Thirst interneurons that promote water seeking and limit feeding behavior in Drosophila

Landayan, Dan; Wang, Brian P; Zhou, Jennifer; Wolf, Fred W.

doi:10.7554/elife.66286

Cited by 28 publications

(40 citation statements)

References 53 publications

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“…Prior work has implicated specific neuronal pathways in regulating levels of water consumption and in the thirst-dependent control of innate and learned water-seeking (Jourjine et al, 2016; Lin et al, 2014; Landayan et al, 2021; Senapati et al, 2019). Given that astrocytes broadly innervate the neuropil we reasoned that D-serine might provide a more general signal promoting water procuring behaviors.…”

Section: Resultsmentioning

confidence: 99%

“…Further work will be required to locate the critical D-serine modulated connections and circuits in the fly brain. We assume different circuits will underlie D-serine regulated learned water seeking and consumption (Hsu et al, 2020; Jourjine et al, 2016; Landayan et al, 2021; Lin et al, 2014b; Senapati et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Although in lab conditions Drosophila are raised on food that contains water, they can selectively seek either food or water when necessary, and prior work has established that they possess independent control mechanisms for food and water seeking (Hsu et al, 2020; Krashes et al, 2009; Landayan et al, 2021; Lin et al, 2014; Senapati et al, 2019). Thirst and hunger are however also coupled on a behavioral and neuronal level.…”

Section: Discussionmentioning

confidence: 99%

“…CC-BY-NC-ND 4.0 International license made available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is Prior work has implicated specific neuronal pathways in regulating levels of water consumption and in the thirst-dependent control of innate and learned water-seeking (Jourjine et al, 2016;Lin et al, 2014;Landayan et al, 2021;Senapati et al, 2019). Given that astrocytes broadly innervate the neuropil we reasoned that D-serine might provide a more general signal promoting water procuring behaviors.…”

Section: D-serine Promotes Water-memory Expressionmentioning

confidence: 98%

“…Interestingly, ISN activation (via Adipokinetic Hormine, AKH) suppresses drinking and instead promotes feeding. Two other classes of SEZ neurons, the Janu neurons, regulate water seeking behavior up a humidity gradient, but not total water consumption (Landayan et al, 2021). The Janu neurons are either GABAergic or Allatostatin (AstA)-releasing.…”

Section: Introductionmentioning

confidence: 99%

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Gliotransmission of D-serine promotes thirst-directed behaviors inDrosophila

Park

Croset

Otto

et al. 2022

Preprint

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Thirst emerges from a range of cellular changes that ultimately motivate an animal to consume water. Although thirst-responsive neuronal signals have been reported, the full complement of brain responses is unclear. Here we identify molecular and cellular adaptations in the brain using single-cell sequencing of water deprived Drosophila. Water deficiency primarily altered the glial transcriptome. Screening the regulated genes revealed astrocytic expression of the astray-encoded phosphoserine phosphatase to bi-directionally regulate water consumption. Astray synthesizes the gliotransmitter D-serine and vesicular release from astrocytes is required for drinking. Moreover, dietary D-serine rescues aay-dependent drinking deficits while facilitating water consumption and expression of water-seeking memory. D-serine action requires binding to neuronal NMDA-type glutamate receptors. Fly astrocytes contribute processes to tripartite synapses and the proportion of astrocytes that are themselves activated by glutamate increases with water deprivation. We propose that thirst elevates astrocytic D-serine release, which awakens quiescent glutamatergic circuits to enhance water procurement.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: D-serine Promotes Water-memory Expressionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Gliotransmission of D-serine promotes thirst-directed behaviors inDrosophila

Park

Croset

Otto

et al. 2022

Preprint

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Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models

Mou,

Zhang,

Zheng

et al. 2024

Advanced Science

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While animals across species typically experience suppressed consciousness and an increased arousal threshold during sleep, the responsiveness to specific sensory inputs persists. Previous studies have demonstrated that rhythmic and continuous vibration can enhance sleep in both animals and humans. However, the neural circuits underlying vibration‐induced sleep (VIS) and its potential therapeutic benefits on neuropathological processes in disease models remain unclear. Here, it is shown that intermittent vibration, such as cycles of 30 s on followed by 30 s off, is more effective in inducing sleep compared to continuous vibration. A clear evidence is further provided that allatostatin A (AstA)‐GABA signaling mediates short‐term intermittent vibration‐induced sleep (iVIS) by inhibiting octopaminergic arousal neurons through activating GABAA receptors. The existence of iVIS in mice is corroborated, implicating the GABAergic system in this process. Finally, intermittent vibration not only enhances sleep but also reduces amyloid‐β (Aβ) deposition and reverses memory defects in Alzheimer's disease models. In conclusion, the study defines a central neural circuit involved in mediating short‐term iVIS and the potential implications of vibration in treating sleep‐related brain disorders.

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Managing fuels and fluids: Network integration of osmoregulatory and metabolic hormonal circuits in the polymodal control of homeostasis in insects

Koyama,

Rana,

Halberg

2023

BioEssays

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Osmoregulation in insects is an essential process whereby changes in hemolymph osmotic pressure induce the release of diuretic or antidiuretic hormones to recruit individual osmoregulatory responses in a manner that optimizes overall homeostasis. However, the mechanisms by which different osmoregulatory circuits interact with other homeostatic networks to implement the correct homeostatic program remain largely unexplored. Surprisingly, recent advances in insect genetics have revealed several important metabolic functions are regulated by classic osmoregulatory pathways, suggesting that internal cues related to osmotic and metabolic perturbations are integrated by the same hormonal networks. Here, we review our current knowledge on the network mechanisms that underpin systemic osmoregulation and discuss the remarkable parallels between the hormonal networks that regulate body fluid balance and those involved in energy homeostasis to provide a framework for understanding the polymodal optimization of homeostasis in insects.

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Thirst interneurons that promote water seeking and limit feeding behavior in Drosophila

Cited by 28 publications

References 53 publications

Gliotransmission of D-serine promotes thirst-directed behaviors inDrosophila

Gliotransmission of D-serine promotes thirst-directed behaviors inDrosophila

Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models

Managing fuels and fluids: Network integration of osmoregulatory and metabolic hormonal circuits in the polymodal control of homeostasis in insects

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