar²,

Ravichandiran³

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…15–19 Our lab is focussing on the development of green synthetic methods and their applications for the preparation of active pharmaceutical ingredients (APIs). 20,21…”

Section: Introductionmentioning

confidence: 99%

“…29 We attempted to study the α-amination of esters using a CuBr 2 catalyst, as part of our lab's current ongoing research on the development of Cu-catalysed synthetic methods and synthesis of APIs. 20,21 Herein, we report α-amination of esters under continuous-flow conditions with reduced CuBr 2 catalyst loading (0.05%) in the presence of NMO as a pharmaceutically acceptable oxidant. 26,30…”

Section: Introductionmentioning

confidence: 99%